The role of production of adipsin and leptin in the development of insulin resistance in patients with abdominal obesity

Vasilenko, M. A.; Kirienkova, E. V.; Skuratovskaia, Daria; Затолокин, Павел; Mironyuk, N. I.; Litvinova, L. S.

doi:10.1134/s160767291704010x

Cited by 43 publications

(43 citation statements)

References 9 publications

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“…Speci cally we showed that adipsin was lower in T2D compared to NGT, which was similar to majority [40,[56][57][58] but not all [10,19] previously published research. In addition, this study showed that 2-hour post-glucose load adipsin was lower in T2D compared to NGT.…”

Section: Discussionsupporting

confidence: 90%

“…Results of these studies support the concept that T2D involves adipocytokines as mediators of low-grade subclinical in ammatory process contributing to pathogenesis of T2D at all stages, i.e. from development to progression, complications, and mortality [7][8][9][19][20][21][22][23]. To date, however, clinical trials have failed to translate these discoveries into T2D treatment [24][25][26].…”

Section: Introductionmentioning

confidence: 55%

“…The 14 measured adipocytokine biomarkers were chosen based on literature review and data including our previous data [39] showing involvement of these biomarkers in T2D development, progression and/or complications [7][8][9][10][11][12][13][14][15][16][19][20][21]. The nal model accounting for the most variance in chronic glycemic control as measured by HbA1c included adipsin and TNF-a.…”

Section: Discussionmentioning

confidence: 99%

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Predictors of HbA1c among adipocytokine biomarkers in African American men with varied glucose tolerance

Barengolts¹,

Akbar

Layden

et al. 2020

Preprint

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Background: Adipocytokines are important in type 2 diabetes (T2D). This study explored adipocytokine associations with acute and chronic hyperglycemia in African American Men (AAM). Methods: Fourteen adipocytokines were measured (multiplex assay) in blood samples from men with normal glucose tolerance (NGT) or T2D (drug-naïve MF(-) or using metformin MF(+)). Acute and chronic hyperglycemia were evaluated at 120-minute of OGTT and by HbA1c, respectively. Results: AAM with T2D (N=21) compared to NGT (N=20) were significantly older (59 vs. 54 years) and had higher body mass index (BMI 35 vs. 27 kg/m2) (p<0.01 for both). Fasting and 120-minute OGTT glucose and insulin were higher in T2D than NGT, however, differences did not reach statistical significance after adjusting for age and BMI. In the fasted state, TNF-a, IL-6, PAI-1 (p<0.01 for all) and IL-13, adiponectin, adipsin, lipocalin (p<0.05 for all) were lower in T2D compared to NGT. At 120-minute post-glucose load (acute hyperglycemia) TNF-a, IL-6, IL-13, IL-8, PAI-1, adiponectin, adipsin (p<0.01 for all) and lipocalin, resistin (p<0.05 for both) were lower in T2D than in NGT group. There were no statistical differences for the other adipocytokines including GM-CSF, IL-7, IL-10, IP-10, and MCP-1. Regression analysis (adjusted for age and BMI) showed that fasting IL-8, TNF-a, adiponectin, lipocalin, resistin, adipsin, and PAI-1 were all associated with HbA1c (p<0.05 for all). Further modeling revealed that after adjusting for age, BMI, glucose tolerance status and metformin use, only adipsin remained significantly associated with HbA1c (p=0.004). The model including adipsin, TNF-a, age, BMI, and group designation (i.e. NGT, MF(-), MF(+)) explained 86% of HbA1c variability. Conclusions: The study suggested that adipsin could be independently associated with HbA1c in AAM with varied glucose tolerance. Additional studies should corroborate these data and provide mechanistic insights for enabling adipsin-related discoveries of novel T2D treatment.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Predictors of HbA1c among adipocytokine biomarkers in African American men with varied glucose tolerance

Barengolts¹,

Akbar

Layden

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Animal studies showed that serum adipsin levels were lower in genetic and acquired mice; however, human studies showed different or even contrary conclusions. Some studies showed that serum adispin levels were higher in obesity, and were positively correlated with BMI and TG. Nevertheless, it has been suggested that in mild‐to‐moderate obese individuals, the circulating adipsin levels are not decreased.…”

Section: Discussionmentioning

confidence: 99%

Relationship between serum adipsin and the first phase of glucose‐stimulated insulin secretion in individuals with different glucose tolerance

