The role of Schmidt-Lanterman incisures in Wallerian degeneration

The Schwann Cell-Axon Link in Normal Condition or Neuro-Degenerative Diseases: An Immunocytochemical Approach

“…These glial "shortcut" have been largely described in literature. The internodes SLI's number varies, depending on the species, axonal diameter and physiological conditions (Cajal, 1928, Ghabriel, et al, 1979aand b, 1980aand b, 1981Hiscoe, 1947;MacKenzie et al, 1984;Robertson, 1958,). In the present work SLI have been characterized throughout the molecular expression of cytoskeleton components (actin, tubulin, vimentin) and adhesion molecules (MAG), showing that the SLI cytoplasm have well organized "roads" devoted to traffic.…”

Effects of Nucleus Pulposus on Nerve Root Neural Activity, Mechanosensitivity, Axonal Morphology, and Sodium Channel Expression

“…Our data showed that application of NP in epidural space induced neuropathic changes in myelin sheaths and SLIs 15,22,23 (Figure 9B through 9D). The number of SLIs with pathologic changes increased in 7 days' and 21 days' NP exposed nerve roots.…”

Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice

“…This approach also has been applied to the examination of pathological alterations in fibres undergoing axonal degeneration (Bouldin and Cavanagh, 1979;Ghabriel and Allt, 1979;Knowles, 1978;Lubinska, 1977;Mastalgia et al, 1976;Oldfors, 1981). Serial longitudinal sectioning of resin embedded nerve tissue and tedious subsequent three-dimensional reconstruction could also in theory be used to investigate the course and structure of individual fibres (Fraher, 1978a,b;Friede and Martinez, 1970;Kidd and Heath, 1988;Tuisku and Hildebrand, 1992), but mostly it is impossible to preserve the orientation of nerves with sufficient precision to show even two complete internodes.…”