The role of recent nanotechnology in enhancing the efficacy of radiation therapy

Bergs, Judith; Wacker, Matthias G.; Hehlgans, Stephanie; Piiper, Albrecht; Multhoff, Gabriele; Rödel, Claus; Rödel, Franz

doi:10.1016/j.bbcan.2015.06.008

Cited by 47 publications

(36 citation statements)

References 127 publications

(73 reference statements)

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“…Particles with cores of iron oxide or gold shells have already made their way into clinical phase I trials. Bergs et al recently reviewed the existing particle constructs (155). Tumor-specific targeting might be achieved by passive accumulation in the tumor due to the aberrant vasculature with increased leakage and simultaneous impairment of lymphatic drainage (156).…”

Section: Discussionmentioning

confidence: 99%

Integrating Hyperthermia into Modern Radiation Oncology: What Evidence Is Necessary?

2017

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Hyperthermia (HT) is one of the hot topics that have been discussed over decades. However, it never made its way into primetime. The basic biological rationale of heat to enhance the effect of radiation, chemotherapeutic agents, and immunotherapy is evident. Preclinical work has confirmed this effect. HT may trigger changes in perfusion and oxygenation as well as inhibition of DNA repair mechanisms. Moreover, there is evidence for immune stimulation and the induction of systemic immune responses. Despite the increasing number of solid clinical studies, only few centers have included this adjuvant treatment into their repertoire. Over the years, abundant prospective and randomized clinical data have emerged demonstrating a clear benefit of combined HT and radiotherapy for multiple entities such as superficial breast cancer recurrences, cervix carcinoma, or cancers of the head and neck. Regarding less investigated indications, the existing data are promising and more clinical trials are currently recruiting patients. How do we proceed from here? Preclinical evidence is present. Multiple indications benefit from additional HT in the clinical setting. This article summarizes the present evidence and develops ideas for future research.

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Section: Discussionmentioning

confidence: 99%

Integrating Hyperthermia into Modern Radiation Oncology: What Evidence Is Necessary?

2017

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“…[4] In general, RT falls into two categories: external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT). [7][8][9][10][11][12] While EBRT has been extensively employed for treatment of local solid tumors such as breast, colorectal, esophageal, head and neck, lung, prostate, and brain tumors, RIT can be used to treat both local tumors as well as metastatic tumors spread throughout the body. [7] As far as internal RIT in concerned, therapeutic radioisotopes would be introduced into the tumor using minimally invasive procedures such as directly infusion through a catheter (also called brachytherapy), or via suitable tumor-homing carriers (such as antibodies, liposome emulsions or nanoparticles with tumor targeting ligands) through systemic administration.…”

Section: Doi: 101002/adma201700996mentioning

confidence: 99%

“…[4,5] For example, nano materials containing high-Z elements with strong X-ray attenuation ability can act as radio-sensitizing agents, thereby depositing radiation energy within tumors during external RT. [11] In a number of recent studies, nanomaterials can be used to produce hyperthermia triggered by near infrared (NIR) laser or alternating magnetic fields for thermoradiotherapy. [9,25] The combination of nanomedicine-based chemotherapy may also be combined with RT to achieve synergistic anti-tumor therapeutic outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…[9,25] The combination of nanomedicine-based chemotherapy may also be combined with RT to achieve synergistic anti-tumor therapeutic outcomes. [5,6,11] Although the applications of nanomedicine in cancer radio-oncology have already been proposed for over a decade, there have been tremendous new progresses in the past few years, particularly in the development of 'advanced nanomaterials' to promote RT via a number of different innovative mechanisms, which would be the main focus of this review article. [26,27] Interestingly, the microenvironment within solid tumors can be modulated by various nanotechnology strategies to overcome hypoxia-associated radiation resistance and enhance RT efficacy.…”

Section: Introductionmentioning

confidence: 99%

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Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However, owing to the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to tumors. Meanwhile, the RT efficacies are limited by different mechanisms, among which the tumor hypoxia-associated radiation resistance is a well-known one, as there exists hypoxia inside most solid tumors while oxygen is essential to enhance radiation-induced DNA damages. With the development in nanotechnology, there have been great interests in using nanomedicine strategies to enhance radiation responses of tumors. Nanomaterials containing high-Z elements to absorb radiation rays (e.g. X-ray) can act as radio-sensitizers to deposit radiation energy within tumors and promote treatment efficacy. Nanoscale carriers are able to deliver therapeutic radioisotopes into tumors for internal RIT, or chemotherapeutic drugs for synergistically combined chemo-radiotherapy. As uncovered in recent studies, the tumor microenvironment could be modulated by various nanomedicine approaches to overcome hypoxia-associated radiation resistance. Herein, the authors will summarize the applications of nanomedicine for RT cancer treatment, and pay particular attention to the latest development of 'advanced materials' for enhanced cancer RT.

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“…In the medical and pharmaceutical fields, it is applied for detecting tumor cells, delivering nanomedicines through the skin or gastrointestinal tract, enhancing radiation therapy, and extending the pharmacokinetic properties of drugs [2,3,15,20]. In the food industry, nanotechnology is used in agriculture, food processing and packaging, and supplements [13,18].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Extraction of Bioactive Compounds from Bee Pollen by Wet-grinding Technology

Choi¹,

Suh²,

Chung³

2016

Journal of Life Science

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Bee pollen is produced by honeybees and is considered one of the most balanced and nourishing nutritional supplements available. Historically, bee pollen has been prescribed for its healing properties and consumed for its high-energy supply. Recent research has provided evidence that bee pollen has diverse biological activities, such as anti-oxidant, anti-inflammatory, anti-bacterial, and even anti-cancer effects. However, the outer membrane of the pollen grain, exine, is highly resistant to most acidic solutions, high pressure, and even digestive enzymes, and the resulting low bioavailability limits its nutritional and clinical applications. This study applied a wet-grinding method to destroy the exine effectively, and it then examined the pollen's enhanced biological activity. First, microscopic observations provided strong evidence that wet grinding destroyed the exine time-dependently. In addition, the content of polyphenols, well-known ingredients of bee pollen and used as internal standards for the quality control of commercial pollen preparations, increased up to 11-fold with wet grinding. Further, the anti-oxidant activity demonstrated on the ABTS anti-oxidant assay, as well as the DPPH radical scavenging assay, was also dramatically increased. Together, the results presented here support a new technology by which bee pollen can be used as a resource for medical, nutritional, and cosmetic applications.

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The role of recent nanotechnology in enhancing the efficacy of radiation therapy

Cited by 47 publications

References 127 publications

Integrating Hyperthermia into Modern Radiation Oncology: What Evidence Is Necessary?

Integrating Hyperthermia into Modern Radiation Oncology: What Evidence Is Necessary?

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Enhanced Extraction of Bioactive Compounds from Bee Pollen by Wet-grinding Technology

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