The role of randomization inference in unraveling individual treatment effects in early phase vaccine trials
Zhe Chen,
Xinran Li,
Bo Zhang
Abstract:Randomization inference is a powerful tool in early phase vaccine trials when estimating the causal effect of a regimen against a placebo or another regimen. Randomization-based inference often focuses on testing either Fisher’s sharp null hypothesis of no treatment effect for any participant or Neyman’s weak null hypothesis of no sample average treatment effect. Many recent efforts have explored conducting exact randomization-based inference for other summaries of the treatment effect profile, for instance, q… Show more
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