The role of polysaccharide peptide of Ganoderma lucidum as a potent protective vascular endothelial cell, anti inflammation, and antioxidant in STEMI and NSTEMI patients

Sargowo, Djanggan; Aissy, Chamelia Rohadatul; Kalsum, Umi; Nugroho, Faris Wahyu; Kamila, Putri Annisa; Irawan, Dedy; Sitio, Monika; Adrian, Liemena Harold; Pratama, Aditya Reza; Arifin, Yusuf; Fadlan, Rizki; Sari, Diah Ivana; Purwanto, Evita Febriyanti; Rahmah, Firyal Nadiah; Sukatman, Merkuri Puspasari; Rahmawati, Nurul Aini; Fahmiy, Rakhmawati

doi:10.1063/1.5109979

Cited by 3 publications

(1 citation statement)

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“…In a clinical trial involving 45 ST-elevation myocardial infarction (STEMI) and non-STEMI patients, the polysaccharides of G. lucidum (750 mg/day in 3 divided doses for 90 days) decreased the levels of IL-1 and TNF-α, as well as the MDA levels (Sargowo et al. 2019 ). In a recent randomised closed-label clinical trial involving 38 patients with atrial fibrillation, consumption of polysaccharides of G. lucidum (PT Sahabat Lingkungan Hidup, Surabaya, Indonesia), 3 times a day for 90 days, reduced significantly the systolic and diastolic blood pressure, heart rate, LDL-C, IL-1β, IL-6, hsCRP, and TNF-α, compared to placebo-treated patients (Rizal et al.…”

Section: Health Benefits Of G Lucidummentioning

confidence: 99%

The beneficial effects of Ganoderma lucidum on cardiovascular and metabolic disease risk

Chan

Tomlinson

Chan

2021

Pharmaceutical Biology

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Context Various herbal medicines are thought to be useful in the management of cardiometabolic disease and its risk factors. Ganoderma lucidum (Curtis) P. Karst. (Ganodermataceae), also known as Lingzhi, has received considerable attention for various indications, including some related to the prevention and treatment of cardiovascular and metabolic disease by ameliorating major cardiovascular risk factors. Objective This review focuses on the major studies of the whole plant, plant extract, and specific active compounds isolated from G. lucidum in relation to the main risk factors for cardiometabolic disease. Methods References from major databases including PubMed, Web of Science, and Google Scholar were compiled. The search terms used were Ganoderma lucidum , Lingzhi, Reishi, cardiovascular, hypoglycaemic, diabetes, dyslipidaemia, antihypertensive, and anti-inflammatory. Results A number of in vitro studies and in vivo animal models have found that G. lucidum possesses antioxidative, antihypertensive, hypoglycaemic, lipid-lowering, and anti-inflammatory properties, but the health benefits in clinical trials are inconsistent. Among these potential health benefits, the most compelling evidence thus far is its hypoglycaemic effects in patients with type 2 diabetes or hyperglycaemia. Conclusions The inconsistent evidence about the potential health benefits of G. lucidum is possibly because of the use of different Ganoderma formulations and different study populations. Further large controlled clinical studies are therefore needed to clarify the potential benefits of G. lucidum preparations standardised by known active components in the prevention and treatment of cardiometabolic disease.

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Section: Health Benefits Of G Lucidummentioning

confidence: 99%