Abstract:Objectives: In children, acute liver failure (ALF) is a severe condition with high mortality. As some patients need liver transplantation (LT), it is essential to predict the fatal evolution and to refer them early for LT if needed. Our study aimed to evaluate the prognostic criteria and scores for assessing the outcome in children with ALF. Methods: Data of 161 children with ALF (54.66% female, mean age 7.66 ± 6.18 years) were analyzed based on final evolution (32.91% with fatal evolution or LT) and etiology.… Show more
“…Some cases have tested positive for human adenoviruses and/or SARS-CoV-2 infection. Pediatric ALF differs from adult ALF, according to the type, the diversity of causes and the late appearance of hepatic encephalopathy [ 19 ]. In pediatric ALF, 20% of those who never developed hepatic encephalopathy died or underwent liver transplantation.…”
mentioning
confidence: 99%
“…In pediatric ALF, 20% of those who never developed hepatic encephalopathy died or underwent liver transplantation. Currently, 10–15% of liver transplantation indications in children are in ALF patients [ 19 ]. Finding the best-predicting score in pediatric ALF and early referral of the children to a specialized center are the most important issues ( Figure 1 ) [ 19 ].…”
Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF), respectively, occur in patients with normal liver and patients with chronic liver diseases, including cirrhosis [...]
“…Some cases have tested positive for human adenoviruses and/or SARS-CoV-2 infection. Pediatric ALF differs from adult ALF, according to the type, the diversity of causes and the late appearance of hepatic encephalopathy [ 19 ]. In pediatric ALF, 20% of those who never developed hepatic encephalopathy died or underwent liver transplantation.…”
mentioning
confidence: 99%
“…In pediatric ALF, 20% of those who never developed hepatic encephalopathy died or underwent liver transplantation. Currently, 10–15% of liver transplantation indications in children are in ALF patients [ 19 ]. Finding the best-predicting score in pediatric ALF and early referral of the children to a specialized center are the most important issues ( Figure 1 ) [ 19 ].…”
Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF), respectively, occur in patients with normal liver and patients with chronic liver diseases, including cirrhosis [...]
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