The Role of Radiation Therapy in Malignant Lymphomas, Including Hodgkin’s Disease

Zagars, Gunar K.; Rubin, Philip

doi:10.1007/978-94-009-8279-6_4

Cited by 4 publications

(1 citation statement)

References 221 publications

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“…This series achieved a 5-year survival for stage IE and HE patients of 79 per cent and 36 per cent respectively (p<0-05). These compare to published survivals of 50-86 per cent for stage IE and 27-41 per cent for stage HE (Barton et al, 1984;Shimm et al, 1984;Fujitani etai, 1984;Zagars and Rubin, 1981;Terz and Farr, 1969;Hoppe et al, 1978). In stages IE and HE, Shimm etal.…”

Section: Discussionsupporting

confidence: 68%

Non-hodgkin's lymphoma of the tonsil

1987

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Over the 27-year period from 1954-1981, 51 patients with non-Hodgkin's lymphoma arising in the tonsil were treated at the Regional Radiotherapy Centre, Mount Vernon Hospital. The original biopsy material was reviewed in each case and reclassified using the British National Lymphoma Investigation criteria. Grade 2 non-Hodgkin's lymphoma was reported in 80 per cent of cases. Ninety per cent of patients presented in stages IE or IIE and were treated with radical local radiotherapy. A 5-year survival of 51 per cent was achieved and a 5-year relapse-free survival of 35 per cent. Stage IE patients had a statistically significant survival advantage compared to stage IIE. Sixty-one per cent of patients relapsed, of whom 74 per cent died from active lymphoma. The abdomen was the most frequent site for relapse with involvement of both nodal and extranodal sites.

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Section: Discussionsupporting

confidence: 68%

Non-hodgkin's lymphoma of the tonsil

1987

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Primary Chemotherapy for Localized Non-Hodgkin's Lymphomas With Diffuse Histologic Characteristics

et al. 1986

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Laparotomy-stagedIA versusIIA Hodgkin's disease. A comparative study with evaluation of prognostic factors for stageIIA disease

Zagars

Rubin

1985

Cancer

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Ninety-one laparotomy-staged (LAP) IA and IIA Hodgkin's disease (HD) patients were analyzed to evaluate the prognostic significance of stage, mediastinal status, extranodal disease and histology. Forty IA patients were treated with radiotherapy (XRT) only; of 51 IIA patients, 44 received XRT only and 7 had additional chemotherapy. Disease-free survival (DFS) at 5 and 10 years was 81% and 70%, respectively, with overall survival (S) of 93% and 86%, respectively. Disease-free survival for IA patients (93% at 5 and 10 years) was significantly superior to IIA (73% at 5 years, 52% at 10 years). Survival differences were not statistically significant. For IIA patients receiving XRT only, large mediastinal disease was an adverse factor for DFS. Small mediastinal disease in IIA was significantly better than no mediastinal disease. For the whole group of LAP IA and IIA treated by XRT only, three prognostic groups were identified: (1) Stage IA and Stage IIA with mediastinal disease, but less than 7.5 cm in width was highly favorable with less than 10% relapse; (2) Stage IIA nonmediastinal had an intermediate prognosis with relapse in about 33%; (3) Stage IIA large mediastinal (greater than or equal to 7.5 cm) had an unfavorable DFS with relapse in about 55%. The third group contained a highly unfavorable subset with mediastinal masses greater than 10 cm, all of whom relapsed. Salvage therapy was successful in 60% of relapsing patients. In the context of relatively effective salvage therapy, the role of adjuvant chemotherapy in adverse prognostic groups is discussed and it is concluded that the only clearly justifiable use for adjuvant chemotherapy is in patients with massive (greater than 10 cm) mediastinal adenopathy.

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The Role of Radiation Therapy in Malignant Lymphomas, Including Hodgkin’s Disease

Cited by 4 publications

References 221 publications

Non-hodgkin's lymphoma of the tonsil

Non-hodgkin's lymphoma of the tonsil

Primary Chemotherapy for Localized Non-Hodgkin's Lymphomas With Diffuse Histologic Characteristics

Laparotomy-stagedIA versusIIA Hodgkin's disease. A comparative study with evaluation of prognostic factors for stageIIA disease

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