The role of probiotics and natural bioactive compounds in modulation of the common molecular pathways in pathogenesis of atherosclerosis and cancer

Abstract

Atherosclerosis and cancer are ranked among the most serious health problems in human medicine. Various predictive and etiological factors, biomarkers and molecular pathways of disease development and progression common to atherosclerosis and cancer suggest that the two most common diseases in worldwide dimension are far more closely aligned than previously believed. It is hypothesized that atherosclerosis and cancer are variants of a similar disease process. Shared disease progression in atherosclerosis and cancer is the emergence of similar novel approaches to therapy. On previous knowledge, it may be hypothesized that not only common approaches to therapy but also preventive strategies could be efficacious in both diseases. The results of in vitro and in vivo animal experiments, clinical and epidemiological studies and also the results of our experiments using animal experimental models of atherosclerosis and carcinogenesis indicate that probiotics, prebiotics, plants and their extracts and poly-unsaturated fatty acids could be effectively used in prevention of both atherosclerosis and colorectal cancer and decrease the disease risk. Future research should answer the question whether probiotic microorganisms and natural bioactive substances could effectively influence the molecular mechanisms in pathogenesis of atherosclerosis and cancer.

Do Eating Habits of the Population Living in Roma Settlements Differ from Those of the Majority Population in Slovakia?

“…Dairy products are an important source of protein and certain vitamins and minerals, such as vitamin D, vitamin A and vitamins B-12, B-6 and calcium (36). Use of dairy products, especially fermented products containing probiotics is important since probiotics have both local and general biomedical effects, inhibitory effect against pathogens, optimising effect on digestive processes, immunostimulative effect as well as anti-tumour and cholesterol-reducing activities (37).…”

Peptide separation of commercial fermented milk during refrigerated storage

“…Synbiotics (a combination of probiotics and prebiotics) improve survival of probiotics enhancing their effects in the large bowel (Roberfroid, 2000). Several studies have shown additional benefits of probiotics, such as the increase in immune system response and the release of bioactive compounds (Hempel et al, 2012;Bomba et al, 2012). The release of bioactive peptides from a protein sequence can be produced by enzymatic hydrolysis (Udenigwe & Aluko, 2012;Hartmann & Meisel, 2007), by fermentation processes (Hafeez et al, 2014;Udenigwe & Aluko, 2012;Quirós et al, 2005), or by a combination of both and during gastrointestinal digestion of food (Saito, 2008).…”

Безвідходна біотехнологія отримання симбіотика і метабіотика на основі Вifidobacterium longum – Я 3 та Propionibacterium shermanii – 4

“…Для визначення біосумісності препаратівпробіотиків з автохтонноїю мікробіотою необхідно проводити ряд досліджень для конкретного індивідуума, або розробляти аутопробіотики, що є досить складним процесом. У зв'язку з цим, фахівці покладають великі надії на групу метаболітних про-і синбіотиків, які в порівнянні з клітинною формою більш стабільні при зберіганні, не знижують свою біологічну активність при застосуванні на тлі лікувального курсу антибіотиків, не спричиняють побічних дій на організм людини при гострих запальних процесах і хронічних захворюваннях, на відміну від живих мікроорганізмів (Di Caro et al, 2005;Chang et al, 2009;Bomba et al, 2012;Bourdichon et al, 2012).…”