The role of precision medicine in bronchiectasis: emerging data and clinical implications

The Precision Medicine Era of Bronchiectasis

“…An extension of clinical phenotyping includes radiological pattern (i.e., cylindrical, varicose, or cystic); underlying etiology, including immunodeficiency subtypes; and disease overlap with asthma, COPD or allergic bronchopulmonary aspergillosis (ABPA), and primary ciliary dyskinesia (PCD)–related bronchiectasis ( 6 – 8 ). Clinical phenotyping in isolation, however, represents only part of a larger clinical picture, one that must account for disease severity, activity, and impact, which vary widely among phenotypes ( 46 , 47 ). Molecular endotyping, assessing disease through underlying pathobiological mechanisms and/or treatment response, should be combined with phenotyping for a holistic view.…”