The Role of Proline-Proline-Glutamic Acid (PPE) Proteins in Mycobacterium tuberculosis Virulence: Mechanistic Insights and Therapeutic Implications
Ajibola Ilesanmi,
Oluwasanmi M Odeniran,
Lenora Tatsipie
et al.
Abstract:For decades, tuberculosis (TB), caused by
Mycobacterium tuberculosis
(MTB), has remained a global health challenge. Central to this issue are the proline-proline-glutamic acid (PPE) proteins, which play a pivotal role in the pathogenesis and persistence of MTB. This article explores the molecular mechanisms of PPE proteins and their roles in facilitating MTB’s evasion of the host’s immune system while enhancing virulence and transmission. Focusing on the structural and functional aspects… Show more
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