The role of polyunsaturated fatty acids in neuronal signaling in depression and cognitive processes

Stachowicz, Katarzyna

doi:10.1016/j.abb.2023.109555

Cited by 12 publications

(8 citation statements)

References 43 publications

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“…In addition, reactive oxygen species and inflammatory cytokines that could be induced by unreasonable intake of PUFAs have the importance in the progression of depression ( 67 ). Previous studies have shown that some n-6 PUFAs are able to activate inflammatory responses and lead to the accumulation of reactive oxygen species and pro-inflammatory factors ( 68 , 69 ). These alterations might affect the integrity of the cell membrane, leading to alteration of intestinal flora, systemic inflammation and abnormal neurotransmitter transport in the brain ( 6 , 70 ).…”

Section: Discussionmentioning

confidence: 99%

Association between plasma polyunsaturated fatty acids and depressive among US adults

Wang,

Yan,

et al. 2024

Front. Nutr.

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BackgroundDepression is associated with greater functional impairment and high societal costs than many other mental disorders. Research on the association between plasma polyunsaturated fatty acids (PUFAs) levels and depression have yielded inconsistent results.ObjectiveTo evaluate whether plasma n-3 and n-6 PUFAs levels are associated with depression in American adults.MethodsA cross-sectional study included 2053 adults (aged ≥20 y) in the National Health and Nutrition Examination Survey (NHANES), 2011–2012. The level of plasma n-3 and n-6 PUFAs were obtained for analysis. Self-reported Patient Health Questionnaire-9 (PHQ-9) was used to identify the depression status. Binary logistic regression analysis was performed to evaluate the association between quartiles of plasma n-3 and n-6 PUFAs and depression after adjustments for confounders.ResultsThe study of 2053 respondents over 20 years of age with a weighted depression prevalence of 7.29% comprised 1,043 men (weighted proportion, 49.13%) and 1,010 women (weighted, 50.87%), with a weighted mean (SE) age of 47.58 (0.67) years. Significantly increased risks of depression over non-depression were observed in the third quartiles (OR = 1.65, 95% CI = 1.05–2.62) for arachidonic acid (AA; 20:4n-6); the third quartiles (OR = 2.20, 95% CI = 1.20–4.05) for docosatetraenoic acid (DTA; 22:4n-6); the third (OR = 2.33, 95% CI = 1.34–4.07), and highest quartiles (OR = 1.83, 95% CI = 1.03–3.26) for docosapentaenoic acid (DPAn-6; 22:5n-6); and the third (OR = 2.18, 95% CI = 1.18–4.03) and highest quartiles (OR = 2.47, 95% CI = 1.31–4.68) for docosapentaenoic acid (DPAn-3; 22:5n-3); the second (OR = 2.13, 95% CI = 1.24–3.66), third (OR = 2.40, 95% CI = 1.28–4.50), and highest quartiles (OR = 2.24, 95% CI = 1.08–4.69) for AA/docosahexaenoic acid (DHA; 22:6n-3) ratio compared with the lowest quartile after adjusting for confounding factors.ConclusionHigher plasma levels of AA, DTA, DPAn-6, DPAn-3 PUFAs, and AA/DHA ratio may be potential risk factors for depression in US adults.

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Section: Discussionmentioning

confidence: 99%

Association between plasma polyunsaturated fatty acids and depressive among US adults

Wang,

Yan,

et al. 2024

Front. Nutr.

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“…In addition to AA (20:4), the parent fatty acid of AEA and 2-AG, this family includes other fatty acids such as ɑ-linolenic acid (ALA; 18:3), EPA (20:5), DHA (22:6), linoleic acid (LA; 18:2), DA (22:4), and others. Dysregulation of PUFA homeostasis was found to worsen the course of mental illness and is associated with neurodegenerative processes ( Petermann et al, 2022 ; Stachowicz, 2023 ). In a recent review of meta-analyses, PUFA supplementation was found to be partially favorable in treatment of anxiety, depression, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), dementia, mild cognitive impairment, Huntington’s disease, and schizophrenia ( Gao et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Endocannabinoid basis of personality—Insights from animal model of social behavior

Kogan,

Begmatova,

Vinnikova

et al. 2023

Front. Pharmacol.

