The Role of Receptor Transactivation in the Cardioprotective Effects of Preconditioning and Postconditioning

Maslov, L. N.; Headrick, John P.; Mechoulam, R.; Lishmanov, A. Yu.; Barzakh, E. I.; Naryzhnaya, N. V.; Zhang, Yi

doi:10.1007/s11055-013-9844-7

Cited by 2 publications

(2 citation statements)

References 54 publications

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“…EGF receptor activation protects against I/R . Met‐enkephalin reduces cell death in isolated cardiomyocytes subjected to hypoxia and reoxygenation and phosphorylates the EGF receptor.…”

Section: Signaling Mechanism Of the Cardioprotective Effect Of Opioidsmentioning

confidence: 99%

Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists

Maslov

Khaliulin

Oeltgen

et al. 2016

Medicinal Research Reviews

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It has now been demonstrated that the μ, δ1, δ2, and κ1 opioid receptor (OR) agonists represent the most promising group of opioids for the creation of drugs enhancing cardiac tolerance to the detrimental effects of ischemia/reperfusion (I/R). Opioids are able to prevent necrosis and apoptosis of cardiomyocytes during I/R and improve cardiac contractility in the reperfusion period. The OR agonists exert an infarct‐reducing effect with prophylactic administration and prevent reperfusion‐induced cardiomyocyte death when ischemic injury of heart has already occurred; that is, opioids can mimic preconditioning and postconditioning phenomena. Furthermore, opioids are also effective in preventing ischemia‐induced arrhythmias.

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“…EGF receptor activation protects against I/R . Met‐enkephalin reduces cell death in isolated cardiomyocytes subjected to hypoxia and reoxygenation and phosphorylates the EGF receptor.…”

Section: Signaling Mechanism Of the Cardioprotective Effect Of Opioidsmentioning

confidence: 99%

Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists

Maslov

Khaliulin

Oeltgen

et al. 2016

Medicinal Research Reviews

View full text Add to dashboard Cite

show abstract

“…34 These data indicate the functional interaction of opioid and adenosine receptors was occurring in these myocytes. 35 Surendra and colleagues concluded that RIP cardioprotection requires the activation of δ-opioid and κ-opioid receptors and relies on these receptors functionally interacting with adenosine receptors. The substance in the dialysate that caused adenosine and opioid receptors to be activated in the Surendra et al study was not identified.…”

Section: Introductionmentioning

confidence: 99%

A Review of Humoral Factors in Remote Preconditioning of the Heart

Tsibulnikov

Маслов

Gorbunov

et al. 2019

J Cardiovasc Pharmacol Ther

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A humoral mechanism of cardioprotection by remote ischemic preconditioning (RIP) has been clearly demonstrated in various models of ischemia–reperfusion including upper and lower extremities, liver, and the mesenteric and renal arteries. A wide range of humoral factors for RIP have been proposed including hydrophobic peptides, opioid peptides, adenosine, prostanoids, endovanilloids, endocannabinoids, calcitonin gene-related peptide, leukotrienes, noradrenaline, adrenomedullin, erythropoietin, apolipoprotein, A-I glucagon-like peptide-1, interleukin 10, stromal cell-derived factor 1, and microRNAs. Virtually, all of the components of ischemic preconditioning’s signaling pathway such as nitric oxide synthase, protein kinase C, redox signaling, PI3-kinase/Akt, glycogen synthase kinase β, ERK1/2, mitoKATP channels, Connexin 43, and STAT were all found to play a role. The signaling pattern also depends on which remote vascular bed was subjected to ischemia and on the time between applying the rip and myocardial ischemia occurs. Because there is convincing evidence for many seemingly diverse humoral components in RIP, the most likely explanation is that the overall mechanism is complex like that seen in ischemic preconditioning where multiple components are both in series and in parallel and interact with each other. Inhibition of any single component in the right circumstance may block the resulting protective effect, and selectively activating that component may trigger the protection. Identifying the humoral factors responsible for RIP might be useful in developing drugs that confer RIP’s protection in a more comfortable and reliable manner.

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The Role of Receptor Transactivation in the Cardioprotective Effects of Preconditioning and Postconditioning

Cited by 2 publications

References 54 publications

Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists

Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists

A Review of Humoral Factors in Remote Preconditioning of the Heart

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