The role of seasonality on the chemical composition, antioxidant activity and cytotoxicity of Polish propolis in human erythrocytes

Woźniak, Magdalena; Mrówczyńska, Lucyna; Waśkiewicz, Agnieszka; Rogoziński, Tomasz; Ratajczak, Izabela

doi:10.1016/j.bjp.2019.02.002

Cited by 38 publications

(41 citation statements)

References 49 publications

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“…A high level of concentration was also detected for cinnamic acid. All identified aromatic acids in the propolis extract were previously detected in propolis samples collected from Poland [18,19,24]. The concentrations of catechin, epicatechin, genistein, pinostrobin, synaptic acid and syringic acid in the propolis extract were below the UPLC/PDA/TQD detection limits.…”

Section: Analysis Of Propolis Extract Compositionmentioning

confidence: 84%

“…Its chemical composition is complex and depends on the plant sources available to the bees in different geographical regions. Propolis contains various chemical compounds, such as phenols (flavonoids, phenolic acids and their esters), terpenoids, fatty acids, sugars, as well as mineral elements [16][17][18][19]. Phenolic compounds are biologically active components of propolis, which are mainly responsible for the pharmacological activity of propolis extracts [15,20].…”

Section: Introductionmentioning

confidence: 99%

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The Possibility of Propolis Extract Application in Wood Protection

Woźniak

Kwaśniewska-Sip

Waśkiewicz

et al. 2020

Forests

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Nowadays, there is a growing interest in extending the service life of wood and wood products by applying natural substances that are harmless to humans and the environment. In this paper, propolis was used as an eco-friendly wood preservative. The aim of this study was to determine the resistance of Scots pine wood treated with the propolis extract against brown-rot fungus Coniophora puteana. The wood biodegradation was assessed by gravimetric method, as well as by the analysis of ergosterol concentration in decayed wood and by the determination of changes in the wood structure by means of Fourier transform infrared spectroscopy. The results indicated that the impregnation of wood with propolis extract above 12% concentration limited fungal decay. The mass loss of wood treated with 18.9% propolis extract was 2.3% and was over 21 times lower than that for untreated wood. The analysis of ergosterol content and the changes in wood structure also confirmed that the propolis extract above 12% concentration protected wood against decay caused by C. puteana. Moreover, the propolis extract used in wood impregnation was rich in phenolic compounds, mainly chrysin, pinocembrin and galangin, which possess antimicrobial activity. The obtained results indicate that the extract of Polish propolis can be a promising natural wood preservative, safe for humans and the natural environment.

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Section: Analysis Of Propolis Extract Compositionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

The Possibility of Propolis Extract Application in Wood Protection

Woźniak

Kwaśniewska-Sip

Waśkiewicz

et al. 2020

Forests

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“…Phenolic compounds regularly determined in poplar-type propolis samples include pinocembrin, galangin, chrysin, kaempferol, catechin, quercetin, rutin, pinostrobin, pinobanksin, naringenin, caffeic acid, coumaric acid, ferulic acid, caffeic acid phenethyl ester, or caffeic acid cinnamyl ester [ 11 , 14 , 15 , 16 , 17 , 18 ]. Chrysin, galangin, and pinocembrin are common flavonoids identified in propolis samples from various regions of Poland [ 4 , 8 , 9 , 19 , 20 ]. In addition, hesperetin, apigenin, kaempferol, naringenin, pinobanksin, quercetin, and phenolic acids, including caffeic, coumaric, ferulic, vanillic, gallic, and genistic acids, have also been identified in Polish propolis [ 4 , 8 , 9 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…Chrysin, galangin, and pinocembrin are common flavonoids identified in propolis samples from various regions of Poland [ 4 , 8 , 9 , 19 , 20 ]. In addition, hesperetin, apigenin, kaempferol, naringenin, pinobanksin, quercetin, and phenolic acids, including caffeic, coumaric, ferulic, vanillic, gallic, and genistic acids, have also been identified in Polish propolis [ 4 , 8 , 9 , 19 , 20 , 21 ]. Fatty acids, ketones, enzymes, sterols, terpenes, minerals, and coumarins were also identified in propolis samples of various botanical origin [ 6 , 11 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…Over the past few years, the biological activities of Polish propolis were studied intensively, and its chemopreventive, antioxidant, antibacterial, antiproliferative, and antifungal activity was observed [ 4 , 5 , 8 , 9 , 30 , 31 , 32 , 33 ]. Moreover, propolis collected from an apiary located in the central–western part of Poland effectively protected human red blood cells (RBC) in vitro against 2,2′-azobis(2-methylpropionamidine) dihydrochloride (AAPH)-induced oxidative hemolysis [ 19 , 34 ]. To the best of our knowledge, the impact of the solvent used for the extraction of Polish propolis on its phenolic profile and the antifungal and antioxidant properties, especially on the protective effect of extracts against in vitro oxidative hemolysis of human erythrocytes, has not been reported to date.…”

