The role of selected non-coding RNAs in the biology of non-small cell lung cancer

Time for micro-RNAs in steatotic liver disease: a case–control study

“…Micro-RNAs are small (18–22 nucleotides), non-coding RNAs possessing the unique feature of cleaving mRNA and silence translation. Their genesis comprises several steps: transcription of primitive miRNA from appropriate genes, cutting of pri-miRNA by RNase III Drosha and DiGeorge syndrome critical region 8 (DGCR8), export of the resulting pre-miRNA in the cytoplasm by Exportin 5, removal of the loop region by Dicer RNase III, and, after discarding one strand, the formation of a mature miRNA capable of inhibiting translation by binding to the untranslated regions of several target mRNAs known as MREs (miRNA response elements) ( 9 ).…”

Elucidating the anti-cancer potential of Cinnamomum tamala essential oil against non-small cell lung cancer: A multifaceted approach involving GC-MS profiling, network pharmacology, and molecular dynamics simulations

“…The MAPK pathway assumes a greater significance in processes such as cell proliferation, differentiation, apoptosis, angiogenesis, and tumor metastasis when compared to other cellular pathways [ 47 ]. MAPK signalling pathway is a distinct signalling pathway that regulates cell proliferation, cell cycle advancement and survival [ 48 ]. Boswellia sacra essential oil has been shown to down-regulate the MAPK signalling pathway to exert its anti-cancer effect in human breast cancer cells [ 49 ].…”

miR-199a-5p targets DUSP14 to regulate cell proliferation, invasion and stemness in non-small cell lung cancer

“…The miRNA refers to a type of single-stranded non-coding RNA regulating gene expression through binding to the 3′UTR region of target mRNAs [ 32 ]. An increasing number of evidence indicates that the deregulation of miRNAs is indicated in the initiation and progression of NSCLC [ 8 ]. Previous studies have shown that miR-9 and miR-155 can target DUSP14 in metastatic breast cancer [ 33 ].…”

“…Numerous studies have reported that miRNAs are important for tumor occurrence and development, like cell proliferation, apoptosis, migration, stemness, or other malignant processes [ 5 , 6 ]. miRNAs can play a role of oncogenes or tumor suppressors in NSCLC [ 7 , 8 ]. For instance, miR-199a-5p expression decreases within NSCLC, which is believed as the suppressor gene [ [9] , [10] , [11] , [12] ].…”