The role of prescription drugs in female overactive bladder syndrome—A population‐wide cohort study

Abstract

Purpose: Overactive bladder (OAB) syndrome has severe effects on quality of life.Certain drugs are known risk factors for OAB but have not been investigated in a population-wide cohort. The objective of this study was to investigate the role of prescription drugs in the etiology of the OAB.Methods: Retrospective cohort study using a population-wide database of 4 185 098 OAB-naïve women followed Strengthening the Reporting of Observational Studies in Epidemiology guidelines. We investigated the subscription use of anticholinergic medication and 188 chemical substances, which are suspected triggers for OAB (trigger medications [TMs]). We hypothesized a relationship between the prescription for one or more TM and the prescription for anticholinergic medication against OAB (marker medication [MM]). Results: The use of MM in Austria increased from 2009 to 2012 on average by 0.025 percentage points per year (95% confidence interval [CI]: 0.015-0.036). In December 2012, 1 in 123 women filled a prescription for any MM, equaling anaverage utilization of 0.84%. The relative risk of filling a prescription for a MM 6 months after filling a prescription for a TM was 2.70 (95% CI: 2.64-2.77). All investigated medication classes showed a higher risk for the prescription for MM. Medication from classes "genitourinary system and sex hormones" and "systemic anti-infectives" caused the highest increase in risk (109% and 89%, respectively).Prescriptions for class "cardiovascular system" caused the lowest increase in the risk (15%).Conclusion: Certain prescription medications are a significant risk factor for the need to take anticholinergic medication as a consequence. K E Y W O R D S drug interactions, drug utilization, overactive bladder, pharmacoepidemiology, polypharmacy 1 | INTRODUCTION Overactive bladder (OAB) syndrome is a form of lower urinary tract dysfunction, characterized by urinary urgency, frequency, and nocturia, with or without urinary incontinence. Epidemiological data estimate 1 the prevalence of the OAB at 17% in Austria, 2 in line with the estimated prevalence of 13%-16% of the female population in international studies. 3 Quality of life is severely reduced in 66% of affected women as shown in a large epidemiologic study from Norway. 4 The most important known risk factors for OAB are increasing age, obesity, presence of pelvic organ prolapse, parity, and the use of certain prescription drugs. 5This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Metabolik Sendrom İlişkili Parametrelerin Aşırı Aktif Mesane Üzerine Etkisi

“…The etiology of OAB has been shown to be associated with age, obesity, DM, cardiac disorders, pelvic organ prolapse, parity and drug use. (6,13,(22)(23)(24) In this study, the OAB-V8 score was compared with age, weight, height, BMI, hip circumference, waist circum- 13) In this study, the OAB-V8 score was observed to increase with age. The mean OAB-V8 score below 45 years was 6.33, while above 45 years it was 9.51 and there was a significant difference (p<0.005).…”

“…Studies have shown that demographic features like age, obesity and parity (6) and laboratory parameters like diabetes mellitus (DM) and hyperlipidemia (7)(8) are associated with OAB. A strong relation was detected especially between obesity and OAB(9,10) but there is no study on obesity type in literature.…”

“…(6,13,14,22) Palma et al showed the OAB prevalence increased especially at 40-50 years. (22) Liu et al reported women over 50 years of age had OAB rates 2.4 times higher.…”