The Role of Polymethylmethacrylate Antibiotic–loaded Cement in Addition to Debridement for the Treatment of Soft Tissue and Osseous Infections of the Foot and Ankle

Bone tissue regeneration: biology, strategies and interface studies

“…The infected fractures need management including medical debridement, antibiotics, and skeletal stabilization. Frequently, antibiotic-contained cement made of polymethylmethacrylate (PMMA) is implanted to harmonize the antibacterial activity (Schade and Roukis 2010). The growth and differentiation of osteoblasts and osteoclasts are controlled by growth factors, cytokines produced in the bone-marrow ECM, and adhesion structures that facilitate cell-cell and cell-ECM communications (Lu et al 2012).…”

Thermal and Structural Analyses of PMMA/TiO<sub>2</sub> Nanoparticles Composites

“…In addition, PMMA is one of the best organic optical materials which is very suitable for numerous imaging and non-imaging microelectronic applications, including as a photoresistance for direct-write e-beams, X-rays and deep UV microlithographic process and has been widely used to make a variety of optical devices, such as optical lenses either in the pure or doped state [11] [12]. PMMA has been used in skeletal surgery for more than 40 years as a means of securing prosthetic implants and more recently is used as a delivery agent for local high-dose antibiotics to treat soft tissue and osseous infections [13] and it has been extremely utilized for antibiotic delivery system purposes for the treatment of osteomyelitis [14]. Also, PMMA is a widely used support medium for the embedding of intact, undecalcified bone [15].…”

Peroneal Tendon Reconstruction and Coverage for Treatment of Septic Peroneal Tenosynovitis: A Devastating Complication of Lateral Ankle Ligament Reconstruction With a Tendon Allograft

“…Using these guidelines, the present patient would have been in group II, for which open debridement is recommended (17). Polymethylmethacrylate cement beads were used in the present patient, because they have been shown to be an effective adjuvant therapy to aggressive irrigation and debridement in soft tissue infections of the foot and ankle (31). Despite this treatment, both peroneal tendons desiccated and required resection.…”