The role of resistin and myeloperoxidase in severe sepsis and septic shock: Results from the ALBIOS trial

Bonaventura, Aldo; Carbone, Federico; Vecchiè, Alessandra; Meessen, Jennifer; Ferraris, Sandra; Beck, Eduardo; Keim, Roberto; Minetti, Silvia; Elia, Edoardo; Ferrara, Daniele; Ansaldo, Anna Maria; Novelli, Deborah; Caironi, Pietro; Latini, Roberto

doi:10.1111/eci.13333

Cited by 18 publications

(19 citation statements)

References 55 publications

(98 reference statements)

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“…Sepsis occurrence and development are often associated with disorders of the fibrinolytic coagulation system; moreover, severe sepsis is closely associated with the occurrence of hemostatic defects and disseminated intravascular coagulation. 22 D-dimer is a degraded product during fibrinolysis. Specifically, D-dimer is formed through fibrinolysin-induced degradation of cross-linked fibrous proteins, with D-dimer levels reflecting the fibrinolysis state of the body.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Susceptibility Characteristics and Risk Factors Associated with Adult Sepsis in Wenzhou, China

Wang

et al. 2022

IDR

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Purpose To clarify the distribution of pathogenic bacteria by analyzing the bacterial susceptibility characteristics and risk factors for adult sepsis in The Wenzhou city, Zhejiang province, China, and to aid early diagnosis, monitoring, and prognosis prediction in cases of bacterial sepsis. Patients and Methods We retrospectively analyzed 329 patients with sepsis admitted to the Second Affiliated Hospital of Wenzhou Medical University between January 2018 and March 2021. Laboratory data were collected before and after treatment; moreover, the bacterial susceptibility characteristics and risk factors for sepsis were comprehensively analyzed using the Sequential Organ Failure Assessment (SOFA) score. Results The SOFA score was negatively correlated with the prognosis (P < 0.05). We isolated 47 pathogenic strains from blood culture samples, including 29 gram-positive strains, 18 gram-negative strains. The most common gram-negative pathogens in blood cultures are Klebsiella pneumoniae and Escherichia coli , while the most common gram-positive pathogens are Staphylococcus aureus and Staphylococcus h omini s . Gram-negative pathogens had resistance rates of 77% and 62.5% to ciprofloxacin and ceftriaxone, respectively. Gram-positive bacteria had a high resistance to penicillin at 100%. Prognostic factors for sepsis included patients’ consciousness, SOFA score, prothrombin time, international normalized ratio, fibrinogen, D-dimer, and aspartate aminotransferase (P < 0.05). Of these, the D-dimer level could predict the outcome of patients with sepsis (AUC = 0.661, P < 0.05). Conclusion The pathogens detected in adult sepsis in Wenzhou are mainly Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus , and Staphylococcus hominis . The pathogens exhibited differences in drug susceptibility. The optimal antibiotics should be chosen based on the principles of rational use and drug susceptibility. Combined with D-dimer levels, these parameters can be used to determine the optimal strategy for preventing and treating pathogenic bacteria.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Susceptibility Characteristics and Risk Factors Associated with Adult Sepsis in Wenzhou, China

Wang

et al. 2022

IDR

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“…High levels of resistin collected on day 1 of ICU admission were associated with an increased likelihood of developing new organ failure, whereas high myeloperoxidase (MPO) levels on day one were associated with an increased risk of developing incident organ failure for clotting and kidney systems [62].…”

