The role of S100A4 gene encoding an S100-related calcium-binding protein in human bile duct adenocarcinoma cell lines: correlation of S100A4 expression and invasive growth in Matrigel Matrix.

Katayama, Naoya; Murao, Shinichi; Ajiki, Tetsuo; Kitazawa, Sohei; Onoyama, Hirohiko; Kuroda, Yoshikazu; Maeda, Sakan

doi:10.3892/ijmm.6.5.539

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“…This molecule has been linked to increased metastasis; its expression levels strongly correlate with the invasive and metastatic behavior of cultured tumor cells (4)(5)(6)8). In addition, S100A4 expression correlated with lymph node metastasis and prognosis in clinical studies of multiple cancers (7)(8)(9)(10).…”

Section: Discussionmentioning

confidence: 99%

“…Investigation of the molecules associated with regional lymph nodes metastasis and poor prognosis in patients with SCC would be useful in recognizing tumor behavior, accurately predicting prognosis, and increasing the ability to determine the most appropriate therapies for each patient. In recent years, S100A4, a member of the S100 calcium-binding protein family, has been associated with increased metastases; S100A4 expression correlates strongly with invasive and metastatic behavior of cultured tumor cells, including colorectal adenocarcinoma (4), bile duct adenocarcinoma (5), and human squamous cell carcinoma (6). In clinical research, elevated expression of S100A4 has been connected with metastasis and poor prognosis in breast cancer (7,8), non-small cell lung cancer (NSCLC) (9), gallbladder cancer (10), and esophageal squamous cell carcinoma (11).…”

Section: Introductionmentioning

confidence: 99%

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The Evaluation of both Metastasis and Prognosis of Oral Squamous Cell Carcinoma by S100A4 and E-cadherin Immunostaining

et al. 2004

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Using immunohistochemistry, we studied the expression of S100A4 and E-cadherin in 43 oral squamous cell carcinomas (SCC) to evaluate the metastatic potential and patient survival.Expression levels of S100A4 correlated with lymph node metastasis (P=0.024) and poor prognosis (P=0.0136). Reduced E-cadherin expression was also associated with lymph node metastasis (P=0.023) and poor prognosis (P=0.0146) and was inversely correlated with S100A4 expression (P=0.011). We also found that S100A4(2+,3+)/E-cadherin(-,+) expression was significantly associated with lymph node metastasis (P=0.04) and poor prognosis (P=0.0021). Furthermore, we systematized the evaluation of oral SCC metastasis and prognosis by analyzing the expression of S100A4, E-cadherin, and other histopathological factors. Cases with total points greater than 8 were associated with lymph node metastasis (P=0.000) and poor prognosis (P=0.0022). These results indicate that S100A4, as both a single factor and in combination with E-cadherin, may be one of the most useful markers predicting the metastatic potential and prognosis of oral SCC patients.

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