The role of S100 proteins and their receptor RAGE in pancreatic cancer

Leclerc, Estelle; Vetter, Stefan

doi:10.1016/j.bbadis.2015.09.022

Cited by 70 publications

(59 citation statements)

References 50 publications

(112 reference statements)

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“…In IPMNs, the levels of expression of several members of this family, such as S100P, are highly elevated in bulk pancreatic tissues, than in non-neoplastic pancreatic tissues. Furthermore, in micro-dissected cells, S100P expression is reported to be increased in pancreatic ductal adenocarcinoma in relation to IPMN cells (56,59). Interestingly, in pancreatic juice, S100P is highly expressed in IPMNs in relation to chronic pancreatitis (60).…”

Section: Current Practice and The Updates On The Genomic Fieldmentioning

confidence: 95%

Updates and Critical Evaluation on Novel Biomarkers for the Malignant Progression of Intraductal Papillary Mucinous Neoplasms of the Pancreas

Moris

Damaskos

Spartalis

et al. 2017

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Section: Current Practice and The Updates On The Genomic Fieldmentioning

confidence: 95%

Updates and Critical Evaluation on Novel Biomarkers for the Malignant Progression of Intraductal Papillary Mucinous Neoplasms of the Pancreas

Moris

Damaskos

Spartalis

et al. 2017

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“…307, 308, 309 The role of S100 proteins in cancer is considered to be type and stage specific, and each type of cancer seems to exhibit a different S100 protein profile. 307 Several groups recently reviewed the intricate role of S100 proteins in cancer in great detail.…”

Section: S100mentioning

confidence: 99%

“…307 Several groups recently reviewed the intricate role of S100 proteins in cancer in great detail. 307, 308, 309 …”

Section: S100mentioning

confidence: 99%

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

2016

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Our immune system is based on the close collaboration of the innate and adaptive immune systems for the rapid detection of any threats to the host. Recognition of pathogen-derived molecules is entrusted to specific germline-encoded signaling receptors. The same receptors have now also emerged as efficient detectors of misplaced or altered self-molecules that signal tissue damage and cell death following, for example, disruption of the blood supply and subsequent hypoxia. Many types of endogenous molecules have been shown to provoke such sterile inflammatory states when released from dying cells. However, a group of proteins referred to as alarmins have both intracellular and extracellular functions which have been the subject of intense research. Indeed, alarmins can either exert beneficial cell housekeeping functions, leading to tissue repair, or provoke deleterious uncontrolled inflammation. This group of proteins includes the high-mobility group box 1 protein (HMGB1), interleukin (IL)-1α, IL-33 and the Ca2+-binding S100 proteins. These dual-function proteins share conserved regulatory mechanisms, such as secretory routes, post-translational modifications and enzymatic processing, that govern their extracellular functions in time and space. Release of alarmins from mesenchymal cells is a highly relevant mechanism by which immune cells can be alerted of tissue damage, and alarmins play a key role in the development of acute or chronic inflammatory diseases and in cancer development.

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“…The immunohistochemical analysis confirmed the expression of RAGE and its ligands S100P, S100A4, and HMGB-1 in human PDA [56]. RAGE and S100 protein play important roles in the progression of PDA [55]. Indeed, S100 proteins interact with RAGE, which play a role in the degradation of the extracellular matrix facilitating the metastasis of pancreatic cancer [57].…”

Section: Rage and Pancreatic Cancermentioning

confidence: 61%

“…PDA is a wasteful disease with low survival rates [55]. Loss of RAGE function inhibited the development of PDA in mouse models [3].…”

Section: Rage and Pancreatic Cancermentioning

confidence: 99%

The Role of Receptors for Advanced Glycation End Product in Pancreatic Carcinogenesis

El‐Far

2016

Pancreat Disord Ther

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Pancreatic cancer is the fourth-leading cause of cancer deaths worldwide that considered as the malignant tumor with the poorest prognosis and the lowest survival rate. This extremely violent disease is rarely diagnosed at an early level and difficult to treat due to its resistance to radiation therapy and chemotherapy. Here, we show that the receptor for advanced glycation end products (RAGE) and its ligands, advanced glycation end products (AGEs), high-mobility group box 1 (HMGB1) and S100 protein family are required for pancreatic cancer development, angiogenesis and metastasis through up-regulation of some anti-apoptotic molecules as matrix metalloproteinase -9 (MMP-9), kinase insert domain receptor (KDR), vascular endothelial growth factor (VEGF), platelet-derived growth factor-B (PDGF-B), hypoxia-inducible factor 1 (HIF1α), signal transducer and activator of transcription 3 (pSTAT3) and nuclear factor kappa B (NF-κB). In addition to the decrease in reactive oxygen species (ROS) those favouring the cancer cell growth and metastasis. The role of RAGE in pancreatic carcinogenesis needs further studies to investigate the relationship of RAGE with other anti-apoptotic and apoptotic molecules and examine the therapeutic potentials of anti-RAGE drugs for pancreatic cancer.

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The role of S100 proteins and their receptor RAGE in pancreatic cancer

Cited by 70 publications

References 50 publications

Updates and Critical Evaluation on Novel Biomarkers for the Malignant Progression of Intraductal Papillary Mucinous Neoplasms of the Pancreas

Updates and Critical Evaluation on Novel Biomarkers for the Malignant Progression of Intraductal Papillary Mucinous Neoplasms of the Pancreas

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

The Role of Receptors for Advanced Glycation End Product in Pancreatic Carcinogenesis

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