The Role of Proteolytic Enzymes in Focal Ischaemic Brain Damage

Davis, Michelle; Mantle, David; Mendelow, A. D.

doi:10.1007/978-3-7091-6346-7_53

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Additionally, some amount of IgG against the fragments of proteins may appear in the blood of patients with stroke as a consequence of enhancement of stroke-related proteolysis [12]. On the whole, our results are in keeping with work [13] that shows the increase in the level of IgG in the first week after atherothrombotic ischemic stroke.…”

Section: A C C E P T E D a R T I C L Esupporting

confidence: 91%

Effects of IgG from the serum of ischemic stroke patients on hemostasis

et al. 2021

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Ischemic stroke is among the top diseases leading to mortality and disability in the world. The detailed investigation of the mechanisms underlying this pathology and especially mediating the tendency to relapse during the first year after stroke incident undoubtedly belongs to important tasks of modern medicine and biology. The current study aims to analyze the influence of IgG derived from the blood serum of ischemic stroke patients on some hemostasis factors. In total, 123 participants with IS, 62 with atherothrombotic ischemic stroke, 61 with cardioembolic ischemic stroke, and 57 subjects as control have been examined. The same patients have participated in the research a year after stroke. IgG from serum was isolated by affinity chromatography on protein A Sepharose column. The activity of key hemostasis factors under the influence of IgG was analyzed. Obtained results revealed that IgG of stroke patients but not healthy subjects caused the inhibition of the amidolytic activity of endogenously generated thrombin, protein C, factor Xa, and led to an increase in the degree of ADP-induced platelet aggregation. The reduction of clotting time in the test "Thrombin time" by IgG of patients at the acute phase of disease was also observed; IgG of healthy subjects mediated the opposite effect. In contrast to acute ischemic stroke IgG, IgG of patients one year after both atherothrombotic and cardioembolic ischemic stroke influenced only the activity of endogenously generated thrombin and factor Xa resulting in inhibition of their activities. It was also established that IgG of ischemic stroke patients, as well as healthy subjects, stimulated the secretion of tissue plasminogen activator by endotheliocytes.

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Section: A C C E P T E D a R T I C L Esupporting

confidence: 91%

Effects of IgG from the serum of ischemic stroke patients on hemostasis

et al. 2021

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“…In the normal brain, proteases play a key role in the catabolism of cellular and extracellular proteins including peptide neurotransmitters, intracellular signaling proteins, cellular structural proteins, and extracellular matrix proteins (16). Abnormal protease activities have been implicated in the pathogenesis of a diverse number of acute brain injuries such as ischemic stroke and traumatic brain injury, and all types of chronic neurodegenerative disorders (17). For instance, activation of matrix metalloproteinases (MMPs) may play a role in the BBB breakdown after stroke (18,19).…”

Section: Cathepsinsmentioning

confidence: 99%

The Role of Cathepsin B in Ischemia-Reperfusion Injury After Stroke

et al. 2021

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Cathepsins are endolysosomal proteases that can be categorized into different types based on their structures and active-site amino acid residue, including cysteine (cathepsins B, C, F, H, K, L, O, S, V, W, and X), serine (cathepsins A and G), and aspartic (cathepsins D and E). Cathepsins can regulate diverse cellular activities such as the processing and presentation of antigens, the processing and activation of hormones, apoptosis, aging, and autophagy. Recently, cathepsin B has gained attention for its role in various neurological diseases including ischemic stroke, Alzheimer's disease, Parkinson's disease, and traumatic brain injury. This chapter mainly focuses on the role of cathepsin B in brain ischemia-reperfusion injury in animal models of stroke.

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The Role of Proteolytic Enzymes in Focal Ischaemic Brain Damage

Cited by 2 publications

References 21 publications

Effects of IgG from the serum of ischemic stroke patients on hemostasis

Effects of IgG from the serum of ischemic stroke patients on hemostasis

The Role of Cathepsin B in Ischemia-Reperfusion Injury After Stroke

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