The role of reactive oxygen species in the biological activity of antimicrobial agents: An updated mini review

Lam, P. L.; Wong, Raymond Pui On; Lam, Kim Hung; Hung, Ling-Chien; Wong, Megan; Yung, Lai Hang; Ho, Y.-W.; Wong, Wai Yeung; Hau, Desmond Kwok Po; Gambari, Roberto; Chui, Chung‐Hin

doi:10.1016/j.cbi.2020.109023

Cited by 98 publications

(82 citation statements)

References 69 publications

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“…Recently, the antimicrobial activity of antimicrobial peptides has been related to the production of ROS. For example, PMAP-23, a member of the cathelicidin family in pigs, induces a Ca 2+ -dependent NADH oxidation that dramatically increased oxidized NADH levels, suggesting that elevated oxidation was induced by mitochondrial Ca 2+ [ 59 ]. Reduced mitochondrial Ca 2+ levels inhibited NADH oxidation, which is consistent with the assumption that NADH oxidation necessitates the entrance of Ca 2+ ions into the mitochondria.…”

Section: Ros-mediated Activity Of Antimicrobial Peptidesmentioning

confidence: 99%

The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies

Juan

Lastra

Plou

et al. 2021

IJMS

847

521

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Living species are continuously subjected to all extrinsic forms of reactive oxidants and others that are produced endogenously. There is extensive literature on the generation and effects of reactive oxygen species (ROS) in biological processes, both in terms of alteration and their role in cellular signaling and regulatory pathways. Cells produce ROS as a controlled physiological process, but increasing ROS becomes pathological and leads to oxidative stress and disease. The induction of oxidative stress is an imbalance between the production of radical species and the antioxidant defense systems, which can cause damage to cellular biomolecules, including lipids, proteins and DNA. Cellular and biochemical experiments have been complemented in various ways to explain the biological chemistry of ROS oxidants. However, it is often unclear how this translates into chemical reactions involving redox changes. This review addresses this question and includes a robust mechanistic explanation of the chemical reactions of ROS and oxidative stress.

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Section: Ros-mediated Activity Of Antimicrobial Peptidesmentioning

confidence: 99%

The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies

Juan

Lastra

Plou

et al. 2021

IJMS

847

521

View full text Add to dashboard Cite

show abstract

“…H 2 O 2 produces ● OH radicals under UV light irradiation and in combination with metal ions, e.g., Fe 2+ and Cu + ; then, radicals cause disinfection (Nieto-Juarez and Kohn 2020 ; Ueno et al 2020 ). The generated ● OH radicals react highly with proteins, lipids and nucleic acids to result in cleavage of RNA and DNA and destruction of sulfhydryl bonds in proteins and biological membranes (Arjunan et al 2015 ; Lam et al 2020 ).…”

Section: Chemical Disinfectantsmentioning

confidence: 99%

Classical and alternative disinfection strategies to control the COVID-19 virus in healthcare facilities: a review

et al. 2021

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The coronavirus disease COVID-19 has spread throughout the world and has been declared as a pandemic by the World Health Organization on March 11th, 2020. The COVID-19 is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). One possible mode of virus transmission is through surfaces in the healthcare settings. This paper reviews currently used disinfection strategies to control SARS-CoV-2 at the healthcare facilities. Chemical disinfectants include hypochlorite, peroxymonosulfate, alcohols, quaternary ammonium compounds, and hydrogen peroxide. Advanced strategies include no-touch techniques such as engineered antimicrobial surfaces and automated room disinfection systems using hydrogen peroxide vapor or ultraviolet light.

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“…However, some results have contradicted this finding (Keren et al, 2013;Liu and Imlay 2013), leading to significant discourse in the field. While it is beyond the scope of this review, several others have summarized the contribution of ROS to antibiotic lethality (Drlica and Zhao, 2020) (Lam et al, 2020). While ROS toxicity clearly plays a vital role in antibiotic-induced death, the primary target of the antibiotic is the essential trigger initiating the toxic cascade and the primary target may also be the main contributor to toxicity, depending on antibiotic concentration and the conditions encountered by the bacteria.…”

Section: Factors That Dictate Antibiotic Activity In Vitro and In Vivomentioning

confidence: 99%

“…While ROS toxicity clearly plays a vital role in antibiotic-induced death, the primary target of the antibiotic is the essential trigger initiating the toxic cascade and the primary target may also be the main contributor to toxicity, depending on antibiotic concentration and the conditions encountered by the bacteria. For instance, at high concentrations, beta-lactam antibiotics can kill by inducing cellular rupture or at lower drug concentrations by a combination of cell-wall damage, futile cycles, and ROS generation (Cho et al, 2014;Lam et al, 2020). It is thus likely that the contribution of ROS to toxicity is dependent on the metabolic environment and respiratory capacity of the bacteria.…”

Section: Factors That Dictate Antibiotic Activity In Vitro and In Vivomentioning

confidence: 99%

Oxygen and Metabolism: Digesting Determinants of Antibiotic Susceptibility in the Gut

et al. 2020

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Summary Microbial metabolism is a major determinant of antibiotic susceptibility. Environmental conditions that modify metabolism, notably oxygen availability and redox potential, can directly fine-tune susceptibility to antibiotics. Despite this, relatively few studies have discussed these modifications within the gastrointestinal tract and their implication on in vivo drug activity and the off-target effects of antibiotics in the gut. In this review, we discuss the environmental and biogeographical complexity of the gastrointestinal tract in regard to oxygen availability and redox potential, addressing how the heterogeneity of gut microhabitats may modify antibiotic activity in vivo . We contextualize the current literature surrounding oxygen availability and antibiotic efficacy and discuss empirical treatments. We end by discussing predicted patterns of antibiotic activity in prominent microbiome taxa, given gut heterogeneity, oxygen availability, and polymicrobial interactions. We also propose additional work required to fully elucidate the role of oxygen metabolism on antibiotic susceptibility in the context of the gut.

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The role of reactive oxygen species in the biological activity of antimicrobial agents: An updated mini review

Cited by 98 publications

References 69 publications

The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies

The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies

Classical and alternative disinfection strategies to control the COVID-19 virus in healthcare facilities: a review

Oxygen and Metabolism: Digesting Determinants of Antibiotic Susceptibility in the Gut

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