The Role of Resistin, IL-6 and NH2-Terminal Portion ProBNP in Pathogenesis of Cardiac Disease in Type 2 Diabetes Mellitus

Ghanem, Samar; Torky, Mohamed Hamdy; Gaafar, Ahmed; Mohamed, Somia Mokabel; Eldin, Ghada Mohamed Mohamed Salah; Awad, Samah; Diab, Karema A.; Elsabaawy, Dalia; Yehia, Sania Ali; Abdel‐Samiee, Mohamed; Elshormilisy, Amr Aly

doi:10.2139/ssrn.3521418

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“…Our data are in accordance with several studies showing that resistin plays a major regulatory role in the in ammatory response (48,49). Resistin has also been reported to upregulate the expression of proin ammatory cytokines such as TNF-α, IL-6, IL-12, and monocyte chemoattractant protein in PBMCs, macrophages, and hepatic stellate cells via the nuclear factor-κB pathway (47,50); the correlation of resistin levels with in ammatory and brinolytic markers has been reported both in the general population and in individuals with T2DM, coronary atherosclerosis, chronic kidney disease, rheumatoid arthritis, and/or sepsis (48,49,51).…”

Section: Discussionsupporting

confidence: 93%

Resistin Levels and Inflammatory and Endothelial Dysfunction Markers in Obese Postmenopausal Women With Type 2 Diabetes Mellitus.

Giandalia

Alibrandi

Giorgianni

et al. 2021

Preprint

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Background: Obesity- associated coronary heart disease (CHD) risk is higher in women than in men with type 2 diabetes (T2DM). Resistin, an adipokine secreted by adispose tissue, may contribute to this higher risk.Aims: To explore the relationships among resistin levels and common inflammatory and endothelial dysfunction markers and CHD risk in obese post-menopausal T2DM women.Methods: Serum levels of resistin, hsCRP, IL-6, Soluble vascular cell adhesion molecule (sVCAM), homocysteine (tHcy), HOMA-IR and metabolic parameters were determined in a group of 132 T2DM women with and without documented CHD and in 55 non-diabetic women.Results: Resistin, sVCAM, IL-6 and tHcy levels were comparable in T2DM and controls. CHD women showed higher resistin, sVCAM and tHcy levels than those without CHD, and for resistin this difference remained significant after age-adjustment (P=0.013); conversely hsCRP were ~2X higher in T2DM women than in controls (P=0.0132) without any difference according to CHD history.At univariate analysis resistin levels were significantly associated with age, waist circumference, hypertension, tHcy, hsPCR, sVCAM, IL-6, HDL-cholesterol, triglycerides and creatinine levels, but only creatinine, triglycerides, hsCRP, IL-6 and sVCAM were independent predictors of resistin levels at stepwise regression analysis.Resistin levels were independent predictors of CHD, increasing the risk by 1.15 times (0.986-1.344 95% CI), together with age, tHcy, LDL-C and hypertension. Conclusions: Circulating resistin levels were comparable in obese/overweight T2DM and control women. In T2DM women, resistin levels correlated with markers of renal function, systemic inflammation and endothelial dysfunction and were independently associated with a higher CHD risk.

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