The role of retinoic acid in the production of immunoglobulin A

Bos, Amelie; Egmond, Marjolein van; Mebius, Reina E.

doi:10.1038/s41385-022-00509-8

Cited by 19 publications

(20 citation statements)

References 163 publications

(229 reference statements)

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“…Vitamin A is of central importance for mucosal immunity, which is reviewed in detailed elsewhere [390][391][392] with only some basic immune mechanistic aspects given here.…”

Section: Vitamin a And Immunitymentioning

confidence: 99%

“…Similarly to iron deficiency, vitamin A deficiency leads initially to a Th1 response, giving rise to the production of IFNγ 85,86 and negatively affecting the antibody response, with persistent deficiency resulting in a Th2‐biased 402,403 and elevated IgE levels in vivo 402 . Vitamin A and vitamin D seems to be required for IgA antibody production 391 with a lack in retinoic acid signaling abrogating antigen‐specific IgA responses in B cells and affecting the microbiota composition 404 . Retinoic acid promotes the expansion of innate lymphoid cell ILC3s and enables dendritic cells to produce retinoic acid for T‐regulatory cells differentiation 405 .…”

Section: Vitamin Amentioning

confidence: 99%

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Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Roth‐Walter,

Berni Canani,

O'Mahony

et al. 2023

Allergy

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Nutritional Immunity is one of the most ancient innate immune responses, during which the body can restrict nutrients availability to pathogens and restricts their uptake by the gut mucosa (mucosal block). Though this can be a beneficial strategy during infection, it also is associated with non‐communicable diseases—where the pathogen is missing; leading to increased morbidity and mortality as micronutritional uptake and distribution in the body is hindered. Here, we discuss the acute immune response in respect to nutrients, the opposing nutritional demands of regulatory and inflammatory cells and particularly focus on some nutrients linked with inflammation such as iron, vitamins A, Bs, C, and other antioxidants. We propose that while the absorption of certain micronutrients is hindered during inflammation, the dietary lymph path remains available. As such, several clinical trials investigated the role of the lymphatic system during protein absorption, following a ketogenic diet and an increased intake of antioxidants, vitamins, and minerals, in reducing inflammation and ameliorating disease.

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“…Vitamin A is of central importance for mucosal immunity, which is reviewed in detailed elsewhere [390][391][392] with only some basic immune mechanistic aspects given here.…”

Section: Vitamin a And Immunitymentioning

confidence: 99%

Section: Vitamin Amentioning

confidence: 99%

Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Roth‐Walter,

Berni Canani,

O'Mahony

et al. 2023

Allergy

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“…Retinoic acid (RA) is reported to imprint gut homing in T cells (66, 67) and – as recently reviewed – to control IgA switch in B cells (68). As reported in these studies, mucosal subsets of myeloid cells appear to be specialized to produce RA, reflected by their unique expression of required enzymes.…”

Section: Resultsmentioning

confidence: 99%

Single-cell transcriptomics reveals striking heterogeneity and functional organization of dendritic and monocytic cells in the bovine mesenteric lymph node

Barut

Kreuzer

Bruggmann

et al. 2022

Preprint

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Dendritic and monocytic cells co-operate to initiate and shape adaptive immune responses in secondary lymphoid tissue. The complexity of this system is poorly understood, also because of the high phenotypic and functional plasticity of monocytic cells. We have sequenced mononuclear phagocytes in mesenteric lymph nodes (LN) of three adult cows at the single-cell level, revealing ten dendritic-cell (DC) clusters and seven monocyte/macrophage clusters with clearly distinct transcriptomic profiles. Among DC, we defined LN-resident subsets and their progenitors, as well as subsets of highly activated migratory DC differing in transcript levels for T-cell attracting chemokines. Our analyses also revealed a potential differentiation path for cDC2, resulting in a cluster of inflammatory cDC2 with close transcriptional similarity to putative DC3 and monocyte-derived DC. Monocytes and macrophages displayed sub-clustering mainly driven by pro- or anti-inflammatory expression signatures, including a small cluster of cycling, presumably self-renewing, macrophages.With this transcriptomic snapshot of LN-derived mononuclear phagocytes, we reveal functional properties and differentiation trajectories in a “command center of immunity” that are likely to be conserved across species.

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“…This functional complexity requires a highly organized tissue architecture, via integrating divergent epithelial components, smooth muscle layers, lymphatic and blood vasculature, autonomous innervation, and mucosal lymphoid tissues that can also maintain tissue integrity and a balanced intestinal microbiome composition. [1][2][3][4] The synchronized development of the gut involves the differentiation of several types of cells with diverse origins. Epithelial cells develop from the endoderm and, following embryonic specialization, undergo continuous renewal and specification from Lgr5 + epithelial stem cells, located at the bottom of intestinal crypts.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of NKX2-3 Expression in Human Colon: An Immunohistochemical Study

Gábris,

Kajtár,

Kellermayer

et al. 2023

J Histochem Cytochem.

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In mice, Nkx2-3 homeodomain transcription factor defines the vascular specification of secondary and tertiary lymphoid tissues of the intestines. In human studies, polymorphisms in NKX2-3 have been identified as a susceptibility factor in inflammatory bowel diseases, whereas in mice, its absence is associated with protection against experimental colitis and enhanced intestinal epithelial proliferation. Here, we investigated the expression of NKX2-3 in normal, polyp, and adenocarcinoma human colon samples using immunohistochemistry and quantitative morphometry, correlating its expression with endothelial and mesenchymal stromal markers. Our results revealed that the expression of NKX2-3 is regionally confined to the lamina propria and lamina muscularis mucosae, and its production is restricted mostly to endothelial cells and smooth muscle cells with variable co-expression of CD34, alpha smooth muscle antigen (αSMA), and vascular adhesion protein-1 (VAP-1). The frequency of NKX2-3-positive cells and intensity of expression correlated inversely with aging. Furthermore, in most colorectal carcinoma samples, we observed a significant reduction of NKX2-3 expression. These findings indicate that the NKX2-3 transcription factor is produced by both endothelial and non-endothelial tissue constituents in the colon, and its expression changes during aging and in colorectal malignancies. (J Histochem Cytochem XX: XXX–XXX, XXXX)

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The role of retinoic acid in the production of immunoglobulin A

Cited by 19 publications

References 163 publications

Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Nutrition in chronic inflammatory conditions: Bypassing the mucosal block for micronutrients

Single-cell transcriptomics reveals striking heterogeneity and functional organization of dendritic and monocytic cells in the bovine mesenteric lymph node

Quantitative Analysis of NKX2-3 Expression in Human Colon: An Immunohistochemical Study

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