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Rationale: The endocannabinoid system is known to be involved in learning, memory, emotional processing and regulation of personality patterns. Here we assessed the endocannabinoid profile in the brains of mice with strong characteristics of social dominance and submissiveness.Methods: A lipidomics approach was employed to assess the endocannabinoidome in the brains of Dominant (Dom) and Submissive (Sub) mice. The endocannabinoid showing the greatest difference in concentration in the brain between the groups, docosatetraenoyl ethanolamine (DEA), was synthesized, and its effects on the physiological and behavioral responses of Dom and Sub mice were evaluated. mRNA expression of the endocannabinoid receptors and enzymes involved in PUFA biosynthesis was assessed using qRT-PCR.Results: Targeted LC/MS analysis revealed that long-chain polyunsaturated ethanolamides including arachidonoyl ethanolamide (AEA), DEA, docosatrienoyl ethanolamide (DTEA), eicosatrienoyl ethanolamide (ETEA), eicosapentaenoyl ethanolamide (EPEA) and docosahexaenoyl ethanolamide (DHEA) were higher in the Sub compared with the Dom mice. Untargeted LC/MS analysis showed that the parent fatty acids, docosatetraenoic (DA) and eicosapentaenoic (EPA), were higher in Sub vs. Dom. Gene expression analysis revealed increased mRNA expression of genes encoding the desaturase FADS2 and the elongase ELOVL5 in Sub mice compared with Dom mice. Acute DEA administration at the dose of 15 mg/kg produced antinociceptive and locomotion-inducing effects in Sub mice, but not in Dom mice. Subchronic treatment with DEA at the dose of 5 mg/kg augmented dominant behavior in wild-type ICR and Dom mice but not in Sub mice.Conclusion: This study suggests that the endocannabinoid system may play a role in the regulation of dominance and submissiveness, functional elements of social behavior and personality. While currently we have only scratched the surface, understanding the role of the endocannabinoid system in personality may help in revealing the mechanisms underlying the etiopathology of psychiatric disorders.

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“…It results from the shear force, a component of the force vector parallel to the material cross section. Membrane fluidity refers to the viscosity of the lipid layer of a cell membrane or synthetic lipid membrane [ 7 ]. Young’s modulus (E, tensile or compressive modulus), is a mechanical property that measures the tensile or compressive stiffness of a solid material when a force is applied longitudinally.…”

Section: Adhesion As a Physicochemical Phenomenonmentioning

confidence: 99%

“…Physical properties, including external forces, topography, and elastic properties affect cell adhesion and migration [ 5 ]. E.g., by changing membrane elasticity through ATP-driven activity, decomposition of the F-actin network, remodeling of the acto-myosin cytoskeleton, or acidosis-they can change the rate of adhesion binding, strength or become mobile, forming protrusions affecting cell behavior [ 7 , 9 ]. The above parameters can be precisely measured, through techniques described in the last paragraph of the review.…”

Section: Adhesion As a Physicochemical Phenomenonmentioning

confidence: 99%

Physicochemical Principles of Adhesion Mechanisms in the Brain

Stachowicz

2023

IJMS

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The brain functions through neuronal circuits and networks that are synaptically connected. This type of connection can exist due to physical forces that interact to stabilize local contacts in the brain. Adhesion is a fundamental physical phenomenon that allows different layers, phases, and tissues to connect. Similarly, synaptic connections are stabilized by specialized adhesion proteins. This review discusses the basic physical and chemical properties of adhesion. Cell adhesion molecules (CAMs) such as cadherins, integrins, selectins, and immunoglobulin family of cell adhesion molecules (IgSF) will be discussed, and their role in physiological and pathological brain function. Finally, the role of CAMs at the synapse will be described. In addition, methods for studying adhesion in the brain will be presented.

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The role of polyunsaturated fatty acids in neuronal signaling in depression and cognitive processes

Cited by 12 publications

References 43 publications

Association between plasma polyunsaturated fatty acids and depressive among US adults

Association between plasma polyunsaturated fatty acids and depressive among US adults

Endocannabinoid basis of personality—Insights from animal model of social behavior

Physicochemical Principles of Adhesion Mechanisms in the Brain

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