The Role of Prolactin in Thermoregulation and Water Balance During Heat Stress in Domestic Ruminants

Alamer, Mohammed

doi:10.3923/ajava.2011.1153.1169

Cited by 66 publications

(52 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prolactin levels rise in response to heat stress [46,47] and drop in response to both cold exposure [48] and short photoperiod (winter state) [7]. Importantly, prolactin suppression induces hyperthermia [6]. This is consistent with the observed down-regulation of prolactin secretion in hyperthermic HSF1-/- mice.…”

Section: Discussionsupporting

confidence: 75%

“…Hypothalamic dopamine signalling plays an important role in the regulation of core body temperature [3] and also affects the secretion of prolactin [4,5]. Prolactin modulates heat production and heat loss in the periphery (reviewed by Alamer [6]) and plays an important role in the anticipation of seasonal changes in the environment [7]. Circannual and circadian rhythms in behaviour and physiology, such as core body temperature, are regulated by the hypothalamic suprachiasmatic nucleus (SCN) (reviewed by Korf and von Gall [8]).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Heat Shock Factor 1 Deficiency Affects Systemic Body Temperature Regulation

Ingenwerth¹,

Noichl²,

Stahr³

et al. 2015

Neuroendocrinology

View full text Add to dashboard Cite

Introduction: Heat shock factor 1 (HSF1) is a ubiquitous heat-sensitive transcription factor that mediates heat shock protein transcription in response to cellular stress, such as increased temperature, in order to protect the organism against misfolded proteins. In this study, we analysed the effect of HSF1 deficiency on core body temperature regulation. Materials and Methods: Body temperature, locomotor activity, and food consumption of wild-type mice and HSF1-deficient mice were recorded. Prolactin and thyroid-stimulating hormone levels were measured by ELISA. Gene expression in brown adipose tissue was analysed by quantitative real-time PCR. Hypothalamic HSF1 and its co-localisation with tyrosine hydroxylase was analysed using confocal laser scanning microscopy. Results: HSF1-deficient mice showed an increase in core body temperature (hyperthermia), decreased overall locomotor activity, and decreased levels of prolactin in pituitary and blood plasma reminiscent of cold adaptation. HSF1 could be detected in various hypothalamic regions involved in temperature regulation, suggesting a potential role of HSF1 in hypothalamic thermoregulation. Moreover, HSF1 co-localises with tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, suggesting a potential role of HSF1 in the hypothalamic control of prolactin release. In brown adipose tissue, levels of prolactin receptor and uncoupled protein 1 were increased in HSF1-deficient mice, consistent with an up-regulation of heat production. Conclusion: Our data suggest a role of HSF1 in systemic thermoregulation.

show abstract

Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Heat Shock Factor 1 Deficiency Affects Systemic Body Temperature Regulation

Ingenwerth¹,

Noichl²,

Stahr³

et al. 2015

Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…2010). Similarly, heat-induced increase in circulating prolactin (Alamer 2011) might partially mediate the blunted lipolytic response observed during HS (LaPensee et al. 2006; Brandebourg et al.…”

Section: Discussionmentioning

confidence: 99%

Heat stress increases insulin sensitivity in pigs

et al. 2015

View full text Add to dashboard Cite

Proper insulin homeostasis appears critical for adapting to and surviving a heat load. Further, heat stress (HS) induces phenotypic changes in livestock that suggest an increase in insulin action. The current study objective was to evaluate the effects of HS on whole-body insulin sensitivity. Female pigs (57 ± 4 kg body weight) were subjected to two experimental periods. During period 1, all pigs remained in thermoneutral conditions (TN; 21°C) and were fed ad libitum. During period 2, pigs were exposed to: (i) constant HS conditions (32°C) and fed ad libitum (n = 6), or (ii) TN conditions and pair-fed (PFTN; n = 6) to eliminate the confounding effects of dissimilar feed intake. A hyperinsulinemic euglycemic clamp (HEC) was conducted on d3 of both periods; and skeletal muscle and adipose tissue biopsies were collected prior to and after an insulin tolerance test (ITT) on d5 of period 2. During the HEC, insulin infusion increased circulating insulin and decreased plasma C-peptide and nonesterified fatty acids, similarly between treatments. From period 1 to 2, the rate of glucose infusion in response to the HEC remained similar in HS pigs while it decreased (36%) in PFTN controls. Prior to the ITT, HS increased (41%) skeletal muscle insulin receptor substrate-1 protein abundance, but did not affect protein kinase B or their phosphorylated forms. In adipose tissue, HS did not alter any of the basal or stimulated measured insulin signaling markers. In summary, HS increases whole-body insulin-stimulated glucose uptake.

show abstract

“…We recently reviewed these responses in lactating dairy cattle in depth (Dunshea et al 2013), and thus the responses in lactating cattle will not be covered here. Prolactin modulates sweat gland function (Alamer 2011) and is involved in maintaining electrolyte and water balance in the heat-stressed mammalian gut, kidney and mammary gland (Collier et al 1982;Faichney and Barry 1986). Prolactin increases insulin secretion (Bole-Feysot et al 1998) while also reducing the number of insulin receptors in adipose tissue (McNamara 1991).…”

Section: Insulin Resistance and Heat Tolerancementioning

confidence: 99%

Potential nutritional strategies for the amelioration or prevention of high rigor temperature in cattle – a review

DiGiacomo¹,

Leury²,

Dunshea³

2014

Anim. Prod. Sci.

View full text Add to dashboard Cite

Abstract. Environmental conditions influence animal production from an animal performance perspective and at the carcass level post-slaughter. High rigor temperature occurs when the animal is hyperthermic pre-slaughter, and this leads to tougher meat. Hyperthermia can result from increased environmental temperature, exercise, stress or a combination of these factors. Consumer satisfaction with beef meat is influenced by the visual and sensory traits of the product when raw and cooked, with beef consumers commonly selecting tenderness of the product as the most important quality trait. High rigor temperature leads to a reduction in carcass and eating quality. This review examines some possible metabolic causes of hyperthermia, with focus on the importance of adipose tissue metabolism and the roles of insulin and leptin. Potential strategies for the amelioration or prevention of high rigor temperature are offered, including the use of dietary supplements such as betaine and chromium, anti-diabetic agents such as thiazolidinediones, vitamin D, and magnesium (Mg) to provide stress relief.

show abstract

The Role of Prolactin in Thermoregulation and Water Balance During Heat Stress in Domestic Ruminants

Cited by 66 publications

References 40 publications

Heat Shock Factor 1 Deficiency Affects Systemic Body Temperature Regulation

Heat Shock Factor 1 Deficiency Affects Systemic Body Temperature Regulation

Heat stress increases insulin sensitivity in pigs

Potential nutritional strategies for the amelioration or prevention of high rigor temperature in cattle – a review

Contact Info

Product

Resources

About