The Role of Resveratrol in Mammalian Reproduction

Abstract

Resveratrol is one of the most investigated natural polyphenolic compounds and is contained in more than 70 types of plants and in red wine. The widespread interest in this polyphenol derives from its antioxidant, anti-inflammatory and anti-aging properties. Several studies have established that resveratrol regulates animal reproduction. However, the mechanisms of action and the potential therapeutic effects are still unclear. This review aims to clarify the role of resveratrol in male and female reproductive functions, with a focus on animals of veterinary interest. In females, resveratrol has been considered as a phytoestrogen due to its capacity to modulate ovarian function and steroidogenesis via sirtuins, SIRT1 in particular. Resveratrol has also been used to enhance aged oocyte quality and as a gametes cryo-protectant with mainly antioxidant and anti-apoptotic effects. In males, resveratrol enhances testes function and spermatogenesis through activation of the AMPK pathway. Furthermore, resveratrol has been supplemented to semen extenders, improving the preservation of sperm quality. In conclusion, resveratrol has potentially beneficial effects for ameliorating ovarian and testes function.

Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols

“…Our data reveal some similarities between the effects observed after NRG and RESV treatment. Some studies reported that RESV acts as a regulator of male reproductive function [ 78 , 79 ] and it has been suggested that RESV arguably improves semen quality in humans [ 80 ] when this molecule is added to a cryopreservation medium.…”

Preconceptional Resveratrol Supplementation Partially Counteracts Age-Related Reproductive Complications in C57BL/6J Female Mice

“…Considering the increasing trends toward delaying childbearing, there is a growing interest in establishing prophylactic and therapeutic strategies to counteract age-related reproductive failure. RES has been indicated as an anti-aging dietetic supplement with potential beneficial effects on age-related reproductive decline [ 21 , 22 ]. The present study shows that female mice supplemented with RES over 10 consecutive weeks displayed slightly better reproductive performances compared to not-supplemented sibling controls.…”

The Role of Resveratrol in Human Male Fertility

“…Although many studies have investigated the beneficial effects of RSV on experimental animals, there are few clinical trials in humans on the relationship between this compound and male fertility and the results are often controversial [ 10 ]. A recent review evaluated the impact of RSV on male and female reproduction, by analyzing studies both on human and animal models [ 10 ].…”

“…Although many studies have investigated the beneficial effects of RSV on experimental animals, there are few clinical trials in humans on the relationship between this compound and male fertility and the results are often controversial [ 10 ]. A recent review evaluated the impact of RSV on male and female reproduction, by analyzing studies both on human and animal models [ 10 ]. The authors concluded that, although a considerable amount of research supports the positive impact of RSV on human and animal reproduction, further studies are necessary to consolidate the knowledge on the properties of RSV and its role in reproductive functions.…”