The role of resistin on metabolic syndrome‐induced erectile dysfunction and the possible therapeutic effect of Boldine

Kara, Erkan; Kahraman, Erkan; Dayar, Ezgi; Yetik‐Anacak, Gunay; Demir, Ömer; Gidener, Sedef; Atabey, Neşe; Durmus, Nergiz

doi:10.1111/andr.12853

Cited by 8 publications

(5 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The underlying mechanism may be that the gut ora, with the help of the nervous system, regulates changes in metabolic signal transduction in the body. After insulin resistance occurs, vascular nitric oxide synthesis disorder and insulin-induced vasodilation dysfunction occur one after another, both of which may be the pathogenic factors of male erectile dysfunction [43] . In addition, nitric oxide, as an important substance to regulate penile erection and arose brain sexual desire, its content will also be affected when intestinal ora is dysregulated, and then affect penile erection [44] .…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota and male fertility: a two-sample Mendelian randomization study

Kang,

Wang

2023

Preprint

View full text Add to dashboard Cite

Background Previous studies have reported that alterations in gut microbiota composition are associated with male fertility. However, it is unclear and difficult to establish whether these associations reflect a causal relationship. Objective To reveal the causal association between gut microbiota and male fertility, we conducted a two-sample Mendelian randomization (MR) analysis. Materials and Methods We assessed genome-wide association study (GWAS) summary statistics for gut microbiota and male fertility to perform MR analysis. Independent single nucleotide polymorphisms closely associated with 211 gut bacterial taxa (N = 122110) were identified as instrumental variables. The summary statistic data for male infertility (N = 733,479), abnormal spermatoz (N = 209,921) and erectile dysfunction (N = 223,805) were obtained from the latest release from the FinnGen consortium as the outcome of interest. Two-sample MR was performed to evaluate the causal effect of gut microbiota on male fertility, including inverse-variance-weighted (IVW) method, weighted median method, MR-Egger, mode-based estimation and MR-PRESSO. A series of sensitivity analyses was performed to validate the robustness of the results. The robustness of the estimation was tested by a series of sensitivity analyses including Cochran’s Q test, MR-Egger intercept analysis, leave-one-out analysis and funnel plot were used to assess the causal association. Results Combining the results from the discovery and replication stages, we identified three causal bacterial genus. Ruminiclostridm6 (OR = 0.537, 95%CI = 0.292-0.987, P = 0.045, PFDR = 0.234) was found to be closely associated with male infertility, and the decrease in its quantity increased the risk of male infertility. Decreased Prevotella9 (OR = 0.670, 95%CI = 0.452-0.992, P = 0.046, PFDR = 0.175) was found to be closely related to abnormal sperm. Lachnospiraceae NC2004 group (OR = 1.173, 95%CI = 1.008-1.366, P = 0.078, PFDR = 0.530) was found to be closely related to male erectile dysfunction, and there was a positive correlation between them. No heterogeneity and pleiotropy were detected. Conclusion This study implied a causal relationship between the Ruminiclostridm6 genus, Prevotella9 genus, Lachnospiraceae NC2004 group genus and male fertility, thus providing novel insights into the gut microbiota-mediated development mechanism of ADs. Nevertheless, future studies are warranted to dissect the underlying mechanisms of specific bacterial taxa’s role in the pathophysiology of male fertility.

show abstract

Section: Discussionmentioning

confidence: 99%

Gut microbiota and male fertility: a two-sample Mendelian randomization study

Kang,

Wang

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Nitric Oxide (NO), as an inorganic substance, plays an important role in erectile function through cyclic GMP (cGMP) level changes (Deepak et al., 2021). It was reported that the down‐regulation of eNOS related to the occurrence of ED (Kara et al., 2020). The oxidative damage, caused by oxidative stress and inflammation, would induce the down‐regulation of eNOS and nNOS, further resulting in vascular dysfunction (Daiber et al., 2020).…”

Section: Discussionmentioning

confidence: 99%

Infiltration of inflammatory factors induced penile damage in chronic prostatitis

Wang

Mao

et al. 2021

Andrologia

View full text Add to dashboard Cite

The present study aimed to investigate the mechanism of penile damages in experimental autoimmune prostatitis (EAP) rat models to reveal the potential pathological mechanism of the relationship between CP and penile damages. Sprague–Dawley (SD) rats were administered with different concentrations of prostate tissue homogenate supernatant (PTHS) by multipoint subcutaneous injection to establish EAP models. IHC staining was done to assess the expression of inflammatory cytokines in prostate tissues and the corpus cavernosum of penis. Masson and Tunel staining was conducted to observe the fibrosis and apoptosis in the corpus cavernosum. Finally, the functional changes of corpus cavernosum were assessed by WB and IHC staining. The results revealed that EAP rats with different prostatitis severity were successfully established by PTHS. The expression of IL‐1β, IL‐6 and TNF‐α in prostate tissues increased with the concentration of PTHS. The results of Masson and Tunel staining indicated fibrosis and apoptosis gradually aggravated in corpus cavernosum among different subgroups. The function of cavernosum impaired by prostatitis from WB and IHC results and positively with the severity. In conclusion, there existed the infiltration of inflammatory factors and impaired function in the corpus cavernosum of EAP rats’ penis and positively correlated with the severity of prostatitis.

show abstract

“…Erectile function in penile tissue is mediated with an expression of nitric oxide from endothelial nitric oxide synthase (eNOS). Boldine at a dose of 40 mg/kg/day showed an enhancement in erectile function in metabolic syndrome rat model owing to improvement of eNOS activation in penile tissue and intracavernous pressure/ mean arterial pressure ratio in boldine-treated rats models [55]…”

Section: Erectile Dysfunction Effectmentioning

confidence: 93%

Boldine Alkaloid: Holistic Overview on Potential Health Benefits and Medicinal Merits a comprehensive review

Baky

Abouelela

2022

ERU Research Journal

View full text Add to dashboard Cite

Alkaloids are considered as an important group of phytochemicals that are widely distributed in natural sources. Alkaloids are characterized by their myriad health benefits and medicinal merits being important to human health. Boldine is one of aporphine alkaloid which is widely distributed in several plant species, commonly in boldo tree (Peumus boldus). Boldine alkaloid plays a pivotal role in human health owing to its myriad pharmacological activities. It exhibited several biological activities which posed it for the treatment of several ailments. The current review aims to introduce a holistic highlight on available natural sources, and potential health benefits of boldine and further capitulates on previous pharmacological studies of boldine both in vivo and in vitro . Several databases were searched for a collection of the articles on boldine such as ScienceDirect, PubMed, Springer, Elsevier, Wiley Online Library, Taylor & Francis and EKB. Moreover, the valorization of boldine as a valuable natural compound of important value for the production of pharmaceutical preparations was also addressed.Ultimately, boldine is an extremely important alkaloid with diverse pharmacological actions such as hepatoprotective, antioxidant, anti-inflammatory, and anticancer.

show abstract

The role of resistin on metabolic syndrome‐induced erectile dysfunction and the possible therapeutic effect of Boldine

Cited by 8 publications

References 42 publications

Gut microbiota and male fertility: a two-sample Mendelian randomization study

Gut microbiota and male fertility: a two-sample Mendelian randomization study

Infiltration of inflammatory factors induced penile damage in chronic prostatitis

Boldine Alkaloid: Holistic Overview on Potential Health Benefits and Medicinal Merits a comprehensive review

Contact Info

Product

Resources

About