The role of prostaglandin F2α in human parturition

Gréen, K.; Bygdeman, M.; Toppozada, M.; Wiqvist, N.

doi:10.1016/0002-9378(74)90174-4

Cited by 138 publications

(23 citation statements)

References 11 publications

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“…The high lev els are only sustained for a short time before returning to second stage levels. These results confirm those reported by others [1][2][3]. However, none of these authors com pared the effect of the oxytocics on PGFM levels with that produced when no oxytocic was given.…”

Section: Discussionsupporting

confidence: 81%

“…In an effort to study these factors, we measured the levels of 13,14-dihydro-15-keto prosta glandin F2a (PGFM), the major circulating metabolite of prostaglandin F2a in peripheral blood obtained during the third stage of labour, and the effect of various oxyto cics on the levels of the metabolite. It is well known that measurements of the metabolites are more reliable for monitoring the biosynthesis of the parent PG, as these are more stable and found in considerable higher con centrations [1],…”

Section: Introductionmentioning

confidence: 99%

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Effect of Oxytocics on Prostaglandin Levels in the Third Stage of Labour

Ilancheran

Ratnam²

1990

Gynecol Obstet Invest

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The levels of prostaglandin F₂_Α metabolites (PGFM) in the peripheral blood were measured during third stage in a group of patients not given any oxytocic and this was compared with the levels produced in other groups given different oxytocics. There was a significant rise in PGFM within 5 min of delivery in all groups but there was no statistical difference in the serum concentrations of PGFM between the different groups. This suggests that oxytocics given during third stage do not act through release of prostaglandins.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Effect of Oxytocics on Prostaglandin Levels in the Third Stage of Labour

Ilancheran

Ratnam²

1990

Gynecol Obstet Invest

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“…The increase in the concentration of PGFM before the rise in PG levels may be a reflection of the slower rate of clearance of the metabolite compared to the parent compound, PGF-2oc. PGFM is not formed during collection of blood although PGF-2a may be synthesized by platelets (Green, Bygdeman, Toppozada & Wiqvist, 1974). However, particular care was taken during sampling to ensure that cells were not damaged, and this is supported by the low basal values of PGF-2a before and after parturition (Text-figs 1 & 2).…”

Section: Resultsmentioning

confidence: 99%

Pre-partum changes in the plasma concentrations of progesterone, relaxin, prostaglandin F-2 and 13,14-dihydro-15-keto prostaglandin F-2 in meclofenamic acid-treated sows

Gooneratne¹,

Bryant‐Greenwood²,

Walker³

et al. 1983

Reproduction

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Summary. The pre-partum plasma concentrations of progesterone, relaxin, PGF\x=req-\ 2\g=a\and 13,14-dihydro-15-keto PGF-2\g=a\(PGFM) were determined in 6 sows treated with meclofenamic acid (5\m=.\0mg/kg body wt daily, from Day 109 to Day 113 of pregnancy), and 2 sows which farrowed prematurely. The inhibition of PG synthesis with meclofenamic acid did not prevent either the decline in plasma progesterone or the release of relaxin. Three distinct stages in the progressive changes of the above hormones were apparent before parturition: (1) the gradual decline in the concentrations of progesterone from about 7 days pre partum to reach <4\m=.\5 ng/ml at farrowing; (2) a surge in relaxin levels (>100 ng/ml) by 2 daysprepartum; and (3) sharp increases in the concentrations of PGF-2\g=a\and PGFM within 24 h of parturition. Maximal concentrations of PGF-2\g=a\(>0\m=.\5 ng/ml) and PGFM (>20\m=.\0 ng/ml) occurred during farrowing. It is suggested that PG from an extra-ovarian source may not be responsible for initiating functional regression of the corpora lutea in the sow.

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“…Labor can be induced with intravenous administration of PGF 2a at term [1,2,13] and even before term [3]. During spontaneous as well as oxytocin-induced labor PGE and PGF concentrations in amniotic fluid rise [4,14] and plasma levels of 13,14-dihydro-15-keto-PGF 2 (PGFM) also rise [11] although not until labor is in the active phase [6], The failure to detect a singificant increase in circulating PGFM levels in early labor [6,8] has cast some doubt on the importance of endogenous prostaglandin F generation for the initiation of labor. It is possible, however, that the uterine sensitivity to PGF 2a increases so much towards term that to elicit uterine contractions PGFM levels need not rise above normal levels.…”

Section: Introductionmentioning

confidence: 99%

Plasma prostaglandin F_2αand plasma 13,14-dihydro-15-keto-prostaglandin F_2αlevels in women during induction of labor with i. v. infusion of prostaglandin F_2αin relation to uterine contractions

Rasmussen¹,

Johannesen²,

Allen³

et al. 1985

Journal of Perinatal Medicine

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The concentrations of plasma PGF2 alpha and its main metabolite, 13,14-dihydro-15-keto-PGF2 alpha (PGFM) were measured in serial samples of blood collected in 10 pregnant women at term who were given iv infusions of low doses of PGF2 alpha for induction of labor. Six other women served as controls and were given saline infusions. Uterine contractions began with a mean latency of 62 min in the PGF2 alpha infused women, in controls uterine activity remained unchanged. Plasma PGFM levels had increased significantly 30 min after PGF2 alpha infusion began, rising thereafter in a dose dependent manner. Plasma PGF2 alpha also rose reaching a steady state at 2 hours. No significant changes were observed in the controls. The 6-h infusion resulted in delivery in 5 of the 10 women, in the 5 others the cervical scores increased only by 1.25 points on the average and further treatment was needed to achieve delivery, although prostanoid levels rose to similar levels in all. The data show that when uterine contractions are induced by systemic PGF2 alpha, the levels of PGFM are significantly raised. In spontaneous labor uterine contractions begin long before plasma PGFM rises. Thus, if endogenous PGF2 alpha generation is involved in the initiation of uterine contractions during spontaneous labor, it must be synthetized in the myometrium at quantities too low to raise the levels of circulating PGFM.

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The role of prostaglandin F2α in human parturition

Cited by 138 publications

References 11 publications

Effect of Oxytocics on Prostaglandin Levels in the Third Stage of Labour

Effect of Oxytocics on Prostaglandin Levels in the Third Stage of Labour

Pre-partum changes in the plasma concentrations of progesterone, relaxin, prostaglandin F-2 and 13,14-dihydro-15-keto prostaglandin F-2 in meclofenamic acid-treated sows

Plasma prostaglandin F_2αand plasma 13,14-dihydro-15-keto-prostaglandin F_2αlevels in women during induction of labor with i. v. infusion of prostaglandin F_2αin relation to uterine contractions

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The role of prostaglandin F2α in human parturition

Cited by 138 publications

References 11 publications

Effect of Oxytocics on Prostaglandin Levels in the Third Stage of Labour

Effect of Oxytocics on Prostaglandin Levels in the Third Stage of Labour

Pre-partum changes in the plasma concentrations of progesterone, relaxin, prostaglandin F-2 and 13,14-dihydro-15-keto prostaglandin F-2 in meclofenamic acid-treated sows

Plasma prostaglandin F2αand plasma 13,14-dihydro-15-keto-prostaglandin F2αlevels in women during induction of labor with i. v. infusion of prostaglandin F2αin relation to uterine contractions

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Plasma prostaglandin F_2αand plasma 13,14-dihydro-15-keto-prostaglandin F_2αlevels in women during induction of labor with i. v. infusion of prostaglandin F_2αin relation to uterine contractions