The Role of Pylorus-Preserving Duodenopancreatic Head Resection

Kozuschek, W.; Reith, H.B.; Haarmann, W.

doi:10.1007/978-3-642-77437-9_46

Cited by 5 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Issues favouring preservation of the pylorus are improved postoperative weight gain and avoidance of postgastrectomy syndromes10, 11, 13, 15, 25. The results in terms of nutritional status and quality of life are, however, inconsistent; some authors have observed improved weight gain and quality of life after pylorus‐preserving resection31, 32, but others have not33, 34. These divergent views are, however, based on retrospective or non‐randomized prospective studies.…”

Section: Discussionmentioning

confidence: 99%

Randomized clinical trial of pylorus-preserving duodenopancreatectomy versus classical Whipple resection—long term results

Seiler

Wagner

Bachmann

et al. 2005

British Journal of Surgery

246

147

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Randomized clinical trial of pylorus-preserving duodenopancreatectomy versus classical Whipple resection—long term results

Seiler

Wagner

Bachmann

et al. 2005

British Journal of Surgery

246

147

View full text Add to dashboard Cite

show abstract

“…During the last years morbidi ty and mortality have decreased significantly. The mortal ity rate for major pancreatic resections is now under 10% and should not exceed the 5% rate [7,16,[20][21][22], At the University of Bern we achieved a zero mortality rate in 133 major pancreatic surgeries performed within a 14-month period, 78 of them being resections of the head of the pancreas. However morbidity after duodenopancreatectomy is still substantial, even in experienced hands.…”

Section: International Resultsmentioning

confidence: 99%

“…(2) By preserving the pylorus and the stomach, the function of these organs is not altered and the well-known postgastrectomy 'dumping' and 'af ferent loop' syndromes are avoided [19]. (3) This im proved gastrointestinal function goes parallel with an improved postoperative gain of weight compared to the standard Whipple procedure, as shown in patients who postoperatively gained more than a 100% of their pre disease weight and an excellent quality of life [20][21][22]. (4) The occurrence of postoperative gastric ulcerations has been claimed to be a typical problem of pylorus-pre serving duodenopancreatectomy in earlier studies.…”

Section: Advantages and Disadvantagesmentioning

confidence: 99%

“…On the other hand, Klinkenbijl et al [21] were unable to show any difference between the two procedures in similarly TNM-staged patients (26 vs. 24) with carcinoma of the head of the pan creas. So did Kozuschek et al [22]; they found no differ ence between the two operative techniques in regard of survival within similarly TNM-staged patients (24 vs. 19) with carcinoma of the head of the pancreas [21,22,25] ( fig. 5).…”

Section: Oncologic Radicallymentioning

confidence: 99%

See 1 more Smart Citation

The Role of Pylorus-Preserving Duodenopancreatectomy in Pancreatic Cancer

Seller¹,

Wagner²,

Büchler³

1994

Dig Surg

View full text Add to dashboard Cite

Although the history of duodenopancreatectomy is very old there is still an ongoing discussion on whether the pylorus-preserving type of duodenopancreatectomy should be done in patients with cancer of the pancreatic head. Recent data convincingly show a trend to consider the pylorus-preserving type of duodenopancreatectomy in pancreatic cancer as an excellent alternative. Though the experience with pancreatic cancer disease is not yet conclusive, the fascinating benefit of the pylorus-preserving duodenopancreatectomy has result in a reduction of surgical trauma, a decrease of operating time, a reduction of blood loss and very importantly, optimal postoperative digestion and nutrition due to the preservation of the antrum pylorus unit, resulting in an overall improvement in quality of life compared to the standard Whipple procedure. Recent data show an equal survival rate and incidence of locoregional recurrences or distant metastasis with both types of operation. This phenomenon still needs to be confirmed since so far no randomised prospective study comparing the standard Whipple operation with pylorus-preserving duodenopancreatectomy in pancreatic cancer has been done.

show abstract

Das pT4-Pankreaskarzinom: Chirurgische und multimodale Behandlung

Z’graggen

Friess

Wagner

et al. 1999

Acta Chir Austriaca

View full text Add to dashboard Cite

K. Z'graggen, tL Friess, M. Wagner und M. W. B&'hler Schliisselwiirte,v Pankreaskarz.im,n -chirurgische The'nq~ie -Chemotherapie .-Radiotherepie. Ke3-words: Pancreatic ccmcer --surgery -chemotherapy--radiotherapy. Zusammenfassung: Grundlage~: Die Resektion, unterstfitzt durch multimodale Therapieschemata, gilt auch beim T4-Pankreaskarzinom als einzige kurative Therapie. Methodik: Beim T4-Pankreaskarzinom mug h',iufig ein erweitertes Resektionsverfahren gew~ihlt werden, das eine En-bloc-Emfernung des Tumors erlzmbt und heute mit einer niederen Morbiditiit und Moralittit vorgenommen werden kann. Der Stellenwert der l,ymphknotendissektion bei diesen lokal fortgeschrittenen Pankreaskarzinomen ist nicht geklfirt. Die hohe Lokalrezidivmte kann eventuell dnrch eine radikatere Lymphknotendissektion zusammen mit einer priioperativen, intraoperativen oder postoperativen kombinierten Chcmotherapie verbessert werden. ~ebnisse: Die Ergebnisse mulfimodaler Therapieschemata zur Bchandlung des Pankreaskarzinoms werden vorgestellt und der Steltenwcrt der cinzelnen potentielt kurativen und palliativen Modalit~iten diskutiert. Sch!t!gfo! ,eg.cL~ngeo: Obwohl der Einflu/3 auf Lokahezidivraten und Uberleben beim T4-Pankreaskarzinom noch nicht gektlirt isL schcint eine muttimoda/e Behandlung bei der Gesamtgruppe der Patienten mit Pankreaskarzinom diesbeztiglich bessere Resultate zu erzieten. Diese Resuhate werden in Zukunft noch in prospektiv randomisiert durchgefiJhrten Multicenter-Studien geklttrt werden. The pT4-Carcinoma of the Pancreas: Surgical andMultimodal Treatment Summary: Ba.ckgmund: Pancreatic resection and multimodal treatment are today the only potentially curative treatments for patients with T4-pancreatic cancer. Methods: Extended resections for the minors can now be carried out with an acceptably tow morbidity and mortality. The necessary extent of lymph node dissection in these locally advanced cancers is still under investigation, but local recurrence rates seem to be decreased when aggressive surgical strategies are combined with pre-, intra-, or postoperative chemoradiation. Results: The results of multimodal treatments for pancreatic cancer are presented in the current review and potentially curative and palliative treatment options discussed. Conclusions: Although the influence of a combined surgical and chemoradiation treatmm~t seems to improve !ocaI recto-fence rates and surviva! in patieets with pancreatic cancer, the subgroup of T4-stages has not been properly eva!ua~ed. The results of ongoing prospective randomized multicenter studies will determine the importance of the different treatment modalities. EinfiihrungDie Resektion ist bei Patienten rail Pankreaskarzinom noch immer das einzige Therapieveffahren mit der

show abstract

The Role of Pylorus-Preserving Duodenopancreatic Head Resection

Cited by 5 publications

References 19 publications

Randomized clinical trial of pylorus-preserving duodenopancreatectomy versus classical Whipple resection—long term results

Randomized clinical trial of pylorus-preserving duodenopancreatectomy versus classical Whipple resection—long term results

The Role of Pylorus-Preserving Duodenopancreatectomy in Pancreatic Cancer

Das pT4-Pankreaskarzinom: Chirurgische und multimodale Behandlung

Contact Info

Product

Resources

About