The role of radiotherapy for patients with adenoid cystic carcinoma of the salivary gland

Umeda, Masahiro; Nishimatsu, Naruki; Yokoo, Satoshi; Shibuya, Yasuyuki; Fujioka, Manabu; Komori, Takahide

doi:10.1067/moe.2000.106302

Cited by 23 publications

(9 citation statements)

References 14 publications

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“…According to the literature, adjuvant radiotherapy is indicated in cases of high grade malignancies, in cases of close or positive margins, in cases of lymphatic spread to the neck and in cases of advanced and recurrent tumor disease. A primary radiotherapy without surgery is only indicated in cases of inoperable tumor disease or in cases with extensive metastatic disease, both with palliative intent 1,3,16,22,30,46 . If possible, a dose of at least 60 Gy should be applied.…”

Section: Discussionmentioning

confidence: 99%

Epithelial malignancies of the salivary glands: clinical experience of a single institution—a review

Kokemueller

Swennen

Brueggemann

et al. 2004

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Epithelial malignancies of the salivary glands: clinical experience of a single institution—a review

Kokemueller

Swennen

Brueggemann

et al. 2004

International Journal of Oral and Maxillofacial Surgery

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“…The median duration from onset of symptoms to diagnosis was 12 months (range, 0-248 months). The main symptoms at presentation were facial numbness or pain in 35% (8) of the patients, vision change in 22% (5), nasal congestion or obstruction in 43% (10), headache in 29% (6), cranial nerve deficits in 48% (11), and dental problems in 29% (6). None of the patients had received previous irradiation to the primary site.…”

Section: Patient and Tumor Characteristicsmentioning

confidence: 99%

“…The base of the skull was involved in all patients. Tumor involved the orbital soft tissues in 39% (9) of the patients, sphenoid sinus in 61% (14), frontal sinus in 17% (4), nasopharynx in 61% (14), clivus in 48% (11), pterygopalatine fossa in 78% (18), infratemporal fossa in 39% (9), cavernous sinus in 74% (17), Meckel's cave in 57% (13), and brain parenchyma in 52% (n=12). All but 3 patients had gross tumor prior to the initiation of radiation.…”

Section: Patient and Tumor Characteristicsmentioning

confidence: 99%

“…[2][3][4][5][6][7][8][9][10][11][12][13] Patients with inoperable tumors or gross residual disease have the worst outcomes, with local control rates of 0% to 30%. 2,4,[10][11][12][13][14] Alternative treatment strategies are clearly needed for adenoid cystic carcinoma with skull base involvement. Although it has been shown that an increased radiation dose is associated with improved local control, 8,12,15 the surrounding critical healthy tissues in the skull base precludes the delivery of adequate tumoricidal dose.…”

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confidence: 99%

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Proton Beam Radiation Therapy for Skull Base Adenoid Cystic Carcinoma

Pommier¹,

Liebsch²,

Deschler³

et al. 2006

Arch Otolaryngol Head Neck Surg

202

142

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Objective:To determine the treatment outcome and prognostic factors in patients with adenoid cystic carcinoma of the skull base treated with proton beam radiation therapy.Design: Retrospective analysis.Setting: Massachusetts General Hospital, Massachusetts Eye and Ear Infirmary, and Harvard Medical School, Boston.Patients: From 1991 to 2002, 23 patients with newly diagnosed adenoid cystic carcinoma with skull base extension were treated with combined proton and photon radiotherapy. There was tumor involvement of the sphenoid sinus in 61% of patients (14), nasopharynx in 61% (14), clivus in 48% (11), and cavernous sinus in 74% (17). The extent of surgery was biopsy alone in 48% (11), partial resection in 39% (9), and gross total resection with positive margins in 13% (3). The median total dose to the primary site was 75.9 cobalt-gray equivalent. The median follow-up of all surviving patients was 64 months. Main Outcome Measures:Locoregional control and disease-free survival and overall survival rates.Results: Tumors recurred locally in 2 patients at 33 and 68 months, respectively. No patients developed neck recurrence. Eight patients had distant metastasis as the first site of recurrence. The local control rate at 5 years was 93%. The rate of freedom from distant metastasis at 5 years was 62%. The disease-free and overall survival rates at 5 years were 56% and 77%, respectively. In multivariate analysis, significant adverse factors predictive for overall survival were change in vision at presentation (P=.02) and involvement of sphenoid sinus and clivus (P=.01). Conclusions:High-dose conformal proton beam radiation therapy results in a very encouraging local control rate in patients with adenoid cystic carcinoma of the skull base. Changes in vision at presentation and tumor involvement of the sphenoid sinus and clivus are important prognostic factors.

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“…On few occasions there is frequently unrecognized perineural invasion in specimens with ''negative'' margins that would have benefited from the addition of radiation therapy. 16 The use of fast neutron irradiation seems to be better than photon beam therapy because of the higher relative biologic effectiveness of neutron radiation. 17 Chemotherapy currently is seeking a role in the management of advanced and metastatic salivary gland tumors.…”

Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma of the floor of the mouth – A rare presentation

Jaiswara

Dhiman

Singh

et al. 2016

Journal of Oral Biology and Craniofacial Research

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Adenoid cystic carcinoma (ACC) is an unusual salivary gland malignancy that remains poorly understood. It is a slow growing but aggressive neoplasm with a tendency for recurrence. It is characterized by the proliferation of ductal (luminal) and myoepithelial cells in cribriform, tubular, solid, and cystic forms. Standard treatment, including surgery with postoperative radiation therapy, has attained reasonable local control rates, but distant metastases do not allow any improvement in the survival rate. The understanding of the molecular mechanisms driving ACC is quite rudimentary. We present a case of a 55-year-old female diagnosed with ACC involving the floor of the mouth with an aim to present the carcinoma's behavior, immunohistocytochemistry, the staining pattern, its treatment, and prognosis.

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The role of radiotherapy for patients with adenoid cystic carcinoma of the salivary gland

Cited by 23 publications

References 14 publications

Epithelial malignancies of the salivary glands: clinical experience of a single institution—a review

Epithelial malignancies of the salivary glands: clinical experience of a single institution—a review

Proton Beam Radiation Therapy for Skull Base Adenoid Cystic Carcinoma

Adenoid cystic carcinoma of the floor of the mouth – A rare presentation

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