The Role of Presepsin in Patients with Acute Surgical Diseases

Abstract

AIM: The purpose of this study was to determine the level of significance of markers in the development of intra-abdominal hypertension in patients with acute surgical diseases of the abdominal cavity.
 METHODS: The authors surveyed 100 patients who were monitored at the Regional Clinical Hospital, Karaganda. The criterion for inclusion in the study was the informed consent of patients to participate in the study, the presence of acute surgical pathology, and the monitoring of intra-abdominal pressure over time. The exclusion criteria for patients from the study is the presence of sub and decompensation of associated diseases: trauma (hematoma of the bladder), bladder tumour and impaired integrity of the pelvic ring. The design of the study was by the legislation of the Republic of Kazakhstan, international ethical norms and normative documents of research organizations, approved by the ethics committee of the Karaganda State Medical University.
 RESULTS: According to the world scientific literature, there are 4 indicators that change their value in response to increases in pressure in the abdominal cavity: fibrinogen and prothrombin index (the main indicators of the coagulogram); marker of blood clots D-dimer; early marker of translocation of bacterial flora into the bloodstream sCD14 (presepsin).
 CONCLUSION: The authors concluded that the obtained data indicate that an increase in intra-abdominal pressure in acute surgical diseases of the abdominal cavity causes hypercoagulation and an increase in presepsin. Monitoring IAP with simultaneous measurement of the level of presepsin significantly improves the stratification of critical patients in need of emergency surgery.

The role of ischemia-modified albumin, presepsin, delta neutrophil index, and inflammatory markers in diagnosing acute cholecystitis

“…These studies demonstrated that presepsin was a sensitive and specific predictor for the development of sepsis in abdominal organs, leading the authors to conclude that presepsin could be utilized as a diagnostic marker. [18,19] In this study, the cutoff value for presepsin in patients with acute cholecystitis was found to be 134. Oxidative stress responses, marked by a balance between prooxidants and antioxidants, are crucial aspects of the body's response to surgical stress and the activation of inflammatory cells.…”

Endovascular surgery for the treatment of purulent and necrotic complications in diabetic foot syndrome

“…The main conclusion based on the analysis of the study results is that stenting and balloon angioplasty of the arteries of the lower extremities in cases of purulent and necrotic complications of DFS can reduce the number of repeated minor interventions and foot amputations 3.8 times and the frequency of hip disarticulations 6 times as well as preserve the weightbearing ability of the feet in 94.2% of patients ( 14 , 15 ). Endovascular interventions, stenting, and balloon angioplasty, on 1 of the tibial arteries only show encouraging positive treatment outcomes, and therefore is sufficient in terms of the number of arteries required for the intervention to obtain the expected result.…”

Bacterial translocation in colorectal cancer patients

“…In a clinical study of patients with acute surgical pathology, including acute intestinal obstruction, some correlation has been found between an increase in intraabdominal pressure and an increase in the level of presepsin. Moreover, some researchers found that presepsin can be used to stratify the risk of abdominal sepsis [62].…”