Section: Neutrophil-related Biomarkersmentioning

confidence: 99%

Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review

et al. 2022

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A biomarker describes a measurable indicator of a patient's clinical condition that can be measured accurately and reproducibly. Biomarkers offer utility for diagnosis, prognosis, early disease recognition, risk stratification, appropriate treatment (theranostics), and trial enrichment for patients with sepsis or suspected sepsis. In this narrative review, we aim to answer the question, "Do biomarkers in patients with sepsis or septic shock predict mortality, multiple organ dysfunction syndrome (MODS), or organ dysfunction?" We also discuss the role of pro- and anti-inflammatory biomarkers and biomarkers associated with intestinal permeability, endothelial injury, organ dysfunction, blood–brain barrier (BBB) breakdown, brain injury, and short and long-term mortality. For sepsis, a range of biomarkers is identified, including fluid phase pattern recognition molecules (PRMs), complement system, cytokines, chemokines, damage-associated molecular patterns (DAMPs), non-coding RNAs, miRNAs, cell membrane receptors, cell proteins, metabolites, and soluble receptors. We also provide an overview of immune response biomarkers that can help identify or differentiate between systemic inflammatory response syndrome (SIRS), sepsis, septic shock, and sepsis-associated encephalopathy. However, significant work is needed to identify the optimal combinations of biomarkers that can augment diagnosis, treatment, and good patient outcomes.

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“…Several recent studies have uncovered a strong correlation between blood concentrations of resistin and the severity of organ dysfunction in critically ill, septic patients [ 1 – 6 ]. While the physiologic role of human resistin remains unknown, it is thought to be a pro-inflammatory cytokine that triggers TNFα-independent intracellular signaling via the NFκB pathway [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…While the physiologic role of human resistin remains unknown, it is thought to be a pro-inflammatory cytokine that triggers TNFα-independent intracellular signaling via the NFκB pathway [ 7 ]. Some investigators have demonstrated higher circulating resistin concentrations in sepsis non-survivors [ 3 ], whereas others have been unable to confirm this relationship [ 1 , 5 , 6 , 8 ]. Previous studies from our laboratory reported that human resistin impairs neutrophil migration, decreases the production of reactive oxygen species required to kill intracellular and extracellular bacteria, and diminishes the production of neutrophil extracellular traps [ 9 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Resistin production does not affect outcomes in a mouse model of acute surgical sepsis

et al. 2022

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Introduction Because of the strong correlation between the blood concentration of circulating resistin and the illness severity of septic patients, resistin has been proposed as a mediator of sepsis pathophysiology. In vitro data indicate that human resistin directly impairs neutrophil migration and intracellular bacterial killing, although the significance of these findings in vivo remain unclear. Objective The objectives of the present study were: (1) to validate the expression of human resistin in a clinically relevant, murine model of surgical sepsis, (2) to assess how sepsis-induced changes in resistin correlate with markers of infection and organ dysfunction, and (3) to investigate whether the expression of human resistin alters immune function or disease outcomes in vivo. Methods 107 male, C57BL/6 mice transgenic for the human resistin gene and its promoter elements (Retn+/−/−, or Retn+) were generated on a Retn−/− (mouse resistin knockout, or Rko) background. Outcomes were compared between age-matched transgenic and knockout mice. Acute sepsis was defined as the initial 24 h following cecal ligation and puncture (CLP). Physiologic and laboratory parameters correlating to the human Sequential Organ Failure Assessment (SOFA) Score were measured in mice, and innate immune cell number/function in the blood and peritoneal cavity were assessed. Results CLP significantly increased circulating levels of human resistin. The severity of sepsis-induced leukopenia was comparable between Retn+ and Rko mice. Resistin was associated with increased production of neutrophil reactive oxygen species, a decrease in circulating neutrophils at 6 h and an increase in peritoneal Ly6Chi monocytes at 6 h and 24 h post-sepsis. However, intraperitoneal bacterial growth, organ dysfunction and mouse survival did not differ with resistin production in septic mice. Significance Ex vivo resistin-induced impairment of neutrophil function do not appear to translate to increased sepsis severity or poorer outcomes in vivo following CLP.

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The role of resistin and myeloperoxidase in severe sepsis and septic shock: Results from the ALBIOS trial

Cited by 18 publications

References 55 publications

Antimicrobial Susceptibility Characteristics and Risk Factors Associated with Adult Sepsis in Wenzhou, China

Antimicrobial Susceptibility Characteristics and Risk Factors Associated with Adult Sepsis in Wenzhou, China

Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review

Resistin production does not affect outcomes in a mouse model of acute surgical sepsis

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