The role of PRDMs in cancer: one family, two sides

Mzoughi, Slim; Tan, Ying Xim; Low, Diana; Guccione, Ernesto

doi:10.1016/j.gde.2016.03.009

Cited by 80 publications

(97 citation statements)

References 73 publications

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“…However, enzymatic activity has been demonstrated for only some members (see Table 1) and functional data is still lacking for many of these proteins. Nevertheless, most PRDM family members have been associated with dysregulation in multiple cancer types (reviewed in (Mzoughi et al., 2016)).…”

Section: Introductionmentioning

confidence: 99%

“…Structurally, HMTs can be broadly categorized into three functional enzymatic families, the SET (Suppressor of variegation, Enhancer of zeste, Trithorax)-domain-containing methyltransferases, the non-SET DOT1-like (DOT1L) lysine methyltransferases, the PRDM family, containing a PR (PRDI-BF1-RIZ1 homologous) domain that is structurally and functionally similar to the SET domain, and the PRMT1 family which shares a common methyltransferase domain (Katoh, 2016;Mzoughi et al, 2016;Nguyen and Zhang, 2011;Schotta et al, 2004;Teyssier et al, 2010). In most cases, there is little redundancy between family members, owing to their methyl group-and cell type-specificity.…”

Section: Introductionmentioning

confidence: 99%

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Dysregulation of histone methyltransferases in breast cancer – Opportunities for new targeted therapies?

Michalak

Visvader

2016

Molecular Oncology

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Histone methyltransferases (HMTs) catalyze the methylation of lysine and arginine residues on histone tails and non-histone targets. These important post-translational modifications are exquisitely regulated and affect chromatin compaction and transcriptional programs leading to diverse biological outcomes. There is accumulating evidence that genetic alterations of several HMTs impinge on oncogenic or tumor-suppressor functions and influence both cancer initiation and progression. HMTs therefore represent an opportunity for therapeutic targeting in those patients with tumors in which HMTs are dysregulated, to reverse the histone marks and transcriptional programs associated with aggressive tumor behavior. In this review, we describe the known histone methyltransferases and their emerging roles in breast cancer tumorigenesis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dysregulation of histone methyltransferases in breast cancer – Opportunities for new targeted therapies?

Michalak

Visvader

2016

Molecular Oncology

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“…The PRDI‐BF1 and RIZ homology domain (PRDM) family of proteins have been reported to be involved in pathological conditions, particularly in cancer . PRDM1 is silenced in human diffuse large B cell lymphoma .…”

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confidence: 99%

PRDM8 exhibits antitumor activities toward hepatocellular carcinoma by targeting NAP1L1

Chen

Gao

et al. 2018

Hepatology

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“…These two alternative products are involved in tumorigenesis with an unusual yin-yang manner. A large number of human cancers, including breast, liver, bone, lung, colon, neuroendocrine cancers and melanoma are characterized by the loss or the decreased expression of the PR+ form and a normal or upregulated expression of PR− form [24,25,26,27,28,29,30,31]. RIZ gene deletion occurs also in colon, breast and liver cancers [5,32,33].…”

Section: Introductionmentioning

confidence: 99%

Critical Function of PRDM2 in the Neoplastic Growth of Testicular Germ Cell Tumors

Zazzo

Porcile

Bartollino

et al. 2016

Biology

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Testicular germ cell tumors (TGCTs) derive from primordial germ cells. Their maturation is blocked at different stages, reflecting histological tumor subtypes. A common genetic alteration in TGCT is a deletion of the chromosome 1 short arm, where the PRDM2 gene, belonging to the Positive Regulatory domain gene (PRDM) family, is located. Expression of PRDM2 gene is shifted in different human tumors, where the expression of the two principal protein forms coded by PRDM2 gene, RIZ1 and RIZ2, is frequently unbalanced. Therefore, PRDM2 is actually considered a candidate tumor suppressor gene in different types of cancer. Although recent studies have demonstrated that PRDM gene family members have a pivotal role during the early stages of testicular development, no information are actually available on the involvement of these genes in TGCTs. In this article we show by qRT-PCR analysis that PRDM2 expression level is modulated by proliferation and differentiation agents such as estradiol, whose exposure during fetal life is probably an important risk factor for TGCTs development in adulthood. Furthermore in normal and cancer germ cell lines, PRDM2 binds estradiol receptor α (ERα) and influences proliferation, survival and apoptosis, as previously reported using MCF-7 breast cancer cell line, suggesting a potential tumor-suppressor role in TGCT formation.

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The role of PRDMs in cancer: one family, two sides

Cited by 80 publications

References 73 publications

Dysregulation of histone methyltransferases in breast cancer – Opportunities for new targeted therapies?

Dysregulation of histone methyltransferases in breast cancer – Opportunities for new targeted therapies?

PRDM8 exhibits antitumor activities toward hepatocellular carcinoma by targeting NAP1L1

Critical Function of PRDM2 in the Neoplastic Growth of Testicular Germ Cell Tumors

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