The role of rare earth elements in bone tissue engineering scaffolds - A review

Systematic in vitro and in vivo study on biodegradable binary Zn-0.2 at% Rare Earth alloys (Zn-RE: Sc, Y, La–Nd, Sm–Lu)

“…The electrochemical measurements on the Zn and Zn-RE alloys also exhibit both increased and decreased corrosion rates with different REEs in SBF and the trend is difficult to conclude. All the REEs possess higher electrochemical potential from −1.991 V to −2.379 V than that of Zn at −0.76 V, suggesting the REEs alloyed in Zn could slow down the degradation rate because Zn-RE alloys are relatively easy to react with environments to degrade and the resulted oxides layers could passivate and prevent further corrosion process [ 53 ]. However, it is commonly found the corrosion rates of Zn alloys, Zn-x(Mg, Ca, Sr, Li, Mn, Fe, Cu or Ag, 0.1–0.8 wt%) [ 27 ], were all enhanced regardless of the electrochemical potential differences.…”

“…As much as we are aware, the effect of REEs in the biodegradable Zn was comprehensively studied for the first time in this work. To fully understand the role of REEs in biodegradable metals [ 53 ], we compared the Zn-RE alloys system and Mg-RE alloys system from the design principles of biodegradable metallic alloys for biomedical implants [ 73 ] from the following aspects, alloying concentration, microstructure, mechanical properties, degradation properties, and in vivo and in vitro biocompatibility. The comparison results are summarized in Fig.…”

Trends in the Development of Hydroxyapatite From Natural Sources for Biomedical Applications

“…The incidence of these trace elements is however critical for biodegradation and bio-resorption during bioactive interactions, which then leads to total bone restoration in the patient. For example, there have been instances of improved activity per osteogenesis and bio-resorption in bone restoration using rare-earth metals doped HAp [32]. Reports and reviews from Obada et al [17] and Pu'ad et al [33] reported that bone regeneration and formation processes were accelerated by the inclusion of trace elements in HAp.…”

Improvement in the healing of bone fractures using a cyclodextrin/Ni-MOF nanofibers network: the development of a novel substrate to increase the surface area with desirable functional properties

“…Thus, the porous and fibrillar architecture enables the ECM to improve cell function, especially adhesion, migration, and proliferation. 2–4…”