The Role of Psychiatric, Analgesic, and Antiepileptic Medications in Chronic Pruritus

Patel, Parth M.; Patel, Keshav; Pandher, Karan; Tareen, Ruqiya Shama

doi:10.7759/cureus.17260

Cited by 4 publications

(6 citation statements)

References 33 publications

(82 reference statements)

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“…It should be noted, however, that butorphanol has no registration for these indications and is used off-label, including in refractory cases of pruritus [117]. Naloxone and naltrexone -opioid receptor antagonists -are used in the treatment of cholestatic and uremic pruritus [118]; however, opioid-induced pruritus is not an indication of their use. Anxiolytics and/or antidepressants from the selective serotonin reuptake inhibitor (SSRI) group, such as paroxetine at a dose of 20 mg/day Forum Dermatologicum 2024, Vol.…”

Section: Treatmentmentioning

confidence: 99%

Pruritus in elderly patients: review of literature

Mazan,

Lesiak,

Narbutt

2024

Forum Dermatologicum

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Pruritus is the most common symptom reported by dermatology patients, including the geriatric patient population. Due to population ageing, pruritus will be an increasingly common reason for medical consultations. Pruritus can involve both previously affected and unaffected skin, occurring as the only manifestation of the disease. Chronic pruritus lasting more than six weeks has a significant impact on patients' quality of life, often resulting in sleep disorders and depressive-anxiety disorders. Mechanisms responsible for pruritus in the elderly include abnormal dermal-epidermal barrier, age-related changes in the immune system, and central and peripheral neuropathy. Xerosis is considered the most common cause of pruritus in geriatric patients. Chronic pruritus occurs in the course of many dermatological conditions, as well as Internal diseases, and neurological or psychiatric disorders. The treatment of chronic pruritus in elderly patients may sometimes be a therapeutic challenge due to comorbidities or the complexity of the mechanisms leading to its onset. Each patient needs an individual and often multidisciplinary approach, taking into account comorbidities and polypragmasia. In addition to emollient skincare -which is the basis of skin care -and topical anti-inflammatory preparations for inflammatory skin disorders, biologics are increasingly being used in the treatment of pruritus, as well as drugs with antidepressant and antiepileptic effects.

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Section: Treatmentmentioning

confidence: 99%

Pruritus in elderly patients: review of literature

Mazan,

Lesiak,

Narbutt

2024

Forum Dermatologicum

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“…Table 2 features several topical, systemic, and procedural therapeutics utilized by the authors in the management of neuropathic pruritus patients with variable success. Topical medications may work for a short time to relieve pruritus by various mechanisms, including anesthesia via lidocaine and pramoxine, topical ketamine and amitriptyline, peripheral nervous system activation via capsaicin, antihistamine, and antiserotonin/norepinephrine properties such as doxepin [37] . These treatments are often more effective for localized conditions such as brachioradial pruritus, scalp dysesthesia, or notalgia paresthetica [38] .…”

Section: Treatmentsmentioning

confidence: 99%

United States expert panel consensus on uniform nomenclature and diagnosis for neuropathic pruritus

Kwatra,

Elmariah,

Chisolm

et al. 2023

Itch

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Importance: Neuropathic pruritus is a debilitating condition lacking a uniform approach to nomenclature and diagnosis. Objective: A panel of dermatologist experts in pruritus was convened to develop definitions, diagnostic recommendations, and treatment guidelines for neuropathic pruritus. Evidence review: A roundtable discussion of 10 experts was conducted on November 3, 2021, via the Zoom platform. This study follows the Standards for Reporting Qualitative Research reporting guidelines for qualitative studies. A systematic review of prior literature on the definition, scope, diagnostic, and treatment was performed, looking at sources of treatment from 1991 to 2021. Consensus was defined as >70% agreement for acceptance of a definition or recommendation. A draft of evidence was subjected to revision by all participants and was endorsed by all participants. Findings: The roundtable identified definitions for neuropathic pruritus, which included different forms of the condition based on cause and presentation such as brachioradial pruritus, notalgia paresthetica, and scalp pruritus. Diagnostic and treatment guidelines were also established. Limitations of this process included lack of randomized controlled studies. These recommendations are also based on expert consensus and must be further supported by evidence-based outcomes research. Conclusions: Neuropathic pruritus contains numerous subtypes, causes, diagnostic methods, and treatment modalities. The recommendations developed by this panel are meant to serve as shared nomenclature for future clinical studies.

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“…Świąd można podzielić na okresowy -ostry, trwający do sześciu tygodni i przewlekły trwający dłużej niż sześć tygodni. Według panującej wiedzy, około 8% dorosłej populacji cierpi na przewlekły świąd [6]. Towarzyszy on wielu chorobom, w tym dermatologicznym, układowym, neurologicznym i psychiatrycznym.…”

Section: Gabapentyna W Dermatologii Terapia śWiądu Przewlekłegounclassified

Gabapentin as a drug with a broad potential. Presentation of its use in medical conditions beyond the official registration

Banasiak¹,

Pierzchała²,

Bednarz³

et al. 2022

J Educ Health Sport

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Introduction: Gabapentin is a drug used for monotherapy or adjunctive therapy of simple and complex partial epileptic seizures in adults and children. It is also used to treat neuropathic pain for adults. There are reports in the medical literature of the effective use of gabapentin in the treatment of other conditions. Let's take a closer look at its therapeutic potential.Aim of the study: The overview of current literature knowledge about the usage of gabapentin in various medical conditions within the fields of toxicology, dermatology, gynecology, psychiatry branches' issues, with indicating the potential abuse. Materials and Methods: We reviewed the literature available in the PubMed database, using the keywords.Results: Gabapentin is an anticonvulsant drug structurally similar to gamma-aminobutyric acid (GABA). It is considered to be a centrally acting analog of GABA, nevertheless, it presents a different molecular mechanism comparing to the other drugs that affect GABA-ergic transmission. The registered indications for its use are the treatment of seizures within adults and children and neuropathic pain in adults. The literature reveals that gabapentin is also used in the treatment of alcohol abuse disorders within the patients with alcohol withdrawal symptoms, the treatment of pruritus, hot flashes during menopause and the treatment of anxiety disorder. Summary: Due to the ambiguous effects of gabapentin usage, it can be applied to treat various medical conditions. Nevertheless, the usage of this drug described in the literature requires additional studies on a larger group of patients to confirm the findings.

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The Role of Psychiatric, Analgesic, and Antiepileptic Medications in Chronic Pruritus

Cited by 4 publications

References 33 publications

Pruritus in elderly patients: review of literature

Pruritus in elderly patients: review of literature

United States expert panel consensus on uniform nomenclature and diagnosis for neuropathic pruritus

Gabapentin as a drug with a broad potential. Presentation of its use in medical conditions beyond the official registration

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