The Role of Regulatory T Cells in the Development of Autoimmune Process in Multiple Sclerosis

Eliseeva, D. D.; Zavalishin, I. A.; Караулов, Александр Викторович; Быковская, С. Н.

doi:10.15690/vramn.v67i3.188

Cited by 6 publications

(2 citation statements)

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“…Treg cells have been recognized as the critical immunomodulators of the adaptive immune system in MS. Deletion of Treg cells causes spontaneous autoimmune disease in mice, whereas augmentation of Treg-cell function can prevent the development of or attenuate the signs in the experimental autoimmune encephalomyelitis (EAE), the animal model of MS [7]. MS is also associated with impaired maturation of Treg cells [8]. Remission in RRMS has been shown to correspond with increased proportions of FoxP3+ Treg cells in the blood [9].…”

Section: Etiology and Pathology Of Msmentioning

confidence: 99%

Neural Stem Cell-Based Regenerative Approaches for the Treatment of Multiple Sclerosis

et al. 2017

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Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory, and demyelinating disorder of the central nervous system (CNS), which ultimately leads to axonal loss and permanent neurological disability. Current treatments for MS are largely comprised of medications that are either immunomodulatory or immunosuppressive and are aimed at reducing the frequency and intensity of relapses. Neural stem cells (NSCs) in the adult brain can differentiate into oligodendrocytes in a context-specific manner and are shown to be involved in the remyelination in these patients. NSCs may exert their beneficial effects not only through oligodendrocyte replacement but also by providing trophic support and immunomodulation, a phenomenon now known as "therapeutic plasticity." In this review, we first provided an update on the current knowledge regarding MS pathogenesis and the role of immune cells, microglia, and oligodendrocytes in MS disease progression. Next, we reviewed the current progress on research aimed toward stimulating endogenous NSC proliferation and differentiation to oligodendrocytes in vivo and in animal models of demyelination. In addition, we explored the neuroprotective and immunomodulatory effects of transplanted exogenous NSCs on T cell activation, microglial activation, and endogenous remyelination and their effects on the pathological process and prognosis in animal models of MS. Finally, we examined various protocols to generate genetically engineered NSCs as a potential therapy for MS. Overall, this review highlights the studies involving the immunomodulatory, neurotrophic, and regenerative effects of NSCs and novel methods aiming at stimulating the potential of NSCs for the treatment of MS.

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Section: Etiology and Pathology Of Msmentioning

confidence: 99%

Neural Stem Cell-Based Regenerative Approaches for the Treatment of Multiple Sclerosis

et al. 2017

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“…Содержание аскорбиновой кислоты в нем широко варьирует от места произрастания и факторов среды и может достигать 4-14 % [1 -2], но зачастую колеблется в пределах 0,3 -2 % [3 -7]. Витамин С обладает целым рядом полезных свойств: антиоксидантным, противовоспалительным, противосклеротическим, иммуномодулирующим свойствами, способствует синтезу коллагена и т.д.. Также плоды шиповника содержат каротиноиды, витамины группы В, К1, Р, Е, полиненасыщенные жирные кислоты (ПНЖК), пектиновые вещества, органические кислоты (в основном яблочную и лимонную) и полифенолы (дубильные вещества, флавоноиды, катехины), которые обуславливают довольно сильные антиоксидантные свойства препарата [1] и усиливают эффект аскорбиновой кислоты [8]. Кроме того, благодаря наличию органических кислот и флавоноидов шиповник обладает гепатопротекторным и желчегонным действием.…”

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Comparative Characteristics of Preparations Based on Rosehip Fruits

Zotova,

Ryabinina,

Livanova

et al. 2023

APPLIED

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The paper presents a comparative analysis of preparations based on rosehip fruits available on the Russian market in order to determine the effectiveness and expediency of choosing a drug. It is shown that the expediency of choosing a drug should first of all be determined by the purpose of use, despite the fact that all drugs, in addition to specific action, exhibit similar biological activity due to the content of vitamin C and other biologically active substances (BAS), which, depending on the variety of rosehip and the method of preparation of drugs, are still in them in different quantities. For the treatment of skin diseases, it is necessary to choose oils rich in PUFA and vitamin E. For the treatment of liver diseases, you should choose low-vitamin rosehip fruits or syrups based on it, which contain the largest amount of organic acids compared to other drugs. Among the natural preparations of the group of restorative and immunomodulatory effects, the most effective were rosehip fruits and water-soluble dry extract. In addition, it has been experimentally shown that all preparations from this group, except syrups, have adsorption activity against lead ions, which expands the list of useful properties of preparations based on rosehip fruits and increases the effectiveness of their use.

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Th17/Treg immunoregulation and implications in treatment of sulfur mustard gas-induced lung diseases

Iman

Rezaei

Jamalkandi

et al. 2017

Expert Review of Clinical Immunology

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Sulfur mustard (SM) is an extremely toxic gas used in chemical warfare to cause massive lung injury and death. Victims exposed to SM gas acutely present with inhalational lung injury, but among those who survive, some develop obstructive airway diseases referred to as SM-lung syndrome. Pathophysiologically, SM-lung shares many characteristics with smoking-induced chronic obstructive pulmonary disease (COPD), including airway remodeling, goblet cell metaplasia, and obstructive ventilation defect. Some of the hallmarks of COPD pathogenesis, which include dysregulated lung inflammation, neutrophilia, recruitment of interleukin 17A (IL -17A) expressing CD4T cells (Th17), and the paucity of lung regulatory T cells (Tregs), have also been described in SM-lung. Areas covered: A literature search was performed using the MEDLINE, EMBASE, and Web of Science databases inclusive of all literature prior to and including May 2017. Expert commentary: Here we review some of the recent findings that suggest a role for Th17 cell-mediated inflammatory changes associated with pulmonary complications in SM-lung and suggest new therapeutic approaches that could potentially alter disease progression with immune modulating biologics that can restore the lung Th17/Treg balance.

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The Role of Regulatory T Cells in the Development of Autoimmune Process in Multiple Sclerosis

Cited by 6 publications

References 0 publications

Neural Stem Cell-Based Regenerative Approaches for the Treatment of Multiple Sclerosis

Neural Stem Cell-Based Regenerative Approaches for the Treatment of Multiple Sclerosis

Comparative Characteristics of Preparations Based on Rosehip Fruits

Th17/Treg immunoregulation and implications in treatment of sulfur mustard gas-induced lung diseases

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