The role of rTMS for patients with severe PTSD and depression

Fryml, Leah; Sahlem, Gregory L.; Fox, James; Short, E. Baron

doi:10.1136/eb-2017-102819

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…Overall, we collected 4 case-series studies, assessing the effectiveness of standard or accelerated rTMS. Accelerated TMS (18 Hz, 1980 pulses per session, 4 sessions per day, 5 sessions for a week for a month) was used by Fryml et al (Fryml et al, 2018) in a TRD unipolar post-traumatic stress disorder (PTSD) 27 year old patient. the authors reported that at 4-weeks post-treatment follow-up suicidal thoughts disappeared and PTSD/depressive were improved.…”

Section: Case Reports and Case Seriesmentioning

confidence: 99%

Effects of repetitive transcranial magnetic stimulation on suicidal behavior: A systematic review

Serafini

Canepa

Aguglia

et al. 2021

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Case Reports and Case Seriesmentioning

confidence: 99%

Effects of repetitive transcranial magnetic stimulation on suicidal behavior: A systematic review

Serafini

Canepa

Aguglia

et al. 2021

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Several non-invasive neuromodulation technologies, such as electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), are used as treatments for severe MDD, but there is no conclusive evidence that they are able to reduce specific symptoms in PTSD [ 228 , 229 ]. Several studies reported that these neuromodulations can produce effective treatments in patients with refractory depression and co-occurring PTSD [ 230 ], [ 231 ], [ 232 ]. Deep brain stimulation (DBS) is an invasive neuromodulation that has been approved to reduce symptoms in movement disorders, such as Parkinson’s disease, essential tremor, and dystonia [ 233 , 234 ].…”

Section: Neuromodulationmentioning

confidence: 99%

Post-traumatic stress disorder: a psychiatric disorder requiring urgent attention

Diao

Zhou

et al. 2022

Medical Review

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Post-traumatic stress disorder (PTSD) is a severe and heterogenous psychiatric disorder that was first defined as a mental disorder in 1980. Currently, the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) and the International Classification of Diseases 11th Edition (ICD-11) offer the most widely accepted diagnostic guidelines for PTSD. In both diagnostic categories, experiencing a traumatic event (TE) is the necessary criterion for diagnosing PTSD. The TEs described in the DSM-5 include actual or threatened death, serious injury, sexual violence, and other extreme stressors, either directly or indirectly. More than 70% of adults worldwide are exposed to a TE at least once in their lifetime, and approximately 10% of individuals develop PTSD after experiencing a TE. The important features of PTSD are intrusion or re-experiencing fear memories, pervasive sense of threat, active avoidance, hyperarousal symptoms, and negative alterations of cognition and mood. Individuals with PTSD have high comorbidities with other psychiatric diseases, including major depressive disorder, generalized anxiety disorder, and substance use disorder. Multiple lines of evidence suggest that the pathophysiology of PTSD is complex, involving abnormal neural circuits, molecular mechanisms, and genetic mechanisms. A combination of both psychotherapy and pharmacotherapy is used to treat PTSD, but has limited efficacy in patients with refractory PTSD. Because of the high prevalence, heavy burden, and limited treatments, PTSD is a psychiatric disorder that requires urgent attention. In this review, we summarize and discuss the diagnosis, prevalence, TEs, pathophysiology, and treatments of PTSD and draw attention to its prevention.

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“…The typical locus of stimulation was the dorsolateral prefrontal cortex, either unilaterally (right or left) or bilaterally. Stimulation frequencies have largely varied from 1 to 20 Hz and motor thresholds (MT) have varied from 80% to 120% [29,86,87,88,89,90,91,92,93,94]. All studies but one [90] have reported an improvement of PTSD symptoms (i.e., measured with the PTSD Checklist-Military Version, PCL-M; PTSD Checklist-Civilian Version, PCL-C; PTSD Checklist for DSM-5; or Clinician Administered PTSD Scale, CAPS).…”

Section: Neuromodulation Studies In Clinical Practicementioning

confidence: 99%

“…Stimulation frequencies have largely varied from 1 to 20 Hz and motor thresholds (MT) have varied from 80% to 120% [29,86,87,88,89,90,91,92,93,94]. All studies but one [90] have reported an improvement of PTSD symptoms (i.e., measured with the PTSD Checklist-Military Version, PCL-M; PTSD Checklist-Civilian Version, PCL-C; PTSD Checklist for DSM-5; or Clinician Administered PTSD Scale, CAPS). One episode featuring a severe adverse event (tonic-clonic generalized seizure) and a few mild adverse events (headache, dizziness) have been reported [29,87,88,89,90,91,92,93,94].…”

Section: Neuromodulation Studies In Clinical Practicementioning

confidence: 99%

Neuromodulation Strategies in Post-Traumatic Stress Disorder: From Preclinical Models to Clinical Applications

et al. 2019

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Post-traumatic stress disorder (PTSD) is an often debilitating disease with a lifetime prevalence rate between 5–8%. In war veterans, these numbers are even higher, reaching approximately 10% to 25%. Although most patients benefit from the use of medications and psychotherapy, approximately 20% to 30% do not have an adequate response to conventional treatments. Neuromodulation strategies have been investigated for various psychiatric disorders with promising results, and may represent an important treatment option for individuals with difficult-to-treat forms of PTSD. We review the relevant neurocircuitry and preclinical stimulation studies in models of fear and anxiety, as well as clinical data on the use of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and deep brain stimulation (DBS) for the treatment of PTSD.

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The role of rTMS for patients with severe PTSD and depression

Cited by 5 publications

References 5 publications

Effects of repetitive transcranial magnetic stimulation on suicidal behavior: A systematic review

Effects of repetitive transcranial magnetic stimulation on suicidal behavior: A systematic review

Post-traumatic stress disorder: a psychiatric disorder requiring urgent attention

Neuromodulation Strategies in Post-Traumatic Stress Disorder: From Preclinical Models to Clinical Applications

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