The role of psychosocial factors in the development of breast carcinoma: Part II

Price, Melanie A.; Tennant, Christopher; Butow, Phyllis; Smith, Ross C.; Kennedy, Susan; Kossoff, Marjorie B.; Dunn, Stewart M.

doi:10.1002/1097-0142(20010215)91:4<686::aid-cncr1052>3.0.co;2-0

Cited by 68 publications

(20 citation statements)

References 60 publications

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“…Of the studies that have evaluated stressful life events and breast cancer risk, most have evaluated only adult exposure to stress [40,42–44, 46, 48, 49, 51], and a lifecourse perspective was rarely used [39, 45]. In the European Prospective Investigation into Cancer (EPIC) Study, although none of the results reached statistical significance, the strongest association was observed for losses in adulthood (hazard ratio per “loss” event in past 5 years = 1.21, 95% CI: 0.98, 1.51) [45].…”

Section: Discussionmentioning

confidence: 99%

“…However, current empirical evidence provides little support for an independent association between “stress” from various sources and breast cancer risk: while some studies report positive [38–41] or inverse [42] associations, most studies find no association [43–51]. Of note, few studies have evaluated differences in risk according to “resilience,” the ability to adapt successfully to acute stress.…”

Section: Introductionmentioning

confidence: 99%

“…Of the four studies that have evaluated the modifying effects of coping or social/emotional support on the association between stress and breast cancer [38, 46, 49, 51], three studies found evidence of effect modification by these factors [38, 49, 51]. Specifically, a recent case–control study found that women who experienced a life stressor and reported no intimate emotional support were significantly more likely to develop breast cancer than those who experienced a life stressor but reported good emotional support [51]; an earlier case–control study found that, contrary to expectation, the women who experienced at least one severe life event within 5 years of diagnosis and who used coping skills to confront their stress had a higher risk of breast cancer than those who did not confront their stress [38]; and a recent prospective analysis of Women’s Health Initiative data found that breast cancer risk increased monotonically with increasing number of stressful events among those with high but not low social support [49]. Other studies of coping in relation to breast cancer have found no direct association [50].…”

Section: Introductionmentioning

confidence: 99%

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Abuse victimization and risk of breast cancer in the Black Women’s Health Study

Wise

Palmer

Boggs

et al. 2011

Cancer Causes Control

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Few studies have examined the relation between abuse victimization and breast cancer, and results have been inconclusive. Using data from 35,728 participants in the Black Women’s Health Study, we conducted multivariable Cox regression to estimate incidence rate ratios (IRRs) and 95% confidence intervals (CI) for the association of abuse across the life span (childhood, adolescence, and adulthood) with breast cancer. Incident breast cancer diagnoses were reported during 1995–2009, and abuse histories were reported in 2005. No associations were found between abuse victimization in either childhood or adolescence and breast cancer. We found a weak positive association between abuse in adulthood and breast cancer (IRR = 1.18, 95% CI = 1.03–1.34). IRRs for physical abuse only, sexual abuse only, and both physical and sexual abuse in adulthood, relative to no abuse, were 1.28 (95% CI = 1.09–1.49), 0.96 (95% CI = 0.76–1.20), and 1.22 (95% CI = 1.00–1.49), respectively. IRRs for low, intermediate, and high frequencies of physical abuse in adulthood, relative to no abuse, were 1.28 (95% CI = 1.07–1.52), 1.37 (95% CI = 1.04–1.79), and 1.24 (95% CI = 0.95–1.62), respectively. Our data suggest an increased risk of breast cancer among African-American women who reported physical abuse in adulthood, but there was little evidence of a dose–response relation. These results require confirmation in other studies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Abuse victimization and risk of breast cancer in the Black Women’s Health Study

Wise

Palmer

Boggs

et al. 2011

Cancer Causes Control

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“…The recent study by Peled et al (2008) (255 cases, 367 controls under the age of 45 years) observed that accumulation of more than one severe life event is positively associated with breast cancer (OR ¼ 1.62, 95% CI: 1.09 -2.40). In contrast, findings from some other studies (Roberts et al 1996;Protheore et al 1999;Price et al 2001;Ollonen et al 2005) reported no association between stressful life events and risk of breast cancer. The findings from our study are also consistent with our previous research (257 breast cases operated on during 1993 to 1998, 565 controls) that showed that accumulation of major life events increased breast cancer risk (OR ¼ 3.93, 95% CI: 1.88 -6.18) compared with those who reported no stress.…”

Section: Discussionmentioning

confidence: 80%

Self-reported psychological stress and the risk of breast cancer: A case-control study

Kruk

2011

Stress

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The aim of this study was to examine the relationship between severe life events and breast cancer risk. This study was based on a case-control examination of 858 Polish invasive breast cancer cases and 1085 controls matched for age and place of residence. Data on life events, sociodemographic characteristic, reproductive factors, family history of breast cancer, current weight and height, and lifestyle habits were collected between January 2003 and May 2007 using a self-administered questionnaire. Odds ratios with 95% confidence intervals were estimated as the measure of the relationship between life event stress and breast cancer risk using unconditional logistic regression analyses. After adjustment for potential breast cancer risk factors, women with four to six individual major life events had 5.33 times higher risk for breast cancer, compared with those in the lowest quartile. Similarly, women with a lifetime life change score greater than 210 had about 5 times higher risk compared to women with corresponding scores in the range 0-70. Several life events (death of a close family member, personal injury or illness, imprisonment/trouble with the law, retirement) were significantly associated with breast cancer risk. These findings suggest that major life events can play an important role in the etiology of breast cancer.

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“…A growing number of studies have suggested that chronic stress has specific effects on the immune systems of cancer patients (Price et al 2001; Reiche et al 2004; Spiegel and Giese-Davis 2003). Although stress cannot directly cause cancer, the increased secretion of NE and E, the two important sympathetic mediators (Herman et al 1996; McEwen 2007) which usually act as immunosuppressors promote favorable environment for tumor cells to grow and metastasize (Inbar et al 2011).…”

Section: Ne E and Tumor Immunitymentioning

confidence: 99%

Neurotransmitters as Regulators of Tumor Angiogenesis and Immunity: The Role of Catecholamines

Sarkar

Chakroborty

Basu

2012

J Neuroimmune Pharmacol

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The growing tumor employs various strategies to establish its growth, progression and spread in the host. Angiogenesis or formation of new blood vessels from existing ones and escape from immune surveillance are the two critical steps that ensure proper establishment and growth of the newly formed tumor. Thus understanding the novel pathways associated with tumor angiogenesis and immunity may lead to the development of newer therapeutic strategies using the regulators of these pathways to improve patient outcomes. These two pivotal steps in the process of tumorigenesis are governed by plethora of endogenous factors. The neuroendocrine molecules, which include the catecholamine neurotransmitters, dopamine, norepinephrine and epinephrine are of growing interest considering their varied and diverse regulatory roles both in the process of tumor angiogenesis and tumor immunity. This review focuses on the emerging roles of catecholamines in modulating tumor angiogenesis and immunity, and also discusses the probable molecular mechanisms of their actions. Understanding of this new group of endogenous regulators of tumor growth may lead to the development of newer therapeutic approaches for the treatment of cancer.

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The role of psychosocial factors in the development of breast carcinoma: Part II

Cited by 68 publications

References 60 publications

Abuse victimization and risk of breast cancer in the Black Women’s Health Study

Abuse victimization and risk of breast cancer in the Black Women’s Health Study

Self-reported psychological stress and the risk of breast cancer: A case-control study

Neurotransmitters as Regulators of Tumor Angiogenesis and Immunity: The Role of Catecholamines

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