The role of resveratrol on rheumatoid arthritis: From bench to bedside

Sheng, Shuyan; Wang, Xinyi; Liu, Xin; Hu, Xinyang; Shao, Yubao; Wang, Gaoyuan; Mao, Deshen; Li, Conghan; Chen, Bangjie; Chen, Xiaoyu

doi:10.3389/fphar.2022.829677

Cited by 19 publications

(9 citation statements)

References 93 publications

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“…In addition to the role of RES in protecting cells from autoimmune responses to poly I:C [ 22 , 35 , 36 , 37 ], we asked whether the antioxidant could also rescue the downstream effects of other types of cellular stressors. For the rest of the investigation, we switched the experimental system to the HCT116 colorectal carcinoma cell line because ROS production and the subsequent oxidative stress are often associated with colorectal cancer progression [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Resveratrol Attenuates the Mitochondrial RNA-Mediated Cellular Response to Immunogenic Stress

Yoon

Lee

et al. 2023

IJMS

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Human mitochondria contain a circular genome that encodes 13 subunits of the oxidative phosphorylation system. In addition to their role as powerhouses of the cells, mitochondria are also involved in innate immunity as the mitochondrial genome generates long double-stranded RNAs (dsRNAs) that can activate the dsRNA-sensing pattern recognition receptors. Recent evidence shows that these mitochondrial dsRNAs (mt-dsRNAs) are closely associated with the pathogenesis of human diseases that accompany inflammation and aberrant immune activation, such as Huntington’s disease, osteoarthritis, and autoimmune Sjögren’s syndrome. Yet, small chemicals that can protect cells from a mt-dsRNA-mediated immune response remain largely unexplored. Here, we investigate the potential of resveratrol (RES), a plant-derived polyphenol with antioxidant properties, on suppressing mt-dsRNA-mediated immune activation. We show that RES can revert the downstream response to immunogenic stressors that elevate mitochondrial RNA expressions, such as stimulation by exogenous dsRNAs or inhibition of ATP synthase. Through high-throughput sequencing, we find that RES can regulate mt-dsRNA expression, interferon response, and other cellular responses induced by these stressors. Notably, RES treatment fails to counter the effect of an endoplasmic reticulum stressor that does not affect the expression of mitochondrial RNAs. Overall, our study demonstrates the potential usage of RES to alleviate the mt-dsRNA-mediated immunogenic stress response.

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Section: Resultsmentioning

confidence: 99%

Resveratrol Attenuates the Mitochondrial RNA-Mediated Cellular Response to Immunogenic Stress

Yoon

Lee

et al. 2023

IJMS

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“…Due to their multifaceted pharmacological effect, natural compounds including curcumin, 5 resveratrol, 6 gingerol, 7 corynoline, 8 rhoifolin, 9 and others have shown substantial benefits against RA. These compounds showed potent biological activity against numerous human diseases-including cancer, diabetes, cardiovascular disorders, and infectious and viral diseases.…”

Section: Introductionmentioning

confidence: 99%

Mechanistic Evaluation of Antiarthritic Effects of Eupatilin in CFA-Induced Arthritic Rats: An in Vivo and in Silico Study

Wang,

Liu,

Zhang

et al. 2024

Natural Product Communications

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Objectives In the present study, we explored the antiarthritic potential of Eupatilin on complete Freund's adjuvant (CFA)-induced arthritis rats. Materials and Methods In order to induce arthritis in the Sprague-Dawley rats, CFA vaccination was used, and Eupatilin was given to the rats at dose of 5, 10, and 20 mg/kg. Various biochemical and other parameters were studied to define the pharmacological benefit of Eupatilin. Results The study's findings revealed that Eupatilin increases rats’ body weight and significantly reduces hind paw volume. It also improves the antioxidant status of CFA rats by lowering malondialdehyde levels and increasing the concentration of endogenous antioxidants superoxide dismutase and GPx. Eupatilin also improved hematological markers, which were demonstrated to be altered in CFA rats as compared to the control. In the Eupatilin-treated group, the level of pro-inflammatory cytokines was found to be reduced as compared to CFA rats. In a molecular docking analysis, it showed favorable interaction with the active site of cyclooxygenase-2 (COX-2) by the formation of numerous nonbonded interactions by interacting with Cys32, Leu138, Pro 139, Val141, Ala142, and Cys145. It also showed a Vina score of −9.4 and interacts with the cavity volume of 4435 Å3. Conclusion Eupatilin showed favorable antiarthritic benefits in the CFA-induced arthritis model, as evidenced by reductions in paw volume, significant weight loss prevention, and maintenance of the healthy hematological and biochemical profile may be through inhibiting COX-2.

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“…Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease whose main pathological features are synovitis with swelling, cartilage destruction and pannus [ 1 ]. RA is associated with progressive disability, systemic complications, early mortality, and increased socioeconomic costs [ 2 ], among which systemic complications mainly include cardiovascular disease [ 3 ], pulmonary interstitial lesions [ 4 ], joint deformities [ 5 ], malignancies [ 6 ], and depression [ 7 ]. Epidemiological findings show that the global incidence of RA is 0.5%—1.0%, and the male to female ratio is approximately 1:4 [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of ferroptosis related markers by integrated bioinformatics analysis and In vitro model experiments in rheumatoid arthritis

Xia

Zhang

et al. 2023

BMC Med Genomics

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Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by destructive and symmetrical joint diseases and synovitis. This research attempted to explore the mechanisms involving ferroptosis in RA, and find the biological markers by integrated analysis. Methods Gene expression data (GSE55235 and GSE55457) of synovial tissues from healthy and RA individuals were downloaded. By filtering the differentially expressed genes (DEGs) and intersecting them with the 484 ferroptosis-related genes (FRGs), the overlapping genes were identified. After the enrichment analysis, the machine learning-based approaches were introduced to screen the potential biomarkers, which were further validated in other two datasets (GSE77298 and GSE93272) and cell samples. Besides, we also analyze the infiltrating immune cells in RA and their correlation with the biomarkers. Results With the criteria, 635 DEGs in RA were included, and 29 of them overlapped in the reported 484 FRGs. The enrichments of the 29 differentially expressed ferroptosis-related genes indicated that they may involve in the FoxO signaling pathway and inherited metabolic disorder. RRM2, validating by the external datasets and western blot, were identified as the biomarker with the high diagnostic value, whose associated immune cells, such as Neutrophils and Macrophages M1, were also further evaluated. Conclusion We preliminary explored the mechanisms between ferroptosis and RA. These results may help us better comprehend the pathophysiological changes of RA in basic research, and provide new evidences for the clinical transformation.

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The role of resveratrol on rheumatoid arthritis: From bench to bedside

Cited by 19 publications

References 93 publications

Resveratrol Attenuates the Mitochondrial RNA-Mediated Cellular Response to Immunogenic Stress

Resveratrol Attenuates the Mitochondrial RNA-Mediated Cellular Response to Immunogenic Stress

Mechanistic Evaluation of Antiarthritic Effects of Eupatilin in CFA-Induced Arthritic Rats: An in Vivo and in Silico Study

Identification of ferroptosis related markers by integrated bioinformatics analysis and In vitro model experiments in rheumatoid arthritis

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