The Role of Rituximab in Lymphomas

Coiffier, Bertrand

doi:10.1590/s1516-84842002000300004

Cited by 1 publication

(3 citation statements)

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“…After two years, comparison of R-CHOP and CHOP alone showed 57% versus 38% survival rates free of events, 70% versus 57% overall survival, and 52% versus 37% complete response, respectively, favoring the R-CHOP therapy (Coiffier, 2002). After 5 years, these rates remained significantly higher for the group with rituximab (Feugier et al, 2005).…”

Section: Results On the Clinical Efficacy Of Rituximabmentioning

confidence: 96%

“…According to Coiffier (2002), the response to rituximab in B cell lymphomas remained for around 2 months, with detectable residual levels up to 6 months after the last infusion, indicating a long half-life of the antibody in circulation. During this period, normal B cell population declined and was recovered after 6 months, however, there were no opportunistic infections or an increase in infection rates since the amount of antibodies and T cells remained normal.…”

Section: Results On the Clinical Efficacy Of Rituximabmentioning

confidence: 99%

“…CD20 has been shown to be a suitable tumor marker, since it is found in mature normal and tumor B cells (Van Der Kolk et al, 2002); it is overexpressed in tumor B cells; it does not circulate free in plasma, which would inhibit antibody binding to lymphoma cells; it is membrane-stable; it remains attached to the cell surface after antibody binding and it is not internalized by the cells (Coiffier, 2002).…”

Section: Inhibitory Mechanisms Of Cell Proliferationmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and economic aspects of the use of rituximab in non-Hodgkin's lymphoma

Figueirêdo

Souza

Soares³

et al. 2014

Braz. J. Pharm. Sci.

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Non-Hodgkin's lymphoma (NHL) consists of a group of neoplasias involving mainly B cells and represents 90% of all lymphomas. The current available therapy is based on chemotherapy associated with the monoclonal antibody rituximab (Mab Thera ® ), which targets the CD20 protein, present in over 80% of NHL mature B cells. Recent clinical reports show a preference for combining the benefits of immunotherapy and adjuvant chemotherapy, thus generating safe and effective alternative treatments. The current review aimed at evaluating various aspects related to the use of rituximab for NHL, highlighting the possible inhibitory mechanisms of cell proliferation, the achieved clinical results, and the expected clinical and economic outcomes of treatments. The results from clinical tests indicate the need for a better understanding of the critical mechanisms of action of this antibody, which may maximize its therapeutic efficacy. This therapy not only represents a viable option to treat most types of NHLs, especially when associated with conventional chemotherapy, but also offers cost-utility and cost-effectiveness advantages.Uniterms: Non-Hodgkin's lymphoma. Antineoplastic combined chemotherapy/protocols. Adjuvant chemotherapy. Rituximab/application/Non-Hodgkin's lymphoma.O Linfoma não-Hodgkin (LNH) consiste em um grupo de neoplasias envolvendo, principalmente, as células B e representa 90% de todos os linfomas. A terapia atual disponível é baseada em quimioterapia associada ao anticorpo monoclonal rituximabe (Mab Thera ® ), que tem como alvo a proteína CD20, presente em mais de 80% das células B maduras do LNH. Recentes relatórios clínicos mostram preferência para combinar os benefícios da quimioterapia adjuvante e imunoterapia, gerando alternativas de tratamentos seguro e eficaz. O trabalho de revisão teve por objetivo avaliar vários aspectos relacionados à aplicação do rituximabe no LNH, destacando os possíveis mecanismos inibitórios da proliferação celular, os resultados clínicos obtidos e as implicações clínicas e econômicas esperadas para o tratamento. Os resultados de testes clínicos indicam a necessidade de uma melhor compreensão dos mecanismos críticos de ação deste anticorpo, que poderão maximizar a sua eficácia terapêutica. Essa terapia não representa apenas uma opção viável para o tratamento da maioria dos tipos de LNH, principalmente quando associado à quimioterapia convencional, mas, também, oferece vantagens em termos de custoutilidade e custo-efetividade.Unitermos: Linfoma não-Hodgkin. Quimioterapia combinada antineoplásica/protocolos. Quimioterapia adjuvante. Ribuximabe/aplicação/Linfoma não-Hodgkin.

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Section: Results On the Clinical Efficacy Of Rituximabmentioning

confidence: 96%

Section: Results On the Clinical Efficacy Of Rituximabmentioning

confidence: 99%