“…ERAP1 is highly polymorphic, with variants that alter the peptide trimming activity, specificity, and expression, even if they reside far from the active site region. Several ERAP1 genetic variants have been associated with multiple human leukocyte antigen (HLA) class I autoinflammatory disorders, including ankylosing spondylitis (AS), BD, psoriasis, multiple sclerosis (MS), and type I diabetes, as well as essential hypertension and susceptibility to infectious disease, such as human papilloma virus (HPV)-induced cancer, HIV, hepatitis C virus (HCV), and HCMV infection [55][56][57]. In the context of autoimmune diseases, these genetic changes contribute to immune dysregulation in individuals with a specific HLA class I background [57].…”