The role of reactive oxygen species in the genotoxicity of surface-modified magnetite nanoparticles

Mesárošová, Monika; Kozics, Katarína; Bábelová, Andrea; Regendová, Eva; Pastorek, Michal; Vnuková, Dominika; Buliaková, Barbora; Rázga, Filip; Gábelová, Alena

doi:10.1016/j.toxlet.2014.02.025

Cited by 50 publications

(25 citation statements)

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“…Exposure to FeNPs can alter cell morphology, cytoskeleton of cells, and cell motility (23). Genotoxic effects of FeNPs are mainly influenced by direct interaction with leached iron ions from FeNPs or various indirect factors, such as excessive production of ROS (24). However, information concerning FeNP-related skin toxicity is scant, as is information on the effects of AlNPs and AgNPs on skin corrosion and skin irritation.…”

Section: Discussionmentioning

confidence: 99%

Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDerm^TM

et al. 2016

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Effects of nanoparticles (NPs) on skin corrosion and irritation using three-dimensional human skin models were investigated based on the test guidelines of Organization for Economic Co-operation and Development (OECD TG431 and TG439). EpiDermTM skin was incubated with NPs including those harboring iron (FeNPs), aluminum oxide (AlNPs), titanium oxide (TNPs), and silver (AgNPs) for a defined time according to the test guidelines. Cell viabilities of EpiDermTM skins were measured by the 3-(4, 5-dimethylthi-azol-2-yl)-2.5-diphenyltetrazolium bromide based method. FeNPs, AlNPs, TNPs, and AgNPs were non-corrosive because the viability was more than 50% after 3 min exposure and more than 15% after 60 min exposure, which are the non-corrosive criteria. All NPs were also non-irritants, based on viability exceeding 50% after 60 min exposure and 42 hr post-incubation. Release of interleukin 1-alpha and histopathological analysis supported the cell viability results. These findings suggest that FeNPs, AlNPs, TNPs, and AgNPs are ‘non-corrosive’ and ‘non-irritant’ to human skin by a globally harmonized classification system.

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Section: Discussionmentioning

confidence: 99%

Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDerm^TM

et al. 2016

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“…The induction of oxidative stress in a cell is a direct result of iron oxide internalization [58]. The high oxidative stress induced by PMag due to the magnetite core could activate the molecular machinery that limits potential damage from an oxidative burst.…”

Section: Discussionmentioning

confidence: 99%

Polyethylenimine-coated SPION exhibits potential intrinsic anti-metastatic properties inhibiting migration and invasion of pancreatic tumor cells

Mulens-Arias

Rojas

Pérez-Yagüe

et al. 2015

Journal of Controlled Release

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“…The results allowed for the conclusion that ROS formation plays an important role in the genotoxicity of magnetite in lung cells. On the other hand, magnetite nanoparticles might be considerably less toxic when surface-modified (i.e., coated) (19).…”

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confidence: 99%

Magnetite in the human body: Biogenic vs. anthropogenic

Gieré

2016

Proc. Natl. Acad. Sci. U.S.A.

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The role of reactive oxygen species in the genotoxicity of surface-modified magnetite nanoparticles

Cited by 50 publications

References 56 publications

Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDerm^TM

Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDerm^TM

Polyethylenimine-coated SPION exhibits potential intrinsic anti-metastatic properties inhibiting migration and invasion of pancreatic tumor cells

Magnetite in the human body: Biogenic vs. anthropogenic

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The role of reactive oxygen species in the genotoxicity of surface-modified magnetite nanoparticles

Cited by 50 publications

References 56 publications

Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDermTM

Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDermTM

Polyethylenimine-coated SPION exhibits potential intrinsic anti-metastatic properties inhibiting migration and invasion of pancreatic tumor cells

Magnetite in the human body: Biogenic vs. anthropogenic

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Product

Resources

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Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDerm^TM

Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDerm^TM