Zhou

Ding

et al. 2018

J of Diabetes Invest

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Aims/IntroductionTo detect serum adipsin levels in individuals with different glucose tolerance, and investigate the relationship between adipsisn and the first phase of insulin secretion.Materials and MethodsA total of 56 patients with newly diagnosed type 2 diabetes mellitus, 36 patients with impaired glucose tolerance (IGT) and 45 individuals with normal glucose tolerance were enrolled. Intravenous glucose tolerance tests were carried out to evaluate pancreatic β‐cell function. The serum levels of adipsin, interleukin‐1β and high‐sensitivity C‐reactive protein were assayed.ResultsSerum adipsin levels were significantly lower in the type 2 diabetes mellitus and the IGT patients than those in the normal glucose tolerance group (P < 0.05). The acute insulin response and area under the curve showed a progressive decrease in the normal glucose tolerance and IGT groups, and decreased to the lowest levels in the type 2 diabetes mellitus group (P < 0.05). Adipsin was found to be negatively correlated with waist‐to‐hip ratio, free fatty acid, fasting plasma glucose, 2‐h postprandial plasma glucose, glycated hemoglobin, homeostasis model assessment of insulin resistance, interleukin‐1β and high‐sensitivity C‐reactive protein (P < 0.05 or P < 0.001), and positively correlated with homeostasis model assessment of β‐cell function, high‐density lipoprotein cholesterol, the area under the curve of the first phase insulin secretion and acute insulin response (P < 0.05 or P < 0.001). Stepwise multiple regression analysis showed that homeostasis model assessment for β‐cell function and acute insulin response were independently related to adipsin (P < 0.05).ConclusionsSerum adipsin levels were lower in type 2 diabetes mellitus and IGT patients, and correlated with the first phase of insulin secretion. Adipsin might be involved in the pathology of type 2 diabetes mellitus.

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“…Besides the differential adipose tissue protein composition, we also observe changes at serum levels, related both to obesity and DM. Obesity is known to be associated with a low-grade pro-in ammatory state and many in ammatory adipokines are altered in the secretome of obese patients compared with lean subjects [39,40]. This also happens with the proteins secreted by the adipose tissue, adipokines such Leptin, Adiponectin and Visfatin among others, are dysregulated as a response of fat accumulation [41].…”

Section: Discussionmentioning

confidence: 99%

Untargeted and Targeted Proteomic Analysis of the Impact of Diabetes Mellitus on Two Adipose Tissue Depots and Blood of Obese Patients

Arderiu

Lambert

Padró

et al. 2020

Preprint

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Background: Obesity has increased over the last years and it is one of the most common cardiovascular risk factors. In addition obesity is associated with the development of other metabolic disorders such as insulin resistance and type-2 diabetes mellitus (T2DM). Here, we have investigated two adipose tissue depots (AT) proteome and secreted serum proteins in obese patients to understand fat tissue characteristics in metabolic syndrome and T2DM.Methods: We used an untargeted proteomic approach to compare white AT of subcutaneous (SAT) and visceral (VAT) depots in type 3 obese patients. In silico analysis and bioinformatics were applied to proteomic data to gain systems biology information. By bead-based targeted multiplex assay system, we simultaneously detected and quantified multiple targets in qualified complex samples and analyzed the changes produced in the adipokine serum composition due to obesity and T2DM.Results: Protein composition in SAT and VAT showed significant differences. There was upregulation of proteins related with the endocrine regulation system in SAT, whereas proteins upregulated in VAT were related to metabolic disorders. VAT protein composition was more sensitive to the presence of diabetes than SAT. A pro-inflammatory state, caused by the secretion of cytokines and related adypokines, was observed in the serum protein composition of both obese and diabetic patients.Conclusions: Our results show a synergic alteration in the metabolic and inflammatory state in both VAT and serum due to the presence of diabetes, whereas changes in SAT were related with endocrine regulation.

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The role of production of adipsin and leptin in the development of insulin resistance in patients with abdominal obesity

Cited by 43 publications

References 9 publications

Predictors of HbA1c among adipocytokine biomarkers in African American men with varied glucose tolerance

Predictors of HbA1c among adipocytokine biomarkers in African American men with varied glucose tolerance

Relationship between serum adipsin and the first phase of glucose‐stimulated insulin secretion in individuals with different glucose tolerance

Untargeted and Targeted Proteomic Analysis of the Impact of Diabetes Mellitus on Two Adipose Tissue Depots and Blood of Obese Patients

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