2014
DOI: 10.1002/prca.201300101
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The role of proteomics in understanding biological mechanisms of sepsis

Abstract: Sepsis is a systemic inflammatory state caused by infection. Complications of this infection with multiple organ failure lead to more lethal conditions, such as severe sepsis and septic shock. Sepsis is one of the leading causes of US deaths. Novel biomarkers with high sensitivity and specificity may be helpful for early diagnosis of sepsis and for improvement of patient outcomes through the development of new therapies. Mass spectrometry-based proteomics offers powerful tools to identify such biomarkers and f… Show more

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Cited by 41 publications
(49 citation statements)
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References 166 publications
(292 reference statements)
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“…The incidence of pediatric sepsis is higher in developing country where pathogens readily invade children because of low birth weight, water and air pollution as well as insufficient immunization and nutrition [3,4]. Pediatric sepsis is a spectrum of disorders that mainly infected by bacteria, viruses, fungi, parasites or the toxic byproducts of these microorganisms [5,6]. Recently, many epidemiologic data reveal that a majority of severe sepsis attacks children without any predisposing condition [7].…”
Section: Introductionmentioning
confidence: 99%
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“…The incidence of pediatric sepsis is higher in developing country where pathogens readily invade children because of low birth weight, water and air pollution as well as insufficient immunization and nutrition [3,4]. Pediatric sepsis is a spectrum of disorders that mainly infected by bacteria, viruses, fungi, parasites or the toxic byproducts of these microorganisms [5,6]. Recently, many epidemiologic data reveal that a majority of severe sepsis attacks children without any predisposing condition [7].…”
Section: Introductionmentioning
confidence: 99%
“…Microarray data and genome-wide expression profiling also have been increasingly applied to identify novel pathways and therapeutic gene targets, sepsis-related biomarkers [6,[15][16][17]. A microarray-based study in children with septic shock demonstrated that development age is a major contributor to sepsis heterogeneity.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…[33]. Studies further down from the genome to the phenome, at the level of the epigenome, transcriptome, and proteome, have been, to some extent, successful in complementing and expanding our knowledge of disease pathophysiology [34-39]. Nevertheless, as transcriptional and translational elements exist in high numbers of variants and isoforms and are dynamically altered (with unknown time lags) through the interaction with the insulting pathogen, the results of transcriptomics and proteomics research in sepsis, though promising, need to be confirmed before they are applied at the bedside [40].…”
Section: The “-Omics” Cascade In Sepsis Researchmentioning
confidence: 99%
“…This is in sharp contrast with the diagnostic power of certain biomarkers used in the world of "definitive" diseases, where several laboratory parameters have this ability. Nevertheless, there is still an ongoing search for better, new markers of inflammatory response and infection, with promising preliminary results [40].…”
Section: The Role Of Biomarkers At the Bedsidementioning
confidence: 99%