The role of radiotherapy in the management of operable locally advanced breast carcinoma

Olson, John E.; Neuberg, Donna; Pandya, Kishan J.; Richter, Mandy; Solin, Lawrence J.; Gilchrist, Kennedy W.; Tormey, Douglass C.; Veeder, Michael H.; Falkson, Geoffrey

doi:10.1002/(sici)1097-0142(19970315)79:6<1138::aid-cncr12>3.3.co;2-b

Cited by 12 publications

(13 citation statements)

References 8 publications

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“…In the largest study evaluating locoregional therapy, 59,60 eligible patients with operable LABC had a mastectomy, 6 cycles of anthracycline-based chemotherapy and, if disease-free, were randomly assigned to receive radiotherapy or observation with radiotherapy at isolated sites of locoregional failure (Table 2). Locoregional recurrences were reduced from 24% to 15% with immediate radiotherapy (level I evidence).…”

Section: Locoregional Managementmentioning

confidence: 99%

Clinical practice guidelines for the care and treatment of breast cancer: 15. Treatment for women with stage III or locally advanced breast cancer

Shenkier

Weir²,

Levine³

et al. 2004

Canadian Medical Association Journal

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Section: Locoregional Managementmentioning

confidence: 99%

Clinical practice guidelines for the care and treatment of breast cancer: 15. Treatment for women with stage III or locally advanced breast cancer

Shenkier

Weir²,

Levine³

et al. 2004

Canadian Medical Association Journal

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“…A survival benefit was seen in both studies with a median follow-up of 10 years. A third study, done by the Eastern Cooperative Oncology Group, examined the addition of RT to mastectomy and 6 months of CAFTH (cyclophosphamide, doxorubicin, 5-fluorouracil, tamoxifen, and aminoglutethimide) chemotherapy in 332 patients with T4N0-2, T3N1-2, and T1-2N2 disease [17]. In that study, patients treated with RT had a better local control with worse short-term systemic control, but similar overall survival.…”

Section: Adding Rt To Surgery and Systemic Therapy In Operable Labcmentioning

confidence: 99%

Preoperative Therapy in Breast Cancer: Lessons from the Treatment of Locally Advanced Disease

Wolff

Davidson

2002

The Oncologist

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The greater use of screening has changed the stage distribution of breast cancer, and an increasing number of patients are diagnosed with earlier stages of the disease. Still, locally advanced breast cancer (LABC) remains a major clinical problem in the United States and a common presentation in many parts of the world. There is no standard definition of LABC. One commonly used includes patients with large primary tumors greater than 5 cm (T3) or with skin/chest wall involvement (T4), and/or fixed axillary (N2) or ipsilateral internal mammary (N3) lymph node involvement. According to the tumor node metastasis staging, these usually include stage IIIa (T0-2N2 or T3N1-2) and stage IIIb (T4Nx or TxN3) disease. Inflammatory breast cancer (T4d) is included in most classifications despite its distinct clinical behavior and worse prognosis overall, but it serves as an example of combined modality intervention. Historically, the term LABC has been applied to those clinical presentations where the disease is considered inoperable. However, these therapeutic principles (including preoperative or primary systemic therapy [PST]) are increasingly being applied to patients presenting with tumors greater than 5 cm and negative lymph nodes (stage IIb-T3N0) or even smaller tumors, who are considered to have operable disease and a better outcome than those traditionally classified as having LABC. PST is increasingly being used in otherwise operable stage I and II patients aiming at greater rates of breast conservation and earlier efficacy assessment. This article reviews many of these issues and ongoing research questions. The Oncologist 2002;7:239-245 The Oncologist 2002;7:239-245 www.TheOncologist.comCorrespondence: Antonio C. Wolff, M.D., The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting-Blaustein Cancer Research Building, Room 189, 1650 Orleans Street, Baltimore, Maryland 21231-1000 Fax: 410-955-0125; e-mail: awolff@jhmi.edu Received December 21, 2001; accepted for publication February 4, 2002. ©AlphaMed Press 1083-7159/2002 The Oncologist ® Mayo Clinic Hematology/Oncology Reviews LEARNING OBJECTIVESAfter completing this course, the reader will be able to:1. Better understand the current state of the art of managing patients with locally advanced breast cancer.2. Understand how primary, preoperative systemic treatment might be incorporated into the management of patients with early stage breast cancer.3. Understand the status of ongoing and recently completed clinical trials in this important area of multi-modality patient care.Access and take the CME test online and receive one hour of AMA PRA category 1 credit at CME.TheOncologist.com CME CME

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“…19 The majority of the trials included pre-and postmenopausal women with node-positive disease who underwent modified radical mastectomy. [5][6][7][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] The adjuvant chemotherapy regimen most commonly used was cyclophosphamide, methotrexate and fluorouracil (CMF). The median duration of follow-up was 7.5-14.5 years.…”

Section: Evidence For Post-mastectomy Radiotherapymentioning

confidence: 99%

Clinical practice guidelines for the care and treatment of breast cancer: 16. Locoregional post-mastectomy radiotherapy

Truong

Olivotto²,

Whelan³

et al. 2004

Canadian Medical Association Journal

162

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The role of radiotherapy in the management of operable locally advanced breast carcinoma

Cited by 12 publications

References 8 publications

Clinical practice guidelines for the care and treatment of breast cancer: 15. Treatment for women with stage III or locally advanced breast cancer

Clinical practice guidelines for the care and treatment of breast cancer: 15. Treatment for women with stage III or locally advanced breast cancer

Preoperative Therapy in Breast Cancer: Lessons from the Treatment of Locally Advanced Disease

Clinical practice guidelines for the care and treatment of breast cancer: 16. Locoregional post-mastectomy radiotherapy

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