The role of public involvement in the design of the first SARS-CoV-2 human challenge study during an evolving pandemic

Piggin, Maria; Smith, Emma; Mankone, Peter; Ndegwa, Leah; Gbesemete, Diane; Pristerà, Philippa; Bahrami‐Hessari, Michael; Johnson, Halle; Catchpole, Andrew; Openshaw, Peter; Chiu, Christopher; Read, Robert C.; Ward, Helen; Barker, Caroline

doi:10.1016/j.epidem.2022.100626

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Background On the Ethics Of Chim And Unresolved Issues In Th...1

Nonhuman Primate and Human Challenge Models1

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2023

2024

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“…Extensive engagement with policymakers and experts occurred, but the public engagement model was also important. Public and prospective participants were engaged through specialist groups at Imperial College London and the University of Southampton [ [11] , [12] , [13] ].…”

Section: Background On the Ethics Of Chim And Unresolved Issues In Th...mentioning

confidence: 99%

Ethical approval for controlled human infectious model clinical trial protocols – A workshop report

Jamrozik,

Littler,

Meln

et al. 2024

Biologicals

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Section: Background On the Ethics Of Chim And Unresolved Issues In Th...mentioning

confidence: 99%

Ethical approval for controlled human infectious model clinical trial protocols – A workshop report

Jamrozik,

Littler,

Meln

et al. 2024

Biologicals

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“…Chiu led the development of a SARS-CoV-2 human challenge model during the pandemic, aiming to demonstrate the kinetics of viral load and symptomatology, highlighting the granularity of data for mathematical modeling [3,15,32]. T cell activation negatively correlated with viral load and duration of viral shedding.…”

Section: Nonhuman Primate and Human Challenge Modelsmentioning

confidence: 99%

Scientific highlights of the 9th ESWI Influenza Conference

Reperant,

Russell,

Osterhaus

2024

One Health Outlook

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The European Scientific Working Group on Influenza (ESWI) held the 9th ESWI Influenza Conference in Valencia from 17—20 September 2023. Here we provide a summary of twelve key presentations, covering major topics on influenza virus, respiratory syncytial virus (RSV) and SARS coronavirus 2 (SARS-CoV-2) including: infection processes beyond acute respiratory disease, long COVID, vaccines against influenza and RSV, the implications of the potential extinction of influenza B virus Yamagata lineage, and the threats posed by zoonotic highly pathogenic avian influenza viruses.

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