The Role of Probiotics in the Prevention and Treatment of Atopic Dermatitis in Children: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

Nutrition and atopic dermatitis

“…53 On the other hand, an updated meta-analysis shows that probiotics administered solely to infants appeared to produce negative preventive effects (OR 0.88, p = 0.56) while positive preventive effects if administered to both pregnant mothers and their infants (OR 0.71, p = 0.0006) or solely to pregnant mothers (OR 0.54, p = 0.001). 54 The clinical outcomes of probiotics might be influenced by the timing of administration, duration, strains, or dosage. More powerful RCTs using standardized measurements, and studies analyzing the mechanisms underlying the actions of probiotic supplementation on AD during pregnancy and the postpartum period are necessary to assess the long-term effects of probiotics.…”

COVID-19 multidisciplinary working group

“…During the COVID-19 pandemic, up to 10 May 2021, our organisation recruited 5,431 participants into research studies of which 6% (n=333) were recruited to interventional trials including RECOVERY (n=222) and REMAP-CAP (n=15). 2,3 The COG was also able to review, through weekly virtual meetings, the outcomes from various research studies and interim position statements released from the department of health. Various novel therapeutic agents were implemented into updated guidelines Letters to the editor within 7 days of release of the interim position statements with effective transition into standard care within this time period.…”

“…Various novel therapeutic agents were implemented into updated guidelines Letters to the editor within 7 days of release of the interim position statements with effective transition into standard care within this time period. [2][3][4] In order to evaluate the impact of the COG guidelines, we undertook a trust-wide audit of randomly selected COVID-19 patients admitted between 01 May 2020 and 30 Nov 2020. The majority of patients received appropriate therapeutic interventions during the audit time periods: dexamethasone (93%) and remdesivir (84%).…”

“…Particularly, treatments with mixed-strain probiotics have greater prophylactic and curative effects to both lower the risk of atopic dermatitis and reduce symptoms in children. 2 Interestingly, regarding the preventive effect of such probiotics, strong evidence-based proofs recently demonstrated that supplementation with probiotics in both the antenatal period (in pregnant mothers) and postnatal period (in breastfeeding mothers then in infants) was efficient to reduce the incidence of atopic dermatitis in infancy and childhood. 3,4 The era of microbiome-targeting drugs is here, and probiotics ought to be considered as a powerful, adjunct, preventive and curative therapy; especially in the paediatric population.…”

“…Among them were 463 who had MCH amounting to ≤28 pg vs 209 with MCV of ≤80 fL. 2 Accordingly, given the fact that MCH of ≥28 pg is more prevalent than MCV of ≤80 fL in IDWA subjects, a MCH of <28 pg should be a red flag for IDWA, prompting further investigation along the lines proposed by Al-Naseem et al 3 The recognition of IDWA has implications for correction of incident iron deficiency and for identification of its underlying cause. Correction of incident iron deficiency (regardless of Hb level) is a matter of urgency in patients with congestive heart failure (CHF).…”