The role of progesterone in prevention of preterm birth

Dodd, Jodie M; Crowther, Caroline A

doi:10.2147/ijwh.s4730

Cited by 39 publications

(49 citation statements)

References 124 publications

(156 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, progesterone has recognized anti-inflammatory properties, raising a possible link between inflammatory processes, alterations in progesterone receptor expression and the onset of preterm labor. 11 The objectives of the study were…”

Section: Introductionmentioning

confidence: 99%

Role of oral micronized progesterone versus vaginal progesterone for prevention of preterm labour

Natu

Sonker

Chandwaskar

et al. 2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: Preterm birth remains a significant problem in obstetric care, affecting women and babies world-wide. Progesterone has an essential role in maintaining pregnancy by suppression of the calcium–calmodulin–myosin light chain kinase system. This study reflects the use of progesterone in preventing preterm birth.Methods: The data were collected as a retrospective study from SAMC and PGI Obstetric and Gynaecology Department.Results: With the use of Oral micronized progesterone out of 15 cases, term delivery 9 cases i.e. 60% and preterm delivery 6 cases i.e 40% and, with the use of vaginal progesterone suppository out of 15 cases, term delivery 11 cases i.e.73.3%, preterm delivery only 4 cases i.e 26.7%.Conclusions: Progesterone appears to be safe and efficacious in reducing the risk of preterm birth as well as NICU admissions, and neonatal morbidity and mortality in high risk patients. However, there is limited information available relating to longer-term infant and childhood outcomes, the assessment of which remains a priority. Further, trials are required to assess the optimal timing, mode of administration and dose of administration of progesterone therapy when given to women considered to be at increased risk of early birth.

show abstract

Section: Introductionmentioning

confidence: 99%

Role of oral micronized progesterone versus vaginal progesterone for prevention of preterm labour

Natu

Sonker

Chandwaskar

et al. 2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…Birth at 28-31 weeks is defined as very premature birth, which accounts for less than 1% of all deliveries and about 10% of all preterm births. Birth at 32-33 and 34-36 weeks of gestation are called mild and moderate preterm birth, respectively, which account for the majority (85%) of all preterm births (1)(2)(3)(4)(5)(6)(7)(8)(9). Annually, about 13 million babies are born as premature worldwide.…”

Section: Introductionmentioning

confidence: 99%

“…Also, the financial burden of preterm birth is another important negative consequence. For instance, in an estimation of preterm birth costs in US in 2005, the economic costs related to preterm birth, including costs of caring from the premature infants for health system, educational costs, and the loss of labor force productivity, has been estimated to be more than 26.2 billion dollars (3,12).…”

Section: Introductionmentioning

confidence: 99%

“…So, today, progestins that are available in various forms are the first prescription of clinicians for the women who have the risk factors of preterm delivery. Therefore, in the recent decades, many studies have been done to evaluate the efficacy, side effects, and other aspects of progestins in the management of preterm birth (1,3,7,11,14,18). Although in many cases, the efficacy of these drugs has been approved, but many researchers and clinicians believe that the efficacy of these drugs in the prevention of preterm birth in women with single risk factor is different from that of women with multiple risk factors.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Efficacy of Progesterone Therapy for the Prevention of Preterm Labor in Women with Mixed Risk-factors: A Systematic Review and Meta-analysis of Randomized Clinical Trials

