The Role of Radionuclide Bone Scintigraphy in Fibrous Dysplasia of Bone

Ye, Zhibin; Luo, Quan‐Yong; Chen, Libo; Zhu, Jia; Lu, Hankui; Zhu, Jun; Zhu, Ran

doi:10.1097/01.rlu.0000113856.77103.7e

Cited by 53 publications

(30 citation statements)

References 9 publications

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“…Bunların yanında tüm vucut kemik sintigrafisi ile hastalığın yaygınlığı saptanabilir. Kemik sintigrafisinin sensitivitesi yüksek olmasına rağmen aktivite artışı fibröz displazi için spesifik değildir [6]. Bizim vakalarımızda radyolojik tetkikler ile toraks duvarındaki lezyon tespit edildi, üç boyutlu kemik tomografisi çektirildi ve cerrahi planlandığı için her iki hastaya da kemik sintigrafisi çektirildi, sadece lezyonun olduğu bölgelerde tutulum gözlendi.…”

Section: Discussionunclassified

Monostotic Fibrous Dysplasia (Two Cases Report)

Döngel¹

2012

Ann Clin Anal Med

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ÖzetFibröz displazi kemiğin mezenkimal kökenli, normal kemiğin yapıca zayıf fibröz ve osseöz doku ile yer değiştirmesi sonucu oluşan lokalize iyi huylu gelişimsel bir anomalisidir. Etiyolojisi tam olarak bilinmemektedir. Üç formu tanımlanmıştır, monostotik fibröz displazi en çok görülen form olup olguların %70' ini oluşturur, ço-ğunlukla ergenlik döneminde görülür ve kemik büyümesinin durması ile sakinleşir. Endokrin hastalıklarla birliktelik gösteren çok odaklı fibröz displazi en az görülen form olup olguların % 3-5'inin oluşturur. Kliniğimizde kemik gelişimini tamamlamış, göğüs ağrısı şikayetleri ile başvuran ve izole tek kotta monostotik fibröz displazi tanısı konulan, tanı ve tedavi amaçlı cerrahi olarak enbloc kot rezeksiyonu uygulanan iki hastayı literatür bilgileri eşliğinde sunmayı amaçladık. Anahtar Kelimeler Fibröz Displazi; Monostotik; Poliostotik; Enbloc Rezeksiyon AbstractFibrous dysplasia is an a developmental benign anomaly of the bone which originates mesenchymal cells. It has an unknown origin. Three types were defined.Monostotic fibrous dysplasia is the most frequent form approximately 70% of all cases. It's seen in adoscelent ages and calms down when the bone growth ends.Multifocal fibrous dysplasia which is seen with endocrine diseases are about of 3-5% of all cases. In this study we aimed to present two cases of monostotic fibrous dysplasia after completion bone growth. We performed enbloc resection of the rib for the purpose of diagnosis and treatment.

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Section: Discussionunclassified

Monostotic Fibrous Dysplasia (Two Cases Report)

Döngel¹

2012

Ann Clin Anal Med

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“…Histopathologic examination of the T2-hyperintense cases revealed fewer bony trabeculae, less cellularity and fewer collagen fibers than that of the T2-hypointense cases (10). FD usually shows increased uptake on radioscintigraphy, but less frequently FD shows no uptake (11). CT is still the best technique for demonstrating the typical radiographic descriptions of FD, which are the "ground-glass" pattern of the bone and the lesion being surrounded by a distinct rim of reactive bone (1).…”

Section: Discussionmentioning

confidence: 99%

F-18 FDG PET-positive Fibrous Dysplasia in a Patient with Intestinal Non-Hodgkin's Lymphoma

Kim

et al. 2009

Cancer Res Treat

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“…In computed tomography (CT) the lesions have a typical ground-glass appearance on the images, showing varying degrees of opacity depending on the ratio of the fibrous and osseous components as well as bone expansion and sclerosis at the margins [1][2][3]. In bone scintigraphy with 99m Tc-labelled methylene diphosphonate ( 99m Tc-MDP) the lesions of fibrous dysplasia regularly show a markedly increased radiotracer uptake and, therefore, can often not be distinguished from a malignant tumour [4][5][6][7][8]. To our knowledge, no systematic studies have been published to date that assess glucose uptake with positron emission tomography (PET) and the radioactively labelled glucose derivative 18 F-fluoro-deoxyglucose (FDG) in fibrous dysplasia.…”

Section: Positron Emission Tomographymentioning

confidence: 99%

Unexpected finding of elevated glucose uptake in fibrous dysplasia mimicking malignancy: contradicting metabolism and morphology in combined PET/CT

et al. 2006

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Fibrous dysplasia is a common benign disorder of bone in which fibro-osseous tissue replaces bone spongiosa. Lesions have a typical appearance on computed tomography (CT) images and regularly show a markedly increased uptake in bone scintigraphy using (99m)Tc-labelled methylene diphosphonate ((99m)Tc-MDP) as radiotracer. The glucose avidity of these lesions depicted by positron emission tomography (PET) using the radiolabelled glucose derivative (18)F-fluoro-2-deoxy-glucose (FDG) is less well known since FDG-PET does not have a role in the assessment of this disease. However, single cases have been reported in which fibrous dysplasia was present in patients undergoing FDG-PET scanning for oncological reasons, and no significant FDG uptake was observed for lesions identified as fibrous dysplasia. We report on a 24-year-old man with known fibrous dysplasia who underwent combined FDG-PET/CT scanning because of suspected recurrence of testicular cancer. In contrast to prior reports, a markedly elevated uptake of FDG was seen in numerous locations that were identified as fibrous dysplasia by CT. Based on this result, we conclude that fibrous dysplasia may mimick malignancy in FDG-PET and that coregistered CT may help to resolve these equivocal findings.

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The Role of Radionuclide Bone Scintigraphy in Fibrous Dysplasia of Bone

Abstract: Radionuclide bone scans are of certain value in the diagnosis of FD. The diagnostic specificity of FD with radionuclide bone scanning can be improved in association with other imaging modalities such as x-rays.

Cited by 53 publications

References 9 publications

Monostotic Fibrous Dysplasia (Two Cases Report)

Monostotic Fibrous Dysplasia (Two Cases Report)

F-18 FDG PET-positive Fibrous Dysplasia in a Patient with Intestinal Non-Hodgkin's Lymphoma

Unexpected finding of elevated glucose uptake in fibrous dysplasia mimicking malignancy: contradicting metabolism and morphology in combined PET/CT

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