Section: Introductionmentioning

confidence: 99%

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Effect of the Solvent on Propolis Phenolic Profile and its Antifungal, Antioxidant, and In Vitro Cytoprotective Activity in Human Erythrocytes Under Oxidative Stress

et al. 2020

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Propolis is a natural bee product with various beneficial biological effects. The health-promoting properties of propolis depend on its chemical composition, particularly the presence of phenolic compounds. The aim of this study was to evaluate the relationship between extraction solvent (acetone 100%, ethanol 70% and 96%) and the antifungal, antioxidant, and cytoprotective activity of the extracts obtained from propolis. Concentrations of flavonoids and phenolic acids in the propolis extracts were determined using ultrahigh-performance liquid chromatography. The antioxidant potential of different extracts was assessed on the basis of 2,2-diphenyl-1-picrylhydrazyl (DPPH·) free-radical-scavenging activity, Fe3+-reducing power, and ferrous ion (Fe2+)-chelating activity assays. The ability of the extracts to protect human red blood cell membranes against free-radical-induced damage and their antifungal activity was also determined. The results showed that the concentration of flavonoids in the propolis extracts was dependent on the solvent used in the extraction process and pinocembrin, chrysin, galangin, and coumaric acid were the most abundant phenols. All extracts exhibited high antioxidant potential and significantly protected human erythrocytes against oxidative damage. On the other hand, the antifungal activity of the propolis extracts depended on the solvent used in extraction and the fungal strains tested. It needs to be stressed that, to the best of our knowledge, there is no study relating the effect of solvent used for extraction of Polish propolis to its phenolic profile, and its antifungal, antioxidant, and cytoprotective activity.

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Chinese Propolis: Ultrasound‐assisted enhanced ethanolic extraction, volatile components analysis, antioxidant and antibacterial activity comparison

Ding

Sheikh

et al. 2020

Food Science & Nutrition

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This study was aimed to enhance the extraction yield of propolis samples using ultrasound technology, analyze the volatile compounds, and compare the antioxidant and antimicrobial effect of propolis extracts of different areas. Four propolis samples were collected from different regions of China, namely: Linqing, Shandong Province (LSP); Yingchun, Heilongjiang Province (YHP); Changge, Henan Province (CHP); and Raohe, Heilongjiang Province (RHP). The ultrasound extracts of CHP and RHP showed a higher total phenolic content (TPC) of 201.78 ± 4.60 mgGAE/g and 166.071 ± 1.53 mgGAE/g, total flavonoid content (TFC) of 519.77 ± 29.90 and 341.227 ± 10.82 mg quercetin/g respectively, as well as high antioxidant and antibacterial activity. Conventional extraction showed 15%–20% lower yield for TPC ranging from 72.02 ± 1.99 to 155.95 ± 3.69 mg GAE/g, TFC ranges from 129.675 ± 6.82 to 412.83 ± 12.14 mg quercetin/g, with lower antibacterial activity. The antioxidant activity of propolis extracts was determined by assays of reducing power, DPPH*, FRAP*, TEAC*, hydroxyl radical scavenging activity and superoxide anion scavenging activity. Collectively, the antioxidant activities of extracts from CHP and RHP were higher than those of the other two extracts(YHP and LSP). All the extracts showed high antimicrobial activity on Staphylococcus aureus, Listeria monocytogenes, and Bacillus subtilis, but no effect on Escherichia coli. A total of 150 compounds in propolis were detected by GC/MS. Terpenes (RHP 34%, YHP 5%, LSP 18%, and CHP 12%) and alcohols (RHP 12%, YHP 13%, LSP 12%, and CHP 10%) showed the highest relative content among all other extracts.

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The role of seasonality on the chemical composition, antioxidant activity and cytotoxicity of Polish propolis in human erythrocytes

Cited by 38 publications

References 49 publications

The Possibility of Propolis Extract Application in Wood Protection

The Possibility of Propolis Extract Application in Wood Protection

Effect of the Solvent on Propolis Phenolic Profile and its Antifungal, Antioxidant, and In Vitro Cytoprotective Activity in Human Erythrocytes Under Oxidative Stress

Chinese Propolis: Ultrasound‐assisted enhanced ethanolic extraction, volatile components analysis, antioxidant and antibacterial activity comparison

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