The role of probiotics on slowing down the aging process

Abstract

The gastrointestinal (GI) microbiota is one of the most complex ecosystems in nature that are mainly comprised of bacteria and other microbes like fungi, protozoa, and viruses. More than 1000 bacterial species have been reported in the gut microbiome, of which most of these species belong to Firmicutes (31.1%), Proteobacteria (29.5%), Actinobacteria (25.9%), or Bacteroidetes (7.1%) phylum. A symbiotic relationship, which plays a critical role in host health, exists between intestinal microflora and its host. With aging, the intestinal microbiota profile changes are observed, generally characterized by the decrease in biodiversity, carriage of commensals, and enrichment of opportunistic pathogens. The dysbiosis associated with aging in the gut microbiota increases the risk of several diseases. Probiotics are defined as "live microorganisms that, when administered in adequate amounts, confer a health benefit on the host" and play crucial functions in improving gut health and disease in all age groups, particularly the elderly induvial. This review focuses on the promising effects of probiotics on slowing down the aging process, treating age-related diseases, and improving the quality of life in light of the current clinical studies.

Distribution of Vaginal and Gut Microbiome in Advanced Maternal Age

“…In the present study, we observed a trend toward decreased diversity and richness in the AMA group as indicated by the PD, ACE, and Shannon indices, also suggesting that aging is an important factor affecting microbial composition. Similar to Lee and Sanlibaba's studies (Lee et al, 2022;Sanlibaba et al, 2022), the gut microbiota changes are generally characterized by the decrease in biodiversity and enrichment of opportunistic pathogens with aging. The gestational gut microbiota is characterized by a low alpha diversity index (intraindividual bacterial diversity) and a high beta diversity index (interindividual bacterial diversity) in the third trimester (Wallace et al, 2019;Mesa et al, 2020).…”

Fabrication and Characterization of PVA–WPI Based Nanofiber Mats for Improved Viability of Lactobacillus rhamnosus GG

“…Probiotics are live microbes that confer health advantages to the host when administered in sufficient proportions (10 9 CFU/day). They have recently drawn a lot of attention owing to their potential to enhance the human health and fend off numerous diseases [1]. These helpful bacteria tend to be found in fermented foods and nutritional supplements, as they have been shown to support immune function, improve digestion, and alleviate some gastrointestinal problems.…”