The role of selenium in cardiology

Kuropatkina, T.; Medvedeva, N. A.; Медведев, О. С.

doi:10.18087/cardio.2021.3.n1186

Kardiologiia

2021

DOI: 10.18087/cardio.2021.3.n1186

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The role of selenium in cardiology

T. Kuropatkina

N. A. Medvedeva

О. С. Медведев

Abstract: Selenium is an important micronutrient that is essential for the functioning of the human body. Being a component of the active center of several antioxidant enzymes selenium prevents cell injury by free radicals. Decline in selenium-containing enzymes results in progression of oxidative stress and chronic inflammation, which are considered as possible causes for the development of many cardiovascular diseases. This review focuses on mechanisms for prevention of myocardial and vascular injury through the adequ… Show more

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Cited by 2 publications

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The use of selenium-containing drugs in the prevention and treatment of complications in patients with COVID-19

Dedov,

Poluboyarinov,

Fedorov

2023

Vrach

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Objective. To study literature data reflecting the use of selenium (Se) and selenium-containing drugs in the complex prophylaxis and treatment of complications in patients with COVID-19. Material and methods. Data analysis of 37 publications of scientists from Russian Federation, United States of America, People's Republic of China, Great Britain, India, France, Germany, Italy, Sweden, Canada, Brazil, United Arab Emirates, Saudi Arabia, Ireland, Holland, Greece, Australia, Poland, Pakistan, Sudan, Nepal was performed. The authors reflected on the epidemiology, diagnosis, pathogenesis, clinic, risk of acute respiratory distress syndrome, multiple organ failure, cardiovascular complications, mortality in patients with COVID-19, the importance of Se deficiency in the body and the preventive use of selenium-containing drugs in novel coronavirus infection. Results. Low dietary Se intake was associated with the development of acute respiratory distress syndrome in men and women with COVID-19. Deficiencies were associated with increased risk of morbidity and mortality. Organic forms of Se had the best bioavailability. Se had antioxidant, anti-inflammatory, antithrombotic, antiviral, immunomodulatory effects in patients with COVID-19. Conclusions. Thus, control and optimization of the selenium status in population of selenium-deficient areas with addition of Se-enriched food to the diet, as well as SELENBIO for women complex of Russian company "Parapharm" could be one of the directions of prevention and treatment of complications in patients with COVID-19.

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The use of selenium-containing drugs in the prevention and treatment of complications in patients with COVID-19

Dedov,

Poluboyarinov,

Fedorov

2023

Vrach

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Sex-Dependent Protective Effect of Combined Application of Solubilized Ubiquinol and Selenium on Monocrotaline-Induced Pulmonary Hypertension in Wistar Rats

et al. 2022

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Ubiquinol exhibits anti-inflammatory and antioxidant properties. Selenium is a part of a number of antioxidant enzymes. The monocrotaline inducible model of pulmonary hypertension used in this study includes pathological links that may act as an application for the use of ubiquinol with high bioavailability and selenium metabolic products. On day 1, male and female rats were subcutaneously injected with a water-alcohol solution of monocrotaline or only water-alcohol solution. On days 7 and 14, some animals were intravenously injected with either ubiquinol’s vehicle or solubilized ubiquinol, or orally with selenium powder daily, starting from day 7, or received both ubiquinol + selenium. Magnetic resonance imaging of the lungs was performed on day 20. Hemodynamic parameters and morphometry were measured on day 22. An increased right ventricle systolic pressure in relation to control was demonstrated in all groups of animals of both sexes, except the group of males receiving the combination of ubiquinol + selenium. The relative mass of the right ventricle did not differ from the control in all groups of males and females receiving either ubiquinol alone or the combination. Magnetic resonance imaging revealed impaired perfusion in almost all animals examined, but pulmonary fibrosis developed in only half of the animals in the ubiquinol group. Intravenous administration of ubiquinol has a protective effect on monocrotaline-induced pulmonary hypertension development resulting in reduced right ventricle hypertrophy, and lung mass. Ubiquinol + selenium administration resulted in a less severe increase in the right ventricle systolic pressure in male rats but not in females 3 weeks after the start of the experiment. This sex-dependent effect was not observed in the influence of ubiquinol alone.

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The role of selenium in cardiology

Cited by 2 publications

References 50 publications

The use of selenium-containing drugs in the prevention and treatment of complications in patients with COVID-19

The use of selenium-containing drugs in the prevention and treatment of complications in patients with COVID-19

Sex-Dependent Protective Effect of Combined Application of Solubilized Ubiquinol and Selenium on Monocrotaline-Induced Pulmonary Hypertension in Wistar Rats

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