Ara¹,

Bahrami²,

Bahrami³

et al. 2018

Erciyes Med J

View full text Add to dashboard Cite

Background: Preterm birth is a worldwide concern with widespread negative consequences. Therefore, prevention of preterm birth has become a top priority of health managers and clinicians in recent decades.Objective: To evaluate the efficacy of progesterone therapy in the prevention of preterm labor in women with mixed risk factors.Search strategy: An extensive search of electronic databases was done (date last searched April 2016). No restrictions of language, time, or geographic location were applied.Inclusion criteria: All randomized clinical trials of singleton pregnancies with multiple risk factors (including prior preterm birth and short cervical length) that were randomized to treatment with progesterone (intervention group) and placebo or no treatment (control group) were included in meta-analysis.Primary outcome: Our primary outcome was gestational age at delivery.Results: Three Randomized Clinical Trials (521 subjects and 37,823 control women) were included. A random effect model showed that mean gestational age at delivery of progesterone group is 0.18 (-0.41-0.77) month longer than that of control group with with 95% confidence interval but this difference is not statically significant. Conclusions:Progesterone therapy does not have sufficient efficacy in the prevention of preterm labor in women with multiple risk factors. However, further investigation is required to unequivocally establish this result.

show abstract

“…The incidence of preterm labor is reported by the WHO to be 5-11%. 1 Preterm delivery is an international health problem and is responsible for approximately two-thirds of early neonatal morbidity and mortality. 2,3 Yet, current evidence shows that it is possible to reduce the complications caused by prematurity.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Maternal Nifedipine as a Tocolytic Agent on the Doppler Indices of Uterine and Fetal Umbilical and Middle Cerebral Arteries

Abdellateef¹,

Shorbagy²,

Hagras³

et al. 2017

Gynecol Obstet Res Open J

View full text Add to dashboard Cite

CitationAbdellateef SS, El Shorbagy SH, Hagras AM, Ghareeb AE. Assessment of maternal nifedipine as a tocolytic agent on the Doppler indices of uterine and fetal umbilical and middle cerebral arteries. This study was designed to assess the effects of maternal nifedipine administration on blood flow resistance in uterine, umbilical and fetal middle cerebral arteries by evaluating resistance index (RI) and pulsatility index (PI). Patients and Methods: This was a prospective, observational, analytic cohort study performed in 50 pregnant women undergoing nifedipine tocolysis, all women with a singleton pregnancy between 24 and 34 weeks of gestation, each subject acting as her own control. Doppler assessment of uterine, umbilical and fetal middle cerebral (MCA) arteries was performed before and 24 h and 72 h after an initial 20 mg oral dose, which was repeated at 20 min intervals if contractions failed to diminish up to a total maximum dose of 60 mg. The maintenance dose consisted of 20 mg orally every 6 h. We analyzed whether there was a time effect and compared values at the different time-points. Results: The research showed that the UtA-RI has increased significantly after 24 h and after 72 h of nifedipine administration (0 h=0.53; 24 h=0.56; 72 h=0.55; p=0.002, p=0.015 respectively). The MCA-RI had decreased significantly after 24 h (p=0.003) of tocolysis returning to baseline after 72 h (0 h=0.75; 24 h=0.73; 72 h=0.74; p=0.150). The MCA-PI had decreased significantly after 24 h (P=0.024) of tocolysis returning to baseline between 24 h and 72 h (0 h=1.85; 24 h=1.75; 72 h=1.79; p=0.204), with no differences in UtA-PI or in the umbilical arteries Doppler (RI & PI) or in the MCA to umbilical artery ratio. Conclusions: Nifedipine tocolysis is associated with a reduction in RI and PI in the MCA, and an increase in RI in uterine arteries after 24 h but returning to baseline within 72 h, with no long-term effect on fetomaternal circulation in pregnant women at risk of preterm delivery.

show abstract

The role of progesterone in prevention of preterm birth

Cited by 39 publications

References 124 publications

Role of oral micronized progesterone versus vaginal progesterone for prevention of preterm labour

Role of oral micronized progesterone versus vaginal progesterone for prevention of preterm labour

The Efficacy of Progesterone Therapy for the Prevention of Preterm Labor in Women with Mixed Risk-factors: A Systematic Review and Meta-analysis of Randomized Clinical Trials

Assessment of Maternal Nifedipine as a Tocolytic Agent on the Doppler Indices of Uterine and Fetal Umbilical and Middle Cerebral Arteries

Contact Info

Product

Resources

About