The role of radiation therapy in carcinoma of the extrahepatic bile ducts

Fogel, Thomas D.; Weissberg, Joseph B.

doi:10.1016/0360-3016(84)90230-x

Cited by 35 publications

(8 citation statements)

References 35 publications

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“…Additional areas of investigation include the use of hyperthermia in association with intraluminal iridium, extensive liver resection, liver transplantation, and whole liver irradiation [58][59][60] as well as the role of chemotherapy [1,2,4,5,7,8,10,14,15,17,22,24,29,[34][35][36]43,45,50].…”

Section: Discussionmentioning

confidence: 99%

“…Intraluminal brachytherapy (radiation delivered through the lumens of the bile ducts) may provide this option, providing access and additional dose delivery to the tumor while sparing the surrounding normal tissues [3,7,8,. EBRT usually precedes brachytherapy [8,15,16,19,20,[22][23][24]29,30,32,34,36,[39][40][41]43] to decrease tumor bulk before implantation so that residual disease is encompassed by the limited range of the intraluminal radiation. At some institutions, implantation has preceded EBRT [3,[10][11][12][13][14][16][17][18][19]33,[37][38].…”

Section: Definite External Beam Radiation Therapy (Ebrt) and Brachythmentioning

confidence: 99%

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Review article: Biliary tree malignancies

Erickson

Nag

1998

J. Surg. Oncol.

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Radiation therapy is used as definitive treatment for unresectable bile duct tumors, or as adjuvant therapy after resection. External beam irradiation of 45–50 Gy is generally given whenever feasible. Intraluminal brachytherapy is a useful technique to deliver higher doses of radiation to the tumor while respecting the tolerance of the surrounding normal tissues. Brachytherapy can be given at a high dose rate or low dose rate via an in‐dwelling biliary drainage catheter to boost external beam doses. Brachytherapy alone is reserved for palliative therapy. Techniques should be implemented with care to make them not only effective but safe. The long‐term efficacy and morbidity of this mode of radiation should be studied further. Only large prospective trials can lead to resolution of some of the questions yet unsolved in treatment of these challenging malignancies. J. Surg. Oncol. 1998;67:203–210. © 1998 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Definite External Beam Radiation Therapy (Ebrt) and Brachythmentioning

confidence: 99%

Review article: Biliary tree malignancies

Erickson

Nag

1998

J. Surg. Oncol.

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“…Patients should be fit enough (WHO score 0-2) for the procedure, and should have been reviewed to confirm that they are not suitable for resection. Combined treatment is possible in patients who are in reasonably good condition; it is usual to combine BT with EBRT [9, 21, 22, 23, 24, 25, 26, 27, 28]. Although the results available in the literature are somewhat contradictory with regard to the possible use of BT in a curative setting, some evidence indicates that BT can improve results of the treatment of unresectable extrahepatic bile duct and pancreatic cancers, if a proper subset of patients is identified, and a rational and aggressive scheme of multimodality treatment is designed [29, 30, 31].…”

Section: General Treatment Rulesmentioning

confidence: 99%

Brachytherapy in the treatment of bile duct cancer – a tough challenge

Skowronek¹,

Zwierzchowski²

2017

jcb

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The majority of patients with bile duct cancer are diagnosed with clinically advanced disease. Most of these patients have a short life expectancy and are treated with palliative aim. Most patients present with locally advanced or metastatic disease, which is not amenable to surgical resection, resulting in poor survival. Adjuvant or definitive radiotherapy, with or without chemotherapy, is therefore used in many centers worldwide for better local control, and with the expectation that it will have a favorable effect on survival. However, the lack of appropriate prospective trials, as well as the small size of the published series and their retrospective nature, has produced insufficient evidence for the best treatment for these patients. Intraluminal brachytherapy is an important component in the multimodality approach to bile duct cancers. The objective of this treatment is to deliver a high local dose of radiation to the tumor while sparing surrounding healthy tissues. The treatment can be safely adapted for right and left hepatic duct, and for common bile duct lesions. Brachytherapy plays a limited but specific role in definitive treatment with curative intent in selected cases of early disease, as well as in the postoperative treatment of small residual disease. Depending on the location of the lesion, in some cases, brachytherapy is a treatment of choice. Clinical indications, different techniques, results, and complications are discussed in this work.

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“…In den letzten Jahren gewinnt die Bestrahlungstherapie der malignen Gallengangs verschlüsse zunehmend an Bedeutung. Die anfänglich ange wandte perkutane Strahlentherapie mußte wegen der Gefahr lokaler und systemischer Nebenwirkungen auf 40-50 Gy beschränkt bleiben [9,10,14,20,21,29,31]. Die Neuentwick lung einer intraluminalen Bestrahlung mit Iridium oder Radium bot die Möglichkeit, hohe Strahlendosen in das Zen trum des Tumors zu bekommen [3,7,8,12,17,22,23,30].…”

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Kombinierte intraduktale und perkutane Radiotherapie bei maligner Gallenwegsobstruktion mit anschließender prothetischer Versorgung

Brambs¹,

Freund²,

Bruggmoser³

et al. 1987

Oncol Res Treat

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Die Strahlentherapie hat beim inoperablen malignen Verschlußikterus das Ziel, die Überlebenszeit gegenüber der palliativen Drainage zu verlängern. Bevorzugt wird eine Kombination einer intrakavitären Brachytherapie über eine perkutantranshepatische Drainage (30–40 Gy in 1 cm Abstand) mit einer perkutanen Pendelfeldbestrahlung (30–40 Gy). Diese Kombination erlaubt hohe lokale Tumordosen bei einem relativ großen Bestrahlungsvolumen. Nach Abschluß der Radiotherapie wird die PTD gegen eine dicklumige Prothese (14 F) ausgewechselt.

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The role of radiation therapy in carcinoma of the extrahepatic bile ducts

Cited by 35 publications

References 35 publications

Review article: Biliary tree malignancies

Review article: Biliary tree malignancies

Brachytherapy in the treatment of bile duct cancer – a tough challenge

Kombinierte intraduktale und perkutane Radiotherapie bei maligner Gallenwegsobstruktion mit anschließender prothetischer Versorgung

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