“…Investigation of the molecules associated with regional lymph nodes metastasis and poor prognosis in patients with SCC would be useful in recognizing tumor behavior, accurately predicting prognosis, and increasing the ability to determine the most appropriate therapies for each patient. In recent years, S100A4, a member of the S100 calcium-binding protein family, has been associated with increased metastases; S100A4 expression correlates strongly with invasive and metastatic behavior of cultured tumor cells, including colorectal adenocarcinoma (4), bile duct adenocarcinoma (5), and human squamous cell carcinoma (6). In clinical research, elevated expression of S100A4 has been connected with metastasis and poor prognosis in breast cancer (7,8), non-small cell lung cancer (NSCLC) (9), gallbladder cancer (10), and esophageal squamous cell carcinoma (11).…”