The role of psychological factors in functional gastrointestinal disorders: a systematic review and meta-analysis

Yan, Liyanran; Zhang, Xueli; Li, Yan; Liu, Chengjiang; Yang, Hua; Yang, Chun‐Chun

doi:10.1007/s00384-023-04333-9

Cited by 7 publications

(11 citation statements)

References 97 publications

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“…Recently, the significant role of psychosocial factors in functional dyspepsia has been acknowledged by mainstream researchers [ 18 ]. A significant association between anxiety, depression, and functional dyspepsia was also demonstrated by a meta-analysis from 2023 [ 19 ]. In our study, depression symptoms were shown to account for 41.5% of HAMD, 61.3% of SDS, 36.6% of HADS-D, and 56.3% of PHQ-9.…”

Section: Discussionmentioning

confidence: 94%

Application and value of anxiety and depression scale in patients with functional dyspepsia

Ruan,

Lin,

et al. 2024

BMC Psychol

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Background Patients with functional dyspepsia (FD) cannot be assessed for their mental health using a suitable and practical measure. The purpose of the study is to investigate the usefulness of several anxiety and depression scales in patients with FD, offering recommendations for clinical identification and therapy. Methods From September 2021 to September 2022, patients were sought and selected. The psychological symptoms were assessed using ten depression or anxiety questionnaires. The receiver operating characteristic (ROC) curve, Spearman analysis, Pearson correlation analysis, and single factor analysis were applied. Results Prospective analysis was performed on 142 healthy individuals and 113 patients with FD. In the case group, anxiety and depression symptoms were more common than in the control group, and the 10 scales showed strong validity and reliability. HAMD had the strongest connection with the PHQ-9 score on the depression scale (0.83). The score correlation between SAS and HAMA on the anxiety analysis scale was the greatest at 0.77. The PHQ-9, SAS, HAMD, and HAMA measures performed exceptionally well in detecting FD with anxiety or depression symptoms (AUC = 0.72, 0.70, 0.70, 0.77, and 0.77, respectively). Conclusions PHQ-9, SAS, HAMD, and HAMA scales have good application performance in FD patients. They can assist gastroenterologists in evaluating anxiety and depression symptoms, and provide reference and guidance for subsequent treatment.

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Section: Discussionmentioning

confidence: 94%

Application and value of anxiety and depression scale in patients with functional dyspepsia

Ruan,

Lin,

et al. 2024

BMC Psychol

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“…Patients with DGBI may have impaired somatic activity, as they are likely to have somatization. 18 Importantly, in patients with non‐EoE EGIDs, decreased mental‐health‐related QOL was significantly correlated with the level of anxiety but not depression. Therefore, we consider that anxiety is a more prominent mental status than depression, and anxiety may modulate the disease status of non‐EoE EGIDs.…”

Section: Discussionmentioning

confidence: 95%

“…Accordingly, the characteristics regarding depression and physical‐health‐related QOL might be different between the DGBI and non‐EoE EGIDs groups. Patients with DGBI may have impaired somatic activity, as they are likely to have somatization 18 . Importantly, in patients with non‐EoE EGIDs, decreased mental‐health‐related QOL was significantly correlated with the level of anxiety but not depression.…”

Section: Discussionmentioning

confidence: 96%

Correlation between anxiety and decreased quality of life in patients with non‐esophageal eosinophilic gastrointestinal diseases

Tanaka,

Kanamori,

Sawada

et al. 2023

JGH Open

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Background and AimMental status such as anxiety and depression in patients with non‐esophageal eosinophilic gastrointestinal diseases (non‐EoE EGIDs) has not been studied. The aim of this study was to evaluate whether patients with non‐EoE EGIDs had mental disorders and decreased mental‐health‐related quality of life (QOL) similar to those in patients with disorders of gut–brain interaction (DGBI).MethodsWe enrolled patients with non‐EoE EGIDs and DGBI visiting the Osaka Metropolitan University Hospital, and the measures listed below were compared between the groups. We collected data using the following questionnaires: hospital anxiety and depression scale, and short form (SF)‐8 including mental component summary (MCS)‐8.ResultsWe evaluated 21 and 17 patients with non‐EoE EGIDs and DGBI, respectively. The anxiety score was not significantly different between the groups. The proportion of patients with possible anxiety was not significantly different between the groups (19.0% vs 33.3%). These results show that patients with non‐EoE EGIDs had anxiety that might be equivalent to that of patients with DGBI. The depression score and proportion of patients with possible depression in the non‐EoE EGID group tended to be lower than those in the DGBI group. MCS‐8 scores were not significantly different between the non‐EoE EGID and DGBI groups, which might imply an equivalent decrease in mental‐health‐related QOL in both groups of patients. In patients with non‐EoE EGIDs, the anxiety score had a significant inverse association with the MCS‐8 score.ConclusionsPatients with non‐EoE EGIDs may have anxiety that correlates with decreased mental‐health‐related QOL.

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“…Regarding psychological factors, previous studies have suggested that psychological comorbidities significantly impact the QoL of patients with DGBIs, even more so than GI symptoms [16]. Hence, psychological factors interact with gastrointestinal symptoms and form a vicious circle that can slow recovery and exacerbate healthcare seeking [17].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the growing number of studies on the psychosocial correlates of DGBIs [16,19], most of the previous literature is methodologically limited, being characterized by diagnoses made through self-report measures, unmatched control groups, or investigation of a small number of biopsychosocial correlates. Thus, the aims of this study were two-fold: (i) to test for significant differences between carefully selected patients with a DGBI and age-, sex-, and education-matched controls in several biological (e.g., gastrointestinal symptoms), psychological (e.g., anxiety and depression, emotion dysregulation, insecure attachment, alexithymia, somatosensory amplification) and social (e.g., interpersonal problems) factors; and (ii) to examine the potential biopsychosocial predictors of QoL, among both patients with DGBIs and healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life and Its Psychosocial Predictors among Patients with Disorders of Gut–Brain Interaction: A Comparison with Age- and Sex-Matched Controls

Brugnera,

Remondi,

La Tona

et al. 2024

Healthcare

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The disorders of gut–brain interaction (DGBIs) are a heterogeneous group of chronic conditions that greatly reduce patients’ quality of life (QoL). To date, biopsychosocial factors (such as gastrointestinal symptoms, alexithymia, and interpersonal problems) are believed to contribute to the development and maintenance of DGBIs, but their role in affecting patients’ QoL is still under investigation. Out of 141 patients seeking treatment for their gastrointestinal symptoms, 71 were diagnosed with a DGBI (47 females, 66.2%; Mage: 41.49 ± 17.23 years) and were age- and sex-matched to 71 healthy controls (47 females, 66.2%; Mage: 40.45 ± 16.38 years) without any current gastrointestinal symptom or diagnosis. Participants completed a sociodemographic and clinical questionnaire and a survey investigating several psychosocial risk factors. We found greater symptom severity and difficulties in identifying feelings among patients compared to controls. Further, multiple linear regression analyses evidenced that, among patients, higher expressive suppression of emotions, difficulties in identifying feelings and interpersonal problems, and a lower cognitive reappraisal of emotions predicted lower QoL. Data suggest that the QoL of patients with DGBIs is affected not only by common risk factors (e.g., interpersonal problems) but also by specific difficulties in processing and regulating emotions. The implications of these findings are discussed.

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The role of psychological factors in functional gastrointestinal disorders: a systematic review and meta-analysis

Cited by 7 publications

References 97 publications

Application and value of anxiety and depression scale in patients with functional dyspepsia

Application and value of anxiety and depression scale in patients with functional dyspepsia

Correlation between anxiety and decreased quality of life in patients with non‐esophageal eosinophilic gastrointestinal diseases

Quality of Life and Its Psychosocial Predictors among Patients with Disorders of Gut–Brain Interaction: A Comparison with Age- and Sex-Matched